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Hypoxia induces myocardial regeneration in zebrafish


, : Hypoxia induces myocardial regeneration in zebrafish. Circulation 126(25): 3017-3027

Hypoxia plays an important role in many biological/pathological processes. In particular, hypoxia is associated with cardiac ischemia. which, although initially inducing a protective response, will ultimately lead to the death of cardiomyocytes and loss of tissue, severely affecting cardiac functionality. Although myocardial damage/loss remains an insurmountable problem for adult mammals, the same is not true for adult zebrafish, which are able to completely regenerate their heart after extensive injury. Myocardial regeneration in zebrafish involves the dedifferentiation and proliferation of cardiomyocytes to replace the damaged/missing tissue; at present, however, little is known about what factors regulate this process. and Results-We surmised that ventricular amputation would lead to hypoxia induction in the myocardium of zebrafish and that this may play a role in regulating the regeneration of the missing cardiac tissue. Using a combination of O2 perturbation, conditional transgenics, in vitro cell culture, and microarray analysis, we found that hypoxia induces cardiomyocytes to dedifferentiate and proliferate during heart regeneration in zebrafish and have identified a number of genes that could play a role in this process. -These results indicate that hypoxia plays a positive role during heart regeneration, which should be taken into account in future strategies aimed at inducing heart regeneration in humans.

US$19.90

PMID: 23151342

DOI: 10.1161/CIRCULATIONAHA.112.107888


Other references

Ling, H.; Luo, E.; Dai, W., 2006: A numerical simulation method and analysis of a complete thermoacoustic-Stirling engine. Thermoacoustic prime movers can generate pressure oscillation without any moving parts on self-excited thermoacoustic effect. The details of the numerical simulation methodology for thermoacoustic engines are presented in the paper. First, a four-...

Nakahata, K.; Uehara, S.; Nishikawa, S.; Kawatsu, M.; Zenitani, M.; Oue, T.; Okuyama, H., 2016: Aldehyde Dehydrogenase 1 (ALDH1) Is a Potential Marker for Cancer Stem Cells in Embryonal Rhabdomyosarcoma. Cancer stem cells (CSCs) are defined as a small population of cancer cells with the properties of high self-renewal, differentiation, and tumor-initiating functions. Recent studies have demonstrated that aldehyde dehydrogenase 1 (ALDH1) is a marke...

Maachi, K.; Berthoux, P.; Burgard, G.; Alamartine, E.; Berthoux, F., 1995: Results of a 1-year randomized controlled trial with omega-3 fatty acid fish oil in renal transplantation under triple immunosuppressive therapy. Transplantation Proceedings 27(1): 846-849

Anonymous, 1957: The Future of the National Medical Association. Journal of the National Medical Association 49(6): 411-425

Booth, C.C., 2000: Changing concepts of health and disease during the 20th century. Sir Christopher Booth looks at the major medical achievements of the 20th century, from the discovery of vitamins to the eradication of smallpox, and asks where scientific development might lead physicians in the new millennium.

Wattrang, E.; Almqvist, M.; Johansson, A.; Fossum, C.; Wallgren, P.; Pielberg, G.; Andersson, L.; Edfors-Lilja, I., 2005: Confirmation of QTL on porcine chromosomes 1 and 8 influencing leukocyte numbers, haematological parameters and leukocyte function. A genome wide search in European Wild Boar x Swedish Yorkshire (W x Y) inter-cross pigs has earlier identified quantitative trait loci (QTL) for leucocyte number and function on porcine chromosomes 1 and 8 (SSC1 and 8). To verify the involvement o...

Salvigni, G.; Barozzi, G.S., 1979: Experimental tests on a tractor cab working in pesticide-polluted atmospheres. A series of tests was carried out on a tractor cab specially developed to protect the driver from chemicals. The system is based on pressurising the cabs and uses activated carbon adsorption air filters. Results show that even after a period of op...

Kraft, R.O.; Fry, W.J.; Wilhelm, K.G.; Ransom, H.K., 1967: Selective gastric vagotomy. A critical reappraisal. Archives of Surgery 95(4): 625-630

Szelezynski K.; Kalinowska L., 1965: Correlation between toxic effects of isoniazide and rate of its inactivation in the organism abstract from pol tyg lek 20 42 1575 1577 1965 human pulmonary tuberculosis. Drug Digests (11): 37-38

Maruyama, J.; Miyahara, T., 1976: Studies on oestrus in pigs. 3. Investigation of the relationship between the ovarian cycle and signs of oestrus in sows. Histological examinations were carried out on ovarian and vaginal vestibule tissues from 12 sows in pro-oestrus, 11 sows in oestrus, 10 sows in postoestrus and 32 sows in dioestrus. Pro-oestrus coincided with the late follicular and early luteal p...