+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Does expanded criteria donor status modify the outcomes of kidney transplantation from donors after cardiac death?

, : Does expanded criteria donor status modify the outcomes of kidney transplantation from donors after cardiac death?. American Journal of Transplantation 13(2): 329-336

The outcomes of kidney transplants that simultaneously exhibit donation after cardiac death (DCD) and expanded criteria donor (ECD) characteristics have not been well studied. We examined the outcomes of DCD versus non-DCD kidney transplants as a function of ECD status and the kidney donor risk index (KDRI). A cohort study of 67 816 deceased donor kidney transplant recipients (KTR), including 562 ECD/DCD KTR, from January 1, 2000 to December 31, 2009 was conducted using the Scientific Registry of Transplant Recipients. In a multivariable Cox proportional hazards model, the modestly increased risk of total graft failure in DCD versus non-DCD KTR was not significantly modified by ECD status (hazard ratio1.07 [95% CI: 1.01, 1.15] for non-ECD vs. 1.21 [95% CI: 1.04, 1.40] for ECD, p for interaction = 0.14).Moreover, the hazard ratios did not significantly vary by KDRI quintiles (p = 0.40). Similar trends were seen for death-censored graft failure and death with graft function. In conclusion, ECD status or higher KDRI score did not appreciably increase the relative hazard of adverse graft and patient outcomes in DCD KTR. These findings suggest that the judicious use of ECD/DCD donor kidneys may be an appropriate strategy to expand the donor pool.


PMID: 23136921

DOI: 10.1111/j.1600-6143.2012.04311.x

Other references

Jedrychowski, W., 1978: Prospective study of ventilatory efficiency of the lungs depending on the symptoms of chronic bronchitis. Wiadomosci Lekarskie 31(15): 1029-1035

Pendleton, G., 2001: Immigration. Canada joins U.S. in limiting admission of people with AIDS. Aids Policy & Law 16(13): 3-3

Ngan Kee, W.D.; Khaw, K.S.; Ma, M.L., 1999: The effect of the addition of adrenaline to pethidine for patient-controlled epidural analgesia after caesarean section. We have investigated the addition of adrenaline to pethidine for patient-controlled epidural analgesia after elective Caesarean section. In a randomised, double-blind study, patients received patient-controlled epidural analgesia for 24 h using pe...

Zatelli, S.; Cerino, M.; Fargion, S.; Sampietro, M.; Fiorelli, G.; Cappellini, M.D., 1999: Histological and hepatitis C virological features in politransfused thalassaemia patients. European Journal of Clinical Investigation 29(SUPPL 1): 67, April

Wang, Y.; Zhao, H.; Zhou, Z.; Tian, C.; Xiao, H-Li.; Wang, B-En., 2017: Establishment and Application of Early Risk Stratification Method for Acute Abdominal Pain in Adults. Acute abdominal pain is a common symptom of emergency patients. The severity was always evaluated based on physicians' clinical experience. The aim of this study was to establish an early risk stratification method (ERSM) for addressing adult...

Hirayama Jiro; Ichikawa Kenichi, 1967: Towada pumice flow of the Heian period (761-858 A.D.). Chishitsugaku Zasshi = Journal of the Geological Society of Japan 73(2): 94

Kloc, W.; Imieliński, B.L., 1994: Lateral extra-canalicular lumbar disc herniation. A case of 60 years old female with far-lateral disc herniation within lumbar spine is presented. The herniated disc has been excised from the lateral muscle splitting approach with the use of microscope.

Byard, R.W.; Haas, E.; Marshall, D.T.; Gilbert, J.D.; Krous, H.F., 2009: Characteristic features of pediatric firearm fatalities--comparisons between Australia and the United States. Gunshot deaths in children less than 17 years of age from Adelaide, SA, Australia (1969-2005) and from San Diego County, CA, United States (1988-2005) were compared. Forty-two pediatric gunshot fatalities occurred in South Australia (1.1 cases/yea...

Grim, P.F.; Pope, S.K.; Karlson, K.H.; Taylor, B.J., 1994: The effect of on-site extracorporeal membrane oxygenation on the therapy choice and outcomes of neonates with persistent pulmonary hypertension. The effect of on-site extracorporeal membrane oxygenation (OS-ECMO) and selection criteria on the utilization rate of this technology is unknown. We retrospectively studied 55 neonates who were admitted to Arkansas Children's Hospital from 19...

Chiller, J.M.; Habicht, G.S.; Weigle, W.O., 1971: Kinetic differences in unresponsiveness of thymus and bone marrow cells. Both thymus and bone marrow cells of adult mice can be made specifically unresponsive to human gamma globulin, but each cell population displays a distinct kinetic pattern for both the induction and spontaneous loss of the unresponsive state. Thes...