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Chemical constituents and antiulcerogenic potential of scales of Cynara scolymus heads

, : Chemical constituents and antiulcerogenic potential of scales of Cynara scolymus heads. Journal of the Science of Food and Agriculture

Cynara scolymus L. (Asteraseae), is commonly eaten as a vegetable; its leaves are frequently used in folk medicine in treatment of hepatitis, hyperlipidemia, obesity, and dyspeptic disorders. The purpose of this study is to determine the chemical composition of volatile oil and alcoholic extract of artichoke head scales. In addition the role of the methanol extract on acute gastric antiulcer against ethanol-induced gastric ulcer in rats was evaluated. Six flavonoids and one phenolic acid were obtained from the methanol extract. Also, thirty seven compounds were identified in the volatile oil, the majority including mono and sesquiterpenes. The artichoke extracts (200 and 400 mg/kg) significantly (P<0.05) reduced the ulcer index (55.33% &72.14% inhibition). Histopathological examination of rat stomachs demonstrated that artichoke induced an increase in gastric mucus production, reduction of the depth and severity of mucosal lesions. Artichoke dose-dependently reduced the elevated ethanol gastric MDA, GSH levels and CAT activity. These results suggest that the head scales of artichoke possess potential antiulcer activity. The present research article describes the identification of volatile oil for the first time along with the isolation and identification of the constituents of methanol extract. Moreover, highly antiulcerogenic potential of scales of Cynara scolymus heads was established here in for the first time.


DOI: 10.1002/jsfa.6065

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