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Long-term efficacy of olmesartan medoxomil in Chinese hypertensive patients as assessed by clinic, ambulatory and home blood pressure measurements

, : Long-term efficacy of olmesartan medoxomil in Chinese hypertensive patients as assessed by clinic, ambulatory and home blood pressure measurements. Clinical Drug Investigation 32(11): 729-734

There is limited information on the long-term efficacy and safety of olmesartan medoxomil in the management of hypertension in Chinese patients. We therefore conducted the present multicentre, single-arm, prospective, observational study to investigate the 24-week efficacy and safety of olmesartan medoxomil in patients with mild to moderate hypertension. Eligible patients (diastolic blood pressure [BP] 90 109 mmHg and systolic BP <180 mmHg off antihypertensive medication) were started on olmesartan medoxomil 20 mg once daily, with the possible up-titration to 40 mg once daily during 24 weeks of follow-up, to control clinic BP to the target level (<140/90 and <130/80 mmHg in diabetes mellitus). In a subset of enrolled patients, 24-h ambulatory and home BP monitoring were also performed.In the intent-to-treat analysis (n = 348), at 24 weeks of follow-up, the mean SD changes from baseline in clinic systolic/diastolic BP were 21.2 14.2/16.0 8.8 mmHg (p < 0.001). The proportions of patients who achieved the goal BP for systolic, diastolic and both were 81, 80 and 75 %, respectively. Olmesartan medoxomil also significantly (p < 0.001) reduced systolic/diastolic BP measured at patients homes by 17.7 13.1/12.1 7.9 mmHg from baseline (n = 109), and reduced mean 24-h, daytime and night-time ambulatory BP by 13.3 16.3/7.6 9.5 mmHg, 13.9 17.4/8.0 10.4 mmHg and 12.3 18.1/6.8 10.2 mmHg, respectively (n = 87). Seven (2.0 %) serious adverse events were reported during follow-up.In Chinese hypertensive patients, olmesartan medoxomil is efficacious in lowering BP as assessed by three different BP-measuring methods and has an acceptable long-term safety and tolerability profile.


PMID: 23018282

DOI: 10.1007/s40261-012-0003-7

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