+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Attenuated TGF-β1 responsiveness of dendritic cells and their precursors in atopic dermatitis

, : Attenuated TGF-β1 responsiveness of dendritic cells and their precursors in atopic dermatitis. European Journal of Immunology 43(5): 1374-1382

The responsiveness of DCs and their precursors to transforming growth factor beta1 (TGF-β1) affects the nature of differentiating DC subsets, which are essential for the severity of atopic dermatitis (AD). To evaluate TGF-β signaling in monocytes and monocyte-derived DCs of AD patients compared with that of controls, in vitro generated Langerhans cell (LC) like DCs, expression of TGF-β receptors, phospho-Smad2/3 and Smad7 were evaluated. Furthermore, TNF-α expression and synergistic effects of TNF-α upon TGF-β signaling and DC generation were evaluated. We found LC-like DC differentiation of monocytes from AD patients in response to TGF-β1 was remarkably reduced and TGF-β1 receptor expression was significantly lower compared with that of healthy controls. Attenuated TGF-β1 responsiveness mirrored by lower phospho-Smad2/3 expression after TGF-β1 stimulation and higher expression of inhibitory Smad7 was observed in monocytes from AD patients. During DC generation, mRNA expression of Smad7 was relatively higher in LC-like DCs of AD patients. Lower TNF-α expression of monocytes from AD patients might further contribute to attenuated TGF-β signaling in the disease since TNF-α had synergistic effects on TGF-β1 signaling and LC generation through mediating the degradation of Smad7. Our results demonstrate alleviated TGF-β1 signaling together with the amount of soluble co-factors might direct the nature of differentiating DCs.


PMID: 23436698

DOI: 10.1002/eji.201242955

Other references

Berkowitz, L., 1990: On the formation and regulation of anger and aggression. A cognitive-neoassociationistic analysis. Noting that a wide variety of unpleasant feelings, including sadness and depression, apparently can give rise to anger and aggression, I propose a cognitive-neoassociationistic model to account for the effects of negative affect on the development...

O'connor, W.J., 1950: The role of the neurohypophysis of the dog in determining urinary changes, and the anti-diuretic activity of urine, following the administration of sodium chloride or urea. Anti-diuretic activity in urine of dogs was detected and assayed by inhibition of water diuresis in a test dog when injd. intraven. Urine collected following the admn. of 60-100 ml. of 3-5% NaCl by stomach tube contained anti-diuretic activity equ...

Oepen, H., 1961: On the diagnostic value of psychiatric findings in temporal brain tumors. Archiv für Psychiatrie und Nervenkrankheiten, Vereinigt Mit Zeitschrift für die Gesamte Neurologie und Psychiatrie 201: 465-482

Anonymous, 2013: Court rules that exemption from smoking ban for small Dutch cafes is unlawful. An exception to the smoking ban in the Netherlands allowing people to light up in small cafes is unlawful, according to a landmark legal ruling by the appeal court in The Hague. The court ruled that.

Anonymous, 2006: Are blood pressure machines in drugstores and shopping malls accurate?. Mayo Clinic Women's Healthsource 11(1): 8-8

Hird, R.Barry.; Chang, A.; Cimmino, V.; Diehl, K.; Sabel, M.; Kleer, C.; Helvie, M.; Schott, A.; Young, J.; Hayes, D.; Newman, L., 2006: Impact of estrogen receptor expression and other clinicopathologic features on tamoxifen use in ductal carcinoma in situ. BACKGROUND. Recent data have demonstrated that benefit from adjuvant tamoxifen therapy for patients with ductal carcinoma in situ (DCIS) is limited to estrogen receptor (ER)-positive lesions. The objective of the current study was to correlate cli...

Gerbode, F.; Osborn, J.J.; Bramson, M.L.; Harkins, G.A.; Ross, J.K.; Johnston, J.B., 1960: Elective hypothermia during extracorporeal circulation with a new heat exchanging filming oxygenator. Indications and results. American Journal of Surgery 100: 338-345

Li, J.; Cheng, H.; Wang, K.; Deng, G., 2010: Salt tectonics in the Kuqa Foreland fold and thrust belt, Tarim Basin, northwest China. Geophysical Research Abstracts 12

Georgescu, Marius Dan, 2010: Liuenella, new name for Liuella Georgescu, 2008. Journal of Foraminiferal Research 40.2

Cima, K.; Vogelsinger, H.; Kähler, C.M., 2010: Sensory neuropeptides are potent chemoattractants for human basophils in vitro. The sensory neuropeptides secretoneurin (SN) and substance P (SP) are involved in "neurogenic" inflammatory processes as they occur in bronchial asthma or allergic rhinitis. A possible interaction with basophils has not been reported to...