+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Imaging work-up for screening of paraganglioma and pheochromocytoma in SDHx mutation carriers: a multicenter prospective study from the PGL.EVA Investigators

, : Imaging work-up for screening of paraganglioma and pheochromocytoma in SDHx mutation carriers: a multicenter prospective study from the PGL.EVA Investigators. Journal of Clinical Endocrinology and Metabolism 98(1): E162-E173

Recommendations have not been established concerning imaging to screen SDHx mutation carriers for paraganglioma and pheochromocytoma.Our objective was to compare the performance of gadolinium-enhanced magnetic resonance angiography, contrast-enhanced computed tomography, and [123I]metaiodo-benzylguanidine and somatostatin receptor scintigraphies for detecting head and neck and thoracic-abdominal-pelvic paragangliomas in SDHx mutation carriers. and We conducted a prospective, multicenter study from June 2005 to December 2009 at 23 French medical centers. A total of 238 index cases or relatives carrying mutations in SDHD, SDHB, or SDHC genes were included.Intervention:Images obtained by each technique were analyzed blind, without knowledge of results from other tests, first in each local center and then centrally.Main Outcome Measures:We evaluated sensitivity, specificity, and likelihood ratios for individual and combinations of tests, the gold standard being the consensus of an expert committee. Two hundred two tumors were diagnosed in 96 subjects. At local assessment, the sensitivity of anatomical imaging for detecting all tumors was higher (85.7%) than that of both scintigraphic techniques (42.7% for [123I]metaiodo-benzylguanidine and 69.5% for somatostatin receptor scintigraphy), except for thoracic localizations where somatostatin receptor scintigraphy was more sensitive (61.5 vs. 46.2% for anatomical imaging and 30.8% for [123I]metaiodo-benzylguanidine scintigraphy). The best diagnostic performance during local assessment was obtained by combining anatomical imaging tests and somatostatin receptor scintigraphy (sensitivity 91.7%). Central assessment significantly increased the sensitivity (98.6%) of tests in combination. In routine practice, the imaging work-up for screening SDHx mutation carriers should include thoraco-abdomino-pelvic computed tomography, head and neck magnetic angiography, and somatostatin receptor scintigraphy. Expert centralized image assessment is recommended.


PMID: 23162105

DOI: 10.1210/jc.2012-2975

Other references

Vitze, H.; Lerner, H-Wolfram.; Bolte, M., 2009: Dibromidotris(dimethyl-amine)magnesium(II). The Mg centre in the title compound, [MgBr(2)(C(2)H(7)N)(3)], is penta-coordinated in a trigonal-bipyramidal mode with the two Br atoms in axial positions and the N atoms of the dimethyl-amine ligands in equatorial positions. The Mg(II) centre is...

Wang, Y.Z.; Li, Z.Y., 2002: Inflorescence development of Whytockia (Epithemateae, Gesneriaceae) and phylogenetic implications within Gesneriaceae. The inflorescence development in Whytockia has been studied in order to explore the developmental basis for inflorescence architecture. The developmental pattern of the pair-flowered cyme in Whytockia basically conforms to that of most members in...

Lesage, A.; Morisette, R., 1989: Residential resources necessary to the pursuit of deinstitutionalization.. A survey was conducted amongst physicians responsible for long term inpatients of Louis-H. Lafontaine mental hospital. Physicians were asked to identify patients with a potential for resettlement outside the hospital. A random sample of 300 patien...

Luna, C.A.; Glinberg, E.; Pastorini, J.M.; D.S.hor, G.; Díaz, R., 1969: Personal management of residual hepatic duct and choledochus lithiasis. Prensa Medica Argentina 56(23): 1102-1104

Murphy, J.B.; Sturm, E., 1933: Effect Of Inhibiting Factor From Normal Tissues On Spontaneous Tumors Of Mice. Science 77(2009): 631-633

Pan, X.; Curran, D.P., 2014: Neutral sulfur nucleophiles: synthesis of thioethers and thioesters by substitution reactions of N-heterocyclic carbene boryl sulfides and thioamides. Newly discovered boryl sulfides and N-borylthioamides are shown to serve as neutral sources of sulfur nucleophiles in substitutions reactions. For example, heating of diMe-Imd-BH(SPh)2 with benzyl bromides, primary bromides, or acid chlorides prov...

Tarjan, A.C.; Ford, H.W., 1957: A modified aceto-osmium staining method for demonstration of nematodes in citrus root tissues. In this technique for demonstrating nematodes in plant tissue, citrus roots, fresh or preserved, are immersed for two hours at 52 degrees C. in a covered jar in a solution of 16 parts distilled water, ten parts 10% acetic acid and two parts 2% aqu...

Brodal, P.; Brodal, A., 1982: Further observations on the olivocerebellar projection in the monkey. The distribution of retrogradely labeled cells in the inferior olive was studied following cerebellar injections of horseradish peroxidase in four experiments in macaque monkeys. The flocculus was found to receive its main projection from the dors...

Abbruzzetti, S.; Viappiani, C.; Chen, Y.; Small, J.R.; Libertini, L.J.; Small, E.W., 1999: Photoacoustic detection of protein unfolding on microsecond and submicrosecond time scales. Biophysical Journal 76(1 PART 2): A169, Jan

Honey M.; Cotter L.; Davies N.; Denison D., 1980: Clinical and hemodynamic effects of diazoxide in primary pulmonary hypertension. Diazoxide was injected into the pulmonary artery in 9 patients with primary pulmonary hypertension. There was no significant change in pulmonary artery pressure, which fell by more than 10 mm Hg in only 2 patients. The pulmonary blood flow increas...