+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Telomere length in patients with systemic lupus erythematosus and its associations with carotid plaque

, : Telomere length in patients with systemic lupus erythematosus and its associations with carotid plaque. Rheumatology 52(6): 1101-1108

To evaluate telomere length (TL) between patients with SLE and healthy controls and to test if TL is associated with carotid plaque. . A pilot study of 154 patients with SLE and 152 controls was performed from the SOLVABLE (Study of Lupus Vascular and Bone Long-Term Endpoints) cohort. Demographic and cardiovascular disease (CVD) factors were collected at baseline. The presence or absence of plaque was evaluated by B-mode US. Genomic DNA was isolated from whole peripheral blood. TL was quantified using real-time quantitative PCR. SLE women had a short TL compared with healthy controls (4.57 vs 5.44 kb, P = 0.03). SLE women showed shorter TL than controls across all age groups: <35 years (4.38 vs 6.37 kb), 35–44 years (4.52 vs 5.30 kb), 45–54 years (4.77 vs 5.68 kb) and ≥55 years (4.60 vs 4.71 kb). Among patients with SLE and carotid plaque there was a trend towards shorter TL at a younger age and it was significantly lower in the 35- to 44-year age group when compared with controls (P = 0.025). Multiple logistic regression analysis indicated a risk of carotid plaque with older age [odds ratio (OR) 1.09; 95% CI 1.06, 1.12] but not with TL (OR 1.05; 95% CI 0.97, 1.13). SLE women had significantly shorter TL than controls. SLE women trended towards shorter TL at a younger age. When carotid plaque was identified, the younger SLE women had shorter TL. Only older age but not shorter TL was independently associated with carotid plaque. Additional studies are needed to confirm if TL is a novel biomarker for cardiovascular disease in SLE.


PMID: 23382361

DOI: 10.1093/rheumatology/kes424

Other references

Lorimer R.I., 1988: The lepidoptera of the orkney islands scotland uk supplement 1983 1987. Entomologist's Gazette 39(3): 181-186

McLellan, A.Thomas., 2006: Communicating across the "chasm": Journal of Substance Abuse Treatment and Counselor initiate cooperative agreement. Journal of Substance Abuse Treatment 31(1): 1-1

Thomas, MD., 1982: A radio telemetry system for animal tracking in New Zealand. A radio telemetry system has been developed to monitor movements of the brushtailed possum, hare, and feral goat in different New Zealand habitats. Remote tracking using 2 fixed receiving stations simultaneously tuned to transmitters with individu...

Pokorny, J.J.melka, I.D.videk, J.D.usova, J.B.lantova, H., 1981: Chemical changes in dehydrated soups during storage. Prumysl potravin: Technika a ekonomika prumyslove vyroby potravin 32(9): 485-487

Lees, R.E., 1966: Malnutrition: the infant at risk. Following the reduction in the number of deaths from undernutrition in young children in St. Lucia, a simple survey was conducted to define the socio-economic factors, if any, responsible for the persistence of a hard core of cases of undernutriti...

Venables, W.A.; Guest, J.R., 1968: Transduction of enz nitrate reductase loci of escherichia coli by phages p 1 and lambda. Molecular and General Genetics 103(2): 127-140

Lindskog S.; Ahren B., 1991: Studies on the mechanisms whereby galanin inhibits insulin secretion in rat islets. Acta Endocrinologica Supplementum 124(3): 22

Dang, K., 1981: Intracellular symbiotes and their functions in Sitophilus oryzae L. Nutrition, symbiosis. Insect physiology and anatomy: summer institute lectures edited by N C Pant and Swaraj Ghai: 255

Sarazin, MJ., 1990: Insect liberations in Canada. Parasites and predators 1989. A summary of parasite and predator shipments made in Canada in 1989, including tables of insect liberations made against noxious weeds and the shipment of beneficial insects to foreign countries. Agriculture Canada Liberation Bulletin, 1-47, 1-52 No. 53

Isler, O.; Lindlar, H.; Montavon, M.; Ruegg, R.; Zeller, P., 1956: Syntheses in the carotenoid series. 1. The industrial synthesis of beta -carotene. The commercial synthesis of beta -carotene is described. The synthetic beta -carotene was compared with natural beta -carotene for melting-point, elementary analysis, shape of crystals, and other characteristics. Each chemical and physical constan...