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Protective MHC generates autoregulatory T cells


, : Protective MHC generates autoregulatory T cells.

Polymorphisms in MHC class II molecules, in particular around ?-chain position-57 (?57), afford susceptibility/resistance to multiple autoimmune diseases, including type 1 diabetes, through obscure mechanisms. Here, we show that the antidiabetogenic MHC class II molecule I-Ab affords diabetes resistance by promoting the differentiation of MHC-promiscuous autoreactive CD4+ T cells into.

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