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Assessing the use of haemostatic sealants in tubeless percutaneous renal access and their effect on renal drainage and histology: an experimental porcine study


, : Assessing the use of haemostatic sealants in tubeless percutaneous renal access and their effect on renal drainage and histology: an experimental porcine study. Bju International 112(2): E114-E121

To evaluate the mid-term effects of haemostatic sealant application during tubeless percutaneous nephrolithotomy (PCNL) on renal drainage and histology in an in vivo porcine study.Bilateral percutaneous access was established in 28 porcine renal units. At the end of the procedure, a type 1 absorbable fish origin collagen powder, a human fibrinogen- and thrombin-coated sponge or a cross-linked gelatin granule/topical thrombin matrix were randomly placed on the nephrostomy tracts. Four nephrostomy accesses were left intact and served as controls. No percutaneous tube, ureteric stent or bladder catheter was left in place postoperatively.Computed tomography urography on postoperative days 1, 15, 30 and 40 was used to access renal drainage.On postoperative day 40, all animals were killed and both kidneys from each animal were harvested for histological evaluation. Evidence of risk for drainage occlusion after sealant application was found.The use of haemostatic sealants was associated with significant histological lesions in the renal parenchyma, regardless of which sealant was used.No sealant was identified as superior to the others.Nephrostomy tracts that were left without sealant application (control group) were associated with no morbidity and fewer histopathological changes. Based on these experimental results, the safety of the application of haemostatic sealants in tubeless PCNL should be reassessed, focusing not only on the potential of such materials to occlude urinary drainage but also on their effect on renal histology.Further investigation is considered necessary.

US$19.90

PMID: 23551745

DOI: 10.1111/bju.12060


Other references

Woods, D.D.; Trim, A.R., 1942: Studies in the Metabolism of the Strict Anaerobes. 8. The Metabolism of Amino-acids by Cl. welchii. Washed suspensions of Clostridium welchii, strains S.R.9 and S.R.12, obtained from cultures grown on tryptic caseinogen digest (the medium considered most likely to give rise to production of optimal amounts of amino-acid deaminases) attacked only...

Brocher, F., 1922: Observations biologiques sur les Haliplides. Ann lacustre Bruxelles: 7-18

Xie, B.; Zhao, L.; Chen, H.; Jin, B.; Mao, Z.; Yao, Z., 2014: The mitogen-inducible gene-6 is involved in regulation of cellular senescence in normal diploid fibroblasts. InformationThe mitogen-inducible gene-6 (Mig-6) is a non-kinase scaffolding adaptor protein. It has been shown that Mig-6 may play important roles in regulating stress response, maintaining homeostasis and functioning as a tumor suppressor. In thi...

Naber, S.P.; Goldman, M.P.aslee, M.H., 1969: The effect of melatonin on the iodide concentrating mechanism of the thyroid gland in young adult rats. Proceedings of the South Dakota Academy of Sciences, 48: 44-46

Corazza, M.; Mantovani, L.; Trimurti, S.; Virgili, A., 1994: Occupational contact sensitization to ethylenediamine in a nurse. Contact Dermatitis 31(5): 328-329

Gonzalez, A.L.; Conde, C.; Merino, J., 1994: The mechanisms of immunologic tolerance to autoantibodies. Revista Espanola de Reumatologia 21(7): 290-301

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Kusumoto, M.; Kono, M.; Adachi, S.; Yamasaki, K.; Itouji, E.; Sakai, E.; Endo, M.; Nakamura, T.; Kimura, K., 1994: Gadopentetate-dimeglumine-enhanced magnetic resonance imaging for lung nodules. Differentiation of lung cancer and tuberculoma. Investigative Radiology 29 Suppl 2: S255-S256

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