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Low intensity vs. self-guided internet-delivered psychotherapy for major depression: a multicenter, controlled, randomized study


, : Low intensity vs. self-guided internet-delivered psychotherapy for major depression: a multicenter, controlled, randomized study. Bmc Psychiatry 13: 21-21

Major depression will become the second most important cause of disability in 2020. Computerised cognitive-behaviour therapy could be an efficacious and cost-effective option for its treatment. No studies on cost-effectiveness of low intensity vs self-guided psychotherapy has been carried out. The aim of this study is to assess the efficacy of low intensity vs self-guided psychotherapy for major depression in the Spanish health system. The study is made up of 3 phases: 1 Development of a computerised cognitive-behaviour therapy for depression tailored to Spanish health system. 2 Multicenter controlled, randomized study: A sample (N=450 patients) with mild/moderate depression recruited in primary care. They should have internet availability at home, not receive any previous psychological treatment, and not suffer from any other severe somatic or psychological disorder. They will be allocated to one of 3 treatments: a) Low intensity Internet-delivered psychotherapy + improved treatment as usual (ITAU) by GP, b) Self-guided Internet-delivered psychotherapy + ITAU or c) ITAU. Patients will be diagnosed with MINI psychiatric interview. Main outcome variable will be Beck Depression Inventory. It will be also administered EuroQol 5D (quality of life) and Client Service Receipt Inventory (consume of health and social services). Patients will be assessed at baseline, 3 and 12 months. An intention to treat and a per protocol analysis will be performed.DiscussionThe comparisons between low intensity and self-guided are infrequent, and also a comparative economic evaluation between them and compared with usual treatment in primary. The strength of the study is that it is a multi-centre, randomized, controlled trial of low intensity and self-guided Internet-delivered psychotherapy for depression in primary care, being the treatment completely integrated in primary care setting.

US$19.90

PMID: 23312003

DOI: 10.1186/1471-244X-13-21


Other references

Schmidt, M.K.; van den Broek, A.J.; Tollenaar, R.A.E.M.; Smit, V.T.H.B.M.; Westenend, P.J.; Brinkhuis, Mël.; Oosterhuis, W.J.W.; Wesseling, J.; Janssen-Heijnen, M.L.; Jobsen, J.J.; Jager, A.; Voogd, A.C.; van Leeuwen, F.E.; van 't Veer, L.J., 2017: Breast Cancer Survival of BRCA1/BRCA2 Mutation Carriers in a Hospital-Based Cohort of Young Women. Label="Background">The primary aim of the study was to investigate prognosis and long-term survival in young breast cancer patients with a BRCA1 or BRCA2 germline mutation compared with noncarriers. The secondary aim was to investigat...

Patalas, J.; Patalas, K., 1966: The crustacean plankton communities in Polish Lakes. Verhandlungen Internationalen Vereinigung Limnologie, 16: 204-215

Nakazawa, K.; Nakazawa, H.; Bonnard, M.; Damour, O.; Collombel, C., 1995: Ca-2+ and UVB radiation have no effect on E-cadherin-mediated melanocyte-keratinocyte adhesion. Direct cell-cell contact between melanocytes and keratinocytes has been shown to play an important role in the regulation of human melanocyte function and skin pigmentation. An important role for the calcium-dependent epithelium-specific cell adhe...

Kim, M-Kyoung.; Lee, S.; Kim, E.Ju.; Kong, K.Hwan.; Lee, D.Hun.; Chung, J.Ho., 2013: Topical application of anacardic acid (6-nonadecyl salicylic acid) reduces UV-induced histone modification, MMP-13, MMP-9, COX-2 and TNF-α expressions in hairless mice skin. Journal of Dermatological Science 70(1): 64-67

Werch, S.C., 1956: The problem of the internship. Mississippi Valley Medical Journal 78(5): 210-213

Miller, H.C.; Collins, L.A.; Turbow, A.M.; Turbow, B.A.; Beall, M.E.; Berger, R.M.; Lebowitz, J.M.; Young, I.S.; Kahn, R.I.; Karol, J.B., 1989: Initial EDAP LT-01 lithotripsy group experience in the United States. The initial United States cooperative experience with the EDAP LT-01 second generation piezoelectric extracorporeal shock wave lithotriptor using ultrasonic guidance is presented. Particular to the machine are lack of radiation exposure, no need f...

Pou D.C.escenzo, M.A.ne; Goto, K.; Carre, I.A.; Laval Martin, D.L., 1997: Regulation of a NAD+ activity isolated from asynchronous cultures of the achlorophyllous ZC mutant of Euglena gracilis. NAD+ kinase was isolated by chromatography steps from asynchronous cultures of the achlorophyllous ZC mutant of Euglena gracilis. A non Ca2+-calmodulin dependent form, whose activity was stimulated by EGTA, was selected for its large quantity and...

Silveri, M.M.; Dikan, J.; Ross, A.J.; Jensen, J.E.; Kamiya, T.; Kawada, Y.; Renshaw, P.F.; Yurgelun-Todd, D.A., 2008: Citicoline enhances frontal lobe bioenergetics as measured by phosphorus magnetic resonance spectroscopy. Citicoline supplementation has been used to ameliorate memory disturbances in older people and those with Alzheimer's disease. This study used MRS to characterize the effects of citicoline on high-energy phosphate metabolites and constituents...

Clift, A.D.; Smart, P., 1976: The effect of nine keto trans two decenoic acid on the ovaries of two species of Cyclorrhaphous Diptera. The honeybee queen substance (E)-9-oxo-2-decenoic acid, which prevents the development of the ovaries of worker bees, was applied topically to adults of Dacus tryoni (Frogg.) and Lucilia cuprina (Wied.). The substance was shown to have an effect o...

Aleman-Garcia, M.Angel.; Orbach, R.; Willner, I., 2015: Ion-responsive hemin-G-quadruplexes for switchable DNAzyme and enzyme functions. Programmed nucleic acid sequences undergo K(+) ion-induced self-assembly into G-quadruplexes and separation of the supramolecular structures by the elimination of K(+) ions by crown ether or cryptand ion-receptors. This process allows the switchab...