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Contrast-enhanced CT-scan to diagnose intrahepatic cholangiocarcinoma in patients with cirrhosis


, : Contrast-enhanced CT-scan to diagnose intrahepatic cholangiocarcinoma in patients with cirrhosis.

Contrast enhanced computed tomography (CT-scan) is a standard of care for the radiological diagnosis of hepatocellular carcinoma (HCC) in patients with cirrhosis. This technique, however, is not validated to exclude intrahepatic cholangiocarcinoma (ICC) which may develop in patients with cirrhosis, as well. To assess the features of contrast CT-scan in the diagnosis of ICC, we reviewed all CT-scan films obtained in cirrhotic patients with a histologically documented ICC, taking in consideration the pattern and dynamics of the arterial, portal venous and delayed phases of contrast uptake. Thirty-two patients had 40 nodules of ICC (22 men; median age 62 years; 13 hepatitis C) that were identified either during surveillance with abdominal ultrasound (21 patients, 66%) or incidentally (11 patients, 34%). ICC was either multifocal or ? 30 mm in 11 of the former and 10 of the latter group (52% vs 91%, p<0.05). Two nodules (5%) escaped detection by CT-scan, while the remaining 38 showed a heterogeneous contrast enhancement pattern being the arterial peripheral-rim enhancement present in 19 (50%) and a progressive homogeneous contrast uptake in 16 (42%) during the three vascular phases, with no relation with tumor size. Importantly, all nodules lacked the radiological hallmark of HCC, the only ICC nodule showing a homogeneous wash-in during the arterial phase followed by a wash-out in the delayed venous phase, however showing a homogeneous wash-in during the portal phase too. ICC in cirrhotic patients displays distinct vascular patterns at CT-scan that allow for differentiation from HCC.

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Other references

Menezes, H., 1965: I. The use of adjuvants in the vaccination of mice with lyophilized "Trypanosoma cruzi". Hospital 68(6): 1341-1346

Dawson, V.; Schreier, T.; Boogaard, M.; Spanjers, N.; Gingerich, W., 2002: Rapid loss of lampricide from catfish and rainbow trout following routine treatment. Rainbow trout (Oncorhynchus mykiss) and channel catfish (Ictalurus punctatus) were exposed to 3-trifluoromethyl-4-nitrophenol (TFM) and Bayluscide (niclosamide) during a sea lamprey control treatment of the Ford River, located in the upper peninsu...

Pejchal, M.; Jurca, R., 1989: Crown regeneration in English oak (Quercus robur) before reaching the proper felling age at newly created forest borders - primary crown response (II). The post-release response of the primary crown as well as the development of a secondary crown were studied in a 114-yr-old stand and a 115-yr-old stand of Quercus robur near Zidlochovice, Czechoslovakia. A new forest margin had been created in th...

van Baaren J.P.; Ketting J., 1982: New production methods; 2, Stability of an underground coal gasification cavity. Geologie en Mijnbouw 61(4): 377-381

Agrawal, S.; Bhattacharyya, U.C., 1985: On the taxonomy and rarity of gentianella azurea bunge holub. gentianaceae in india. After critical nomenclatural and taxonomic studies Gentianella azurea (Bunge) Holub. is established as a good species. Gentianella angustiflora H. Smith and Gentianella duthiei (Burkill) H. Smith have been reduced to synonyms of Gentianella azurea...

Hoel, J.; Gillet, J.M.; Richer, G.; Legeard, J., 1969: Bilateral uveitis revealing cerebrospinal meningitis. Bulletin des Societes D'ophtalmologie de France 69(3): 407-410

Trimnell, M.R.; Patterson, E.; Fox, T.W.; Bedinger, P.; Albertsen, M.C., 1999: New chromosome 2L male-sterile mutant ms33 and alleles. Three new male-sterile mutations of maize mapping to chromosome 2L were identified independently by 3 research team. On the basis of allelism tests, ms*-6019 is designated as the reference allele for the new male-sterile mutation ms33.

A.V.Z.igailov; E.S.B.baylova; N.S.P.limbetova; D.M.G.aifer; G.G.K.rpova; B.K.I.kakov, 2011: Putative implication of 3?-terminal segment of 18S rRNA in translation initiation of uncapped mRNAs in plants. A putative implication 3?-terminal 18S rRNA segment in the cap-independent initiation of translation on plant ribosomes was studied. It was shown that 3?-terminal segment (nucleotides 1777 1811) of 18S rRNA including the last hairpin 45 was access...

Kaplan, S.A.; Reis, R.B.; Kohn, I.J.; Shabsigh, R.; Te, A.E., 1998: Combination therapy using oral alpha-blockers and intracavernosal injection in men and erectile dysfunction. Objectives. Intracavernosal injection with a combination of agents (ie, phentolamine plus papaverine or alprostadil) has been used in an effort to increase efficacy and reduce side effects compared with single agents. The purpose of this pilot stu...

Fairbrother, H.; Curtis, P.; Goyder, E., 2012: Children's understanding of family financial resources and their impact on eating healthily. Socioeconomic inequalities in childhood are linked to childhood and adult health inequalities. They are particularly closely associated with inequalities in nutritional and consequently health status. Recent research links this to the high cost of...