+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Inhibition of human breast and colorectal cancer cells by Viburnum foetens L extracts in vitro

, : Inhibition of human breast and colorectal cancer cells by Viburnum foetens L extracts in vitro. Asian Pacific Journal of Tropical Disease 3(1): 32-36

To investigate efficacy of Viburnum foetens (V. foetens) extracts against different cancer lines. The crude extract and fractions of V. foetens are evaluated against MDA MB-468 and Caco-2 cancer cell lines by using M (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assays. These extracts are also tested against breast carcinoma and human colon adenocarcinoma through NRU (neutral red uptake) assay. The crude extract inhibited the cancerous cell growth in a dose dependent manner. From the M assay it is obvious that the ethylacetate fraction significantly inhibited the growth of Caco-2 (93.44%) cell. Similarly, the methanol and ethylacetate fractions shows 99% and 96% inhibition of MCF-7 and Caco-2 cell lines by NRU assay. Furthermore, the ethylacetate fraction also exhibited momentous inhibition of MDA MB-468 cells in both assays. Other fractions i.e. chloroform, hexane also inhibited cancer cell proliferation at a significant level. Natural products exhibited significant activity against multiple cancerous cells. In this framework, we can speculate that the present study will be helpful in the identification and isolation of novel anticancer drug compounds from the crude extract (i.e., methanol and ethyl acetate fractions) of V. foetens.


DOI: 10.1016/S2222-1808(13)60007-9

Other references

el Oakley, R.M.; Yonan, N.A.; Simpson, B.M.; Deiraniya, A.K., 1996: Extended criteria for cardiac allograft donors: a consensus study. Background and Methods: To achieve a consensus regarding extending the current criteria for referring potential cardiac allograft donor, we sent a detailed questionnaire to all heart transplant surgeons in the United Kingdom. Results: Replies repr...

Julien, M.H.R.; Soopramanien, G.C., 1976: The effect of flowering on yield in sugar cane. In a long season crop of the cvs S.17 and M.351/57, flowering stalks in a natural population had higher fresh weight and sugar yields at anthesis than vegetative stalks produced naturally or produced artificially by means of photoperiodic treatmen...

Tabata, H.; Nakajima, K., 2002: Behavior of migrating neurons during the cortical plate development. During the development of cortical plate, neurons generated in the ventricular zone migrate toward the pial surface and terminate the migration beneath the marginal zone. For long time, the only one known mode of migration had been the "locom...

Krstic, A., 1971: Role of nature in the tourism. Hortikultura 8 (1) 11-17

Likos, J.J.; Colman, R.F., 1981: Affinity labeling of rabbit muscle pyruvate kinase by a new fluorescent nucleotide alkylating agent 5'-[p-(fluorosulfonyl)benzoyl]-1,N6-ethenoadenosine. Biochemistry 20(3): 491-499

Yariv, D.; Efrat, R.; Libster, D.; Aserin, A.; Garti, N., 2010: In vitro permeation of diclofenac salts from lyotropic liquid crystalline systems. In this paper we examined feasible correlations between the structure of different lyotropic mesophases and transdermal administration of three diclofenac derivatives with varying degrees of kosmotropic or chaotropic properties, solubilized within...

Pacuta, V., 1989: Dynamics of N-NH4+ and N-NO3- changes on loamy grey-brown podzolic soil during winter wheat growth. Data on N-NH4+ and N-NO3- contents during winter wheat growth from 1982 to 1984 on a loamy grey-brown podzolic soil showed the content of both fractions of inorganic nitrogen to be higher at the 0-0.3 m depth than at 0.3-0.6 m. Manuring influenced...

Pompeo, M.L.M.; Moschini Carlos, V.; Henry, R., 1999: Growth of tropical helophyte Echinochloa polystachya (H.B.K.) Hitchcock in Jurumirim Reservoir (Sao Paulo, Brazil). The growth of the emergent macrophyte Echinochloa polystachya in the mouth of Paranapanema River at Jurumirim Reservoir (Sao Paulo, Brazil) was studied in 1993-94 through periodic measurements of living leaf blades and internodes. Successive obser...

Bianchi, V.; Ghirardo, G.; Sanguineti, M., 1959: Observations on the interaction of properdin with the complement of human sera. Minerva Medica 50: 2358-2361

Castro D.D.C.; Cicchino A.C.; Villalobos C.D., 1991: A comparative study of the external chorionic architecture of the eggs of some neotropical species of the genus hoplopleura enderlein 1904 phthiraptera anoplura. The authors describe comparatively the chorionic morphology of six Hoplopleura species: H. griseoflavae; H. scapteromydis; H. andina; H. sciuricola; H. fonsecai and H. argentina. An attempt to typify all external features present in the eggs, and...