+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Cerium oxide nanoparticles accelerate the decay of peroxynitrite (ONOO(-))

, : Cerium oxide nanoparticles accelerate the decay of peroxynitrite (ONOO(-)). Drug Delivery and Translational Research 3(4): 375-379

Cerium oxide nanoparticles (CeO2 NPs) have been shown to possess a substantial oxygen storage capacity via the interchangeable surface reduction and oxidation of cerium atoms, cycling between the Ce4+ and Ce3+ redox states. It has been well established in many studies that depending on their reactivity and surface chemistry, CeO2 NPs can effectively convert both reactive oxygen species (superoxide, O2 ?, and hydrogen peroxide) into more inert species and scavenge reactive nitrogen species (RNS)(nitric oxide, NO), both in vitro and in vivo. Since much of damage attributed to NO and O2 ? is actually the result of oxidation or nitration by peroxynitrite or its breakdown products and due to the multiple species that these nanoparticles target in vivo, it was logical to test their interaction with the highly reactive molecule peroxynitrite (ONOO?). Here, we report that CeO2 NPs significantly accelerated the decay of ONOO? by three independent methods. Additionally, our data suggest the ability of CeO2 NPs to interact with ONOO? is independent of the Ce3+/Ce4+ ratio on the surface of the CeO2 NPs. The accelerated decay was not observed when reactions were carried out in an inert gas (argon), suggesting strongly that the decay of peroxynitrite is being accelerated due to a reaction of CeNPs with the carbonate radical anion. These results suggest that one of the protective effects of CeO2 NPs during RNS is likely due to reduction in peroxynitrite or its reactive breakdown products.


PMID: 23936755

DOI: 10.1007/s13346-013-0136-0

Other references

Belousov I.A.; Goryshin N.I., 1982: Functional autonomy of elementary reactions in 2 stage photoperiodic reactions of the beetle agonum assimile coleoptera carabidae. Two elementary succeeding reactions (the 2-step short day.sbd.long day photoperiodic reaction (PhPR)) in the beetle, A. assimile, were autonomous. Their main parameters, critical photoperiod and critical duration of the photoperiodic induction, de...

Hancock P.J.; Kelly G.J.; Muka R.; Hagabula M.E., 2000: Managing environmental hazards on a remote oil flowline. Proceedings of the

Murray, E.M.; Bolton, S.K.; Berg, T.; Saporito, R.A., 2016: Arthropod predation in a dendrobatid poison frog: does frog life stage matter?. Frogs in the family Dendrobatidae are well known for their conspicuous colors and variable alkaloid-based chemical defenses. The aposematic coloration in dendrobatid frogs appears to deter predators with color vision, but relatively little is know...

Mohrig W.; Messner B., 1968: Enz lysozyme anti infect as an anti bacterial agent in honey anti infect and bees venom anti infect gram positive bacteria. Acta Biologica et Medica Germanica 21(1): 85-95

SenGupta Supriya, 1965: On the use of the term 'amplitude' in ripple mark description. The vertical distance from crest to trough of a ripple is commonly referred to as 'amplitude' by geologists but this term has long been used in physics with a different connotation. To avoid confusion, it is suggested that geologists use...

Cao, W.J.; Niiya, M.; Zheng, X.W.; Shang, D.Z.; Zheng, X.L., 2008: Inflammatory cytokines inhibit ADAMTS13 synthesis in hepatic stellate cells and endothelial cells. Journal of Thrombosis and Haemostasis 6(7): 1233-1235

Liang, Y.; Peng, H., 2016: STING-cytosolic DNA sensing: the backbone for an effective tumor radiation therapy. Annals of Translational Medicine 4(3): 60-60

Pourrajab, F.; Babaei Zarch, M.; BaghiYazdi, M.; Hekmatimoghaddam, S.; Zare-Khormizi, M.Reza., 2015: MicroRNA-based system in stem cell reprogramming; differentiation/dedifferentiation. Stem cells (SCs) have self-renew ability and give rise to committed progenitors of a single or multiple lineages. Elucidating the genetic circuits that govern SCs to self-renew and to differentiate is essential to understand the roles of SCs and p...

Wang, Z.-juan; Zou, Y., 2012: Observation on therapeutic effects of electroacupuncture at Jiaji Ex-B 2 points plus herbal medicine for herpes zoster. 目的 观察电针夹脊穴配合中药治疗带状疱疹的临床疗效。 方法 将62 例患&...

Muratova, E.N., 2000: B-chromosomes of gymnosperms. The literature on accessory (B) chromosomes of gymnosperm plants is reviewed. Accessory chromosomes are found in around 30 species, representing 4 families (Pinaceae, Taxodiaceae, Cupressaceae and Ephedraceae). Different types of accessory chromos...