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Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia

, : Randomized controlled study of the T-type calcium channel antagonist MK-8998 for the treatment of acute psychosis in patients with schizophrenia. Human Psychopharmacology 28(2): 124-133

This study aimed to evaluate whether the T-type calcium channel antagonist MK-8998 was effective in treating acute psychosis in patients with schizophrenia. This was a randomized, double-blind, parallel-group study. After a placebo lead-in, acutely psychotic inpatients with schizophrenia were randomized to 4?weeks of MK-8998 12/16?mg daily (N?=?86), olanzapine 10/15?mg daily (N?=?47), or placebo (N?=?83). The primary efficacy measure was score on the Positive and Negative Syndrome Scale (PANSS). Out of 216 randomized patients, 158 completed the 4-week study: MK-8998?=?58 (67.4%), olanzapine?=?38 (80.9%), and placebo?=?62 (74.7%). The mean changes from baseline in PANSS score at week 4 for MK-8998 and olanzapine were not significantly different from placebo: MK-8998 placebo difference?=??0.6 [95% confidence interval (CI): ?7.0, 5.8], p?=?0.9; olanzapine placebo difference?=??4.3 [95% CI: ?11.7, 3.1), p?=?0.3. A responder rate analysis (?20% improvement from baseline in PANSS score) suggested an advantage of olanzapine over placebo (odds ratio?=?2.20 [95% CI: 0.95, 5.09], p?=?0.07) but no effect of MK-8998 over placebo (odds ratio?=?1.28 [95% CI: 0.62, 2.64], p?=?0.5). Treatments were generally well tolerated, but more patients reported adverse events for MK-8998 (47.7%) and olanzapine (48.9%) than placebo (37.3%). MK-8998 was not effective in treating acutely psychotic inpatients with schizophrenia, as measured by PANSS score at week 4. Because of the limited efficacy of the active comparator, we cannot exclude the possibility that T-type calcium channel antagonists could prove to be effective in schizophrenia.


PMID: 23532746

DOI: 10.1002/hup.2289

Other references

Cao, M-bo.; Dong, L.; Lu, X-lan.; Luo, J-yan., 2008: An experimental study on the expression and pathogenic effects of cyclooxygenase-2 in nonalcoholic fatty liver disease. Zhonghua Gan Zang Bing Za Zhi 16(4): 315-316

Aïdoudi, S.; Lebeurier, I.; Amiral, J.; Quentin, G.; Caen, J.P.; Han, Z.C., 1998: A 13-24 C-terminal peptide related to PF4 accelerates hematopoietic recovery of progenitor cells in vivo in mice treated with 5-fluorouracil. We have recently reported that platelet factor 4 (PF4), a megakaryocyte-platelet protein, is a potent inhibitor of human and murine megakaryocytopoiesis. In addition, PF4 accelerated the recovery of the marrow precursor cells in 5-fluorouracil (5-...

Gusenleitner, J., 2006: Zwei neue Faltenwespen aus Mauretanien (Hymenoptera: Vespidae: Eumeninae). New species are described: Cyrtolabulus mauretanicus nova spec. [female] and Xanthodynerus lucidus nova spec. [female].

Friese-Hamim, M.; Bladt, F.; Locatelli, G.; Stammberger, U.; Blaukat, A., 2017: The selective c-Met inhibitor tepotinib can overcome epidermal growth factor receptor inhibitor resistance mediated by aberrant c-Met activation in NSCLC models. Non-small cell lung cancer (NSCLC) sensitive to first-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) often acquires resistance through secondary EGFR mutations, including the T790M mutation, aberrant c-Met rec...

Taikang Ning; Blaise, J.Harry.; Avagyan, M.; Dahal, P., 2017: Developmental differences of dimension complexity of hippocampal EEG during REM sleep. This paper uses spectral analysis and correlation dimension index to examine the developmental differences between the EEG measured from two hippocampal subfields, CA1 and the dentate gyrus. The study was focused on the hippocampal EEG during the...

Calvori, C.; Frontali, L.; Leoni, L.; Tecce, G., 1965: Effect of rifamycin on protein synthesis. Nature 207(995): 417-418

Anonymous, 1981: From the LMC Conference: Maternity medical services. British Medical Journal 283(6283): 81-82

Combes, J.; Mellor, T.K., 2008: Treatment of chronic lip fissures with carbon dioxide laser. Resurfacing of cutaneous tissue with carbon dioxide laser increases the amount and quality of collagen and elastin subepithelially. We used this technique to ablate 12 chronic lip fissures in one woman and 10 men. Five patients' fissures had...

Waxman F.; Maurer P.H.; Baram P., 1976: Macrophage inhibitory factor production by nonresponder mice sensitized with glutamic acid alanine tyrosine ter polymer. Federation Proceedings 35(3): 713

Doolittle, B.R.; Windish, D.M., 2015: Correlation of burnout syndrome with specific coping strategies, behaviors, and spiritual attitudes among interns at Yale University, New Haven, USA. This study aimed to determine the correlation of burnout syndrome with specific coping strategies, behaviors, and spiritual attitudes among interns in internal medicine, primary care, and internal medicine/pediatrics residency programs at two inst...