+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The association of adipokine levels in plasma and synovial fluid with the severity of knee osteoarthritis

, : The association of adipokine levels in plasma and synovial fluid with the severity of knee osteoarthritis. Rheumatology 52(6): 1077-1083

We sought to determine the association between plasma and SF levels of leptin and adiponectin in patients with knee OA. . Plasma and SF levels of adipokines and soluble leptin receptor (sOB-R) were determined by ELISA in 96 patients with knee OA at different stages, according to Ahlback’s classification. Levels of adiponectin, leptin, sOB-R and free leptin in plasma and SF did not differ significantly across categories of OA severity. However, the ratio of SF to plasma leptin was significantly lower in the advanced OA stage compared with early stages of the disease (P = 0.02). After adjustment for sex and BMI, plasma leptin positively correlated with categories of OA severity (r = 0.23, P = 0.02), whereas SF/plasma leptin negatively correlated with OA stage (r = –0.27, P = 0.01). Cluster analysis showed that all men were included in one cluster and distributed in different stages of OA, whereas women formed three clusters with similar BMI, but those who were older and had the highest plasma leptin levels suffered from advanced OA. Plasma leptin positively correlated with the severity of knee OA. The ratio of SF to plasma leptin might be a marker related to the severity of knee OA. Further studies should investigate whether similar associations exist in other joints affected by OA.


PMID: 23382357

DOI: 10.1093/rheumatology/kes422

Other references

Romero Conesa, P., 1950: Bilateral combined collapsotherapy: thoracoplasty and pneumothorax. Medicina Espanola 23(134): 415-431

Yaskevich, T.F., 1972: Biochemical indications in the meat of geese infected with cestodes, nematodes and trematodes. The author compares the pH, peroxidase activity, reaction for polypeptides and test for amino-ammonium nitrogen and catalase activity in meat from healthy geese with that from geese with light and heavy infections of nematodes, cestodes and tremat...

Wilkinson, J.D.; Wood, E.N., 1981: 3-nitro toxicity in pigs. Veterinary Record 109(15): 343-343

Goodrich, J.K.; Stone, H.L.; Harris, C.C.; Hill, R., 1965: Clinical Applications Of Low-Energy High Transmission Collimator. Journal of Nuclear Medicine 6: 409-420

E.H.fnawi E.; Laqua H.; Bopp S.; Bornfeld N., 1987: Histological study of epiretinal and subretinal tissue strands with and without silicone oil injection. Acta Anatomica 130(1): 27

Huang, K.; Ghose, R.; Flanagan, J.M.; Prestegard, J.H., 1999: Backbone dynamics of the N-terminal domain in E. coli DnaJ determined by 15N- and 13CO-relaxation measurements. The backbone dynamics of the N-terminal domain of the chaperone protein Escherichia coli DnaJ have been investigated using steady-state 1H-15N NOEs, 15N T1, T2, and T1r relaxation times, steady-state 13Ca-13CO NOEs, and 13CO T1 relaxation times. T...

Spasovski, G., 2008: New strategies in treatment of mineral and bone disorders and associated cardiovascular disease in patients with chronic kidney disease. Mineral and bone disorders in chronic kidney disease (CKD) patients along with the use of calcium-based phosphate binders may result in vascular calcification (VC) development and associated increase in cardiovascular diseases (CVD) mortality. A f...

Alvarez-Ginarte, Y.María.; Crespo-Otero, R.; Marrero-Ponce, Y.; Noheda-Marin, P.; Garcia de la Vega, J.Manuel.; Montero-Cabrera, L.Alberto.; Ruiz García, Jé.Alberto.; Caldera-Luzardo, Jé.A.; Alvarado, Y.J., 2008: Chemometric and chemoinformatic analyses of anabolic and androgenic activities of testosterone and dihydrotestosterone analogues. Predictive quantitative structure -activity relationship (QSAR) models of anabolic and androgenic activities for the testosterone and dihydrotestosterone steroid analogues were obtained by means of multiple linear regression using quantum and phy...

Mincu, I.; Erich, G.B., 1973: Current concepts concerning the genetic transmission of diabetes mellitus; I. Medicina Interna 25(8): 899-914

Dower, A.; Chatterji, R.; Swart, A.; Winder, M.J., 2016: Surgical management of recurrent lumbar disc herniation and the role of fusion. This systematic review was performed to evaluate the various operative management strategies for recurrent lumbar disc herniation (RLDH), including the efficacy of instrumented spinal fusion (ISF) at repeat discectomy, and whether the operative ap...