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Mechanisms of physical activity limitation in chronic lung diseases

, : Mechanisms of physical activity limitation in chronic lung diseases. Pulmonary Medicine 2012: 634761-634761

In chronic lung diseases physical activity limitation is multifactorial involving respiratory, hemodynamic, and peripheral muscle abnormalities. The mechanisms of limitation discussed in this paper relate to (i) the imbalance between ventilatory capacity and demand, (ii) the imbalance between energy demand and supply to working respiratory and peripheral muscles, and (iii) the factors that induce peripheral muscle dysfunction. In practice, intolerable exertional symptoms (i.e., dyspnea) and/or leg discomfort are the main symptoms that limit physical performance in patients with chronic lung diseases. Furthermore, the reduced capacity for physical work and the adoption of a sedentary lifestyle, in an attempt to avoid breathlessness upon physical exertion, cause profound muscle deconditioning which in turn leads to disability and loss of functional independence. Accordingly, physical inactivity is an important component of worsening the patients' quality of life and contributes importantly to poor prognosis. Identifying the factors which prevent a patient with lung disease to easily carry out activities of daily living provides a unique as well as important perspective for the choice of the appropriate therapeutic strategy.


PMID: 23365738

DOI: 10.1155/2012/634761

Other references

Tucca, F.; Moya, H.; Barra, R., 2015: Ethylene vinyl acetate polymer as a tool for passive sampling monitoring of hydrophobic chemicals in the salmon farm industry. Current monitoring programs are focused on hydrophobic chemicals detection in aquatic systems, which require the collection of high volumes of water samples at a given time. The present study documents the preliminary use of the polymer ethylene v...

Seitz, A.E.; Adjemian, J.; Steiner, C.A.; Prevots, D.Rebecca., 2016: Spatial epidemiology of blastomycosis hospitalizations: detecting clusters and identifying environmental risk factors. Blastomycosis is a disease caused by endemic fungi that ranges from severe pulmonary or disseminated to mild or asymptomatic. Environmental factors associated with it are not well described throughout the endemic area. We used the intramural State...

Tewari, M.; Reddy, P.J.; Reddy, C.D.; Newton, R.C.; Taub, R.; Tuncay, O.C.; Tewari, D.S., 1996: Dexamethasone inhibits the IL-1 induced gingival collagenase gene expression. Molecular Biology of the Cell 7(SUPPL ): 238A

Sawinsky, A.; Pásztor, G., 1980: Effect of lead on connective tissue. Zeitschrift für die Gesamte Hygiene und Ihre Grenzgebiete 26(9): 639-641

Walker, E., 2000: Assessing the implementation of workplace health programs outside of controlled environments. The study explored the implementation of workplace health programmes in 14 NHS Trusts (hospitals). It sought to identify different approaches to implementation and measures that could be used to guide future development. The study comprised inter-...

Kamentsev I.Ye, 1968: Determination of Al-Si ordering in potassium feldspar. X-ray diffraction studies.

Nagase, Hiroshi, 1997: Rational design and synthesis of non-peptide kappa opioid agonist. Japanese Journal of Pharmacology 73(SUPPL 1): 40P

Syrett, P.J., 1951: The effect of cyanide on the respiration and the oxidative assimilation of glucose by Chlorella vulgaris. Low concns. of cyanide stimulate the endogenous respiration of C. vulgaris. When glucose is added the respiration rate is increased 4-5-fold but it is then reversibly inhibited by cyanide. 40-70% of the exogenous respiration is inhibited by 0.22 x...

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Paul Charles K., 1972: Photogrammetric Mapping of Mars Landing Sites. Eos, Transactions, American Geophysical Union 53(4): 347