geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The role of 'mineralocorticoids' in teleost fish: relative importance of glucocorticoid signaling in the osmoregulation and 'central' actions of mineralocorticoid receptor


, : The role of 'mineralocorticoids' in teleost fish: relative importance of glucocorticoid signaling in the osmoregulation and 'central' actions of mineralocorticoid receptor. General and Comparative Endocrinology 181: 223-228

It has long been held that cortisol, a glucocorticoid in many vertebrates, performs glucocorticoid and mineralocorticoid actions in the teleost fish since it lacks aldosterone. However, in addition to the counterparts of tetrapod mineralocorticoid receptors (MRs), 11-deoxycorticosterone (DOC) has been recently identified as a specific endogenous ligand for the MRs in teleosts. Here, we point out the minor role of mineralocorticoid signaling (i.e., DOC-MR) in the osmoregulation compared with those of glucocorticoid signaling (i.e., cortisol glucocorticoid receptor [GR]), and review the current findings on the physiological roles of the DOC-MR in teleosts. Cortisol promotes both freshwater and seawater adaptation via the GRs in the osmoregulatory organs such as gills and gastrointestinal tracts, but the expressions of MR mRNA are abundant in the brains especially in the key components of the stress axis and cerebellums. Together with the behavioral effects of intracerebroventricular injection with DOC, the MR is suggested to play an important role in the brain dependent behaviors. Since the abundant expression of central MRs has been reported also in higher vertebrates and the MR is thought to be ancestral to the GR, the role of MR in fish might reflect the principal and original function of corticosteroid signaling. Functional evolution of corticosteroid systems is summarized and areas in need of research like our on-going experiments with MR-knockout medaka are outlined. As a specific endogenous ligand for teleost MR, DOC has been recently identified. Physiological roles of mineralocorticoid systems in teleosts are reviewed. Cortisol-GRs seem to be more important for the osmoregulation than DOC-MR. Roles of DOC-MR appear to be in brain-behavior. Functional evolution of corticosteroid systems and future perspectives are summarized.

US$19.90

PMID: 23220000

DOI: 10.1016/j.ygcen.2012.11.016


Other references

Stoolmiller, M., 1999: Correcting estimates of shared environmental variance for range restriction in adoption studies using a truncated multivariate normal model. A model is presented for the truncated trivariate normal distribution that arises in behavior genetic adoption designs that focus on sibling similarity to estimate shared environmental effects. The model estimates the point of truncation and share...

Sakai, H.; Yagi, K.; Kobayashi, K.; Kawashima, S., 2001: Rice carbon balance under elevated CO2. Season-long effects of elevated CO2 concentration ([CO2]) on the carbon balance of the rice (Oryza sativa) canopy are reported here. The experiment was conducted in six sunlit, semiclosed growth chambers for an entire growing season. Rice (cv. Nip...

Li; Quinn; Li; Tian; Jona; Marcus, 1991: Multilayer relaxation of clean Ag{001}. Physical Review. B, Condensed Matter 43(9): 7305-7307

Furukawa, C.; Morioka, I., 2017: Health-Related Quality of Life and Sleep Disorders in Patients With a Urostomy: Is There a Relationship?. The purpose of this study was to evaluate the relationship between health-related quality of life (HRQOL) and sleep disorders in persons living with a urostomy. A cross-sectional descriptive study. Eighty-six adults with a urostomy who were cared...

Davies Michael; Martin Todd; Lighthall Peter, 2000: Tailings dam stability; essential ingredients for success. Pages 365-377 2000

Phipatanakul, W.; Litonjua, A.A.; Platts-Mills, T.A.E.; Naccara, L.M.; Celedón, J.C.; Abdulkerim, H.; Hoffman, E.B.; Gold, D.R., 2007: Sensitization to mouse allergen and asthma and asthma morbidity among women in Boston. Journal of Allergy and Clinical Immunology 120(4): 954-956

Günaldi, M.; Helvaci, Aşen.; Yildirim, N.Demirel.; Kiskaç, M.; Küçükkaya, R.Diz., 2009: Acute myocardial infarction in a patient with hemophilia A and factor V Leiden mutation. Factor VIII:C, epsilon amino-caproic acid or tranexamic acid are prophylactic agents used in preventing hemorrhage pre-operatively in patients with hemophilia A. Although hemophilia A seems to be a factor that avoids the development of acute myoca...

Dharmarajan, T.S.; Pais, W.; Norkus, E.P., 2005: Does anemia matter? Anemia, morbidity, and mortality in older adults: need for greater recognition. Anemia is common and under recognized in older adults and associated with increased morbidity and mortality. Estimates of prevalence of anemia in older adults vary considerably based on the setting, gender, age and definition used and likely to in...

Selihovskii, S.S., 1969: Meat characters of Grozny sheep. Data are tabulated, separately for each of 3 skin-fold types, on carcass and meat characters of 10 yearling, 10 ewes and 10 wethers.

Penela, D.; Van Huls Van Taxis, C.; Van Huls Vans Taxis, C.; Aguinaga, L.; Fernández-Armenta, J.; Mont, L.; Castel, M.Angels.; Heras, M.; Tolosana, J.María.; Sitges, M.; Ordóñez, A.; Brugada, J.; Zeppenfeld, K.; Berruezo, A., 2013: Neurohormonal, structural, and functional recovery pattern after premature ventricular complex ablation is independent of structural heart disease status in patients with depressed left ventricular ejection fraction: a prospective multicenter study. This study aimed to assess the benefit after ablation of premature ventricular complexes (PVC) in patients with frequent PVC and left ventricular (LV) dysfunction, regardless of previous structural heart disease (SHD) diagnosis, PVC morphology, or...