geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The effect of the molecular adsorbent recirculating system on moxifloxacin and meropenem plasma levels


, : The effect of the molecular adsorbent recirculating system on moxifloxacin and meropenem plasma levels. Acta Anaesthesiologica Scandinavica 57(4): 461-467

Adequate plasma antibiotic concentrations are necessary for effective elimination of invading microorganism; however, extracorporeal organ support systems are well known to alter plasma concentrations of antibiotics, requiring dose adjustments to achieve effective minimal inhibitory concentrations in the patient's blood. A mock molecular adsorbent recirculating system (MARS) circuit was set using 5000?ml of bovine heparinized whole blood to simulate an 8-h MARS treatment session. After the loading dose of 400?mg of moxifloxacin or 2?g of meropenem had been added, blood was drawn from the different parts of the MARS circuit at various time points and analyzed by high-performance liquid chromatography. The experiments were performed in triplicate. Additionally, meropenem concentrations were determined in the plasma of one patient treated with MARS suffering from acute liver failure due to an idiosyncratic reaction to immunosuppressive medication. In our single-compartment model, a significant decrease in the quasi-systemic concentration of moxifloxacin and meropenem could be detected as early as 15?min after the commencing of the MARS circuit. Moreover, within 60?min the moxifloxacin and meropenem concentrations were less than 50% of the initial value. The activated charcoal removed the majority of moxifloxacin and meropenem in the albumin circuit. In our patient, the meropenem concentrations in the return line after MARS were constantly lower than in the access line, indicating a likely removal of meropenem through MARS. Our data provide evidence that moxifloxacin and meropenem are effectively removed from the patient's blood by MARS, leading to low plasma levels. Dose adjustments of both antibiotic compounds may be required.

US$19.90

PMID: 23237505

DOI: 10.1111/aas.12041


Other references

Gauze, G.F., 1960: Some results of our visit to the USA. Vestnik Akademii Meditsinskikh Nauk SSSR 15(3): 78-82

Walls A.W.G.; Wassell R.W.; Steele J.G., 1991: A comparison of two methods for locating the intercuspal position icp while mounting casts on an articulator. The accuracy of two different techniques for locating casts in the intercuspal position (ICP) in a semi-adjustable articulator was assessed. The techniques for establishing the ICP were a polyether interdental registration, or location of the cast...

Goodale D.B.; Moore K.E., 1973: In vivo release of tritiated dopamine from cat brain by benztropine. Pharmacologist 15(2): 174

Bohn, J M., 2004: On two abyssal Myriotrochidae new to the South Atlantic (Holothuroidea: Apodida). Unknown

Norman, A.W.; Haussler, M.R.; Adams, T.H.; Myrtle, J.F.; Roberts, P.; Hibberd, K.A., 1969: Basic studies on the mechanism of action of vitamin D. American Journal of Clinical Nutrition 22(4): 396-411

Benitez Rodriguez, R., 1998: Jose Luis Gonzalez Castro 1916-1997. Research and Reviews in Parasitology. June; 582: 151-152

Conde B., 1991: Prokoenenia millotorum remy type species of the new genus triadokoenenia new genus arachnida palpigradida. A new examination of the malagasy Palpigrade Prokoenenia millotorum Remy leads to the erection of TRIADOKOENENIA n. gen. on the basis of two exclusive characters: the loss of the mid frontal organ and a third pair of spinnerets in male.

Sarkisova, T.; Petrzik, K., 2011: Determination of the complete nucleotide sequence of a lupine potyvirus isolate from the Czech Republic reveals that it belongs to a new member of the genus Potyvirus. The complete nucleotide sequence of the ssRNA genome of a lupine potyvirus (LP) isolate was determined. It comprised 10,113 nucleotides excluding the poly(A) tail. Phylogenetic analysis of CP protein sequences identified pepper veinal mottle virus...

Boyanov, M.; Bakalov, D.; Boneva, Z., 2010: Bone mineral density in men with and without the metabolic syndrome. The objective of this study was to measure bone mineral density (BMD) in middle-aged men with and without the metabolic syndrome according to the International diabetes federation (IDF) definition from 2005. We studied 80 men (mean age: 51.9 +/- 9...

Vacelet, J.; Garrone, R., 1985: Two distinct populations of collagen fibrils in a 'sclerosponge' (Porifera). NATO ASI (Advanced Science Institutes) Series Series A Life Sciences, 93: 183-189