+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Enteral immunonutrition versus standard enteral nutrition for patients undergoing oesophagogastric resection for cancer

, : Enteral immunonutrition versus standard enteral nutrition for patients undergoing oesophagogastric resection for cancer. International Journal of Surgery 11(2): 122-127

A best evidence topic in surgery was written according to a structured protocol. The question addressed was In cancer patients undergoing oesophageal or gastric resection for cancer and requiring postoperative nutritional support, does enteral immunonutrition confer additional clinical benefits as compared to standard enteral nutrition? Two hundred and fifty-eight papers were identified by a search of the MEDLINE and EMBASE databases, of which six randomized controlled trials represented the best evidence to answer this clinical question. The authors, journal, date and country of publication, patient group, study group, relevant outcomes and results of these papers were tabulated. All six of these randomised controlled trials compared the clinical benefits of standard enteral nutrition with those of enteral nutrition supplemented with a variety of immune-modulating substances. The studies failed to demonstrate consistent differences in patients' postoperative clinical course, complications, length of hospital stay and inflammatory marker levels. Hence although there is reasonable evidence to suggest that immunonutrition improves humoral immunity as opposed to cellular immunity. However, this improvement in humoral immunity does not result in reductions in infection rates or reduced hospital stay. There is currently not enough evidence to recommend routine immunonutrition in all patients undergoing oesophageal or gastric resection for cancer.


PMID: 23274278

DOI: 10.1016/j.ijsu.2012.12.012

Other references

Rubsamen, D.S., 1974: Right to refuse blood transfusion. Medical World News 15(17): 58-58

Pickard, C.E.; Stewart, A.D.; Hartley, R.; Lucock, M.D., 1986: A rapid HPLC method for monitoring plasma levels of caffeine and theophylline using solid phase extraction columns. A simple HPLC method for the determination of caffeine and theophylline in plasma is described. Separation of theobromine, paraxanthine, theophylline, beta-hydroxyethyltheophylline and caffeine is obtained using a mobile phase of 1% acetic acid/me...

Lavenseau, L., 1971: Experimental behavior of alar morphogenetic areas of two Lepidoptera: Bombyx mori L. and Lymantria dispar L. Archives de zoologie experimentale et generale: 12 (4) 649-652

Howorth, M.B., 1943: Evolution Of Spinal Fusion. Annals of Surgery 117(2): 278-289

Hoell, T.; Huschak, G.; Beier, A.; Holzhausen, H-Juergen.; Meisel, H-Joerg.; Emmrich, F., 2011: Vertebral osteoporosis: perfused animal cadaver model for testing new vertebroplastic agents. Experimental study. It was aimed to establish a cadaver model to imitate osteoporotic perfused vertebral bone and to allow for transpedicular transfer of bone cement and various new materials into vertebrae. The model was perfused to simulate vert...

Wisden W.; Morris B.J.; Darlison M.G.; Hunt S.P.; Barnard E.A., 1989: Localization of gaba a receptor alpha subunit messenger rna in relation to receptor subtypes. The distribution of 3 GABAA receptor .alpha.-subunit mRNAs in various regions of bovine brain has been investigated using in situ hybridization. Whereas the .alpha.2- and .alpha.3-transcripts are of low abundance in all regions except striatum, th...

Urguev, K.R., 1972: Bacillary carrier state in infectious enterotoxemia of sheep. Veterinariia 48(3): 54-56

Faĭman, B.A.; Mikhaĭlov, V.Ia.; Marenko, V.F., 1980: Lupus tuberculosis of the upper respiratory tracts. Vestnik Otorinolaringologii: 57-58

Furst, M.; Eyal, S.; Korczyn, A.D., 1990: Prediction of binaural click lateralization by brainstem auditory evoked potentials. A previous study by Furst et al. (1985) has shown that in healthy subjects brainstem responses evoked by binaural auditory stimuli with interaural time difference (ITD) and interaural level difference (ILD) include information about the integratio...

Gerlach, Albrecht, 2004: Euphrasia frigida im Harz. Euphrasia frigidu has been recorded from most of the northern German mountain range, but not from the Harz-Mountains. This gap has now been closed.