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Detection of mycotoxins in patients with chronic fatigue syndrome

, : Detection of mycotoxins in patients with chronic fatigue syndrome. Toxins 5(4): 605-617

Over the past 20 years, exposure to mycotoxin producing mold has been recognized as a significant health risk. Scientific literature has demonstrated mycotoxins as possible causes of human disease in water-damaged buildings (WDB). This study was conducted to determine if selected mycotoxins could be identified in human urine from patients suffering from chronic fatigue syndrome (CFS). Patients (n = 112) with a prior diagnosis of CFS were evaluated for mold exposure and the presence of mycotoxins in their urine. Urine was tested for aflatoxins (AT), ochratoxin A (OTA) and macrocyclic trichothecenes (MT) using Enzyme Linked Immunosorbent Assays (ELISA). Urine specimens from 104 of 112 patients (93%) were positive for at least one mycotoxin (one in the equivocal range). Almost 30% of the cases had more than one mycotoxin present. OTA was the most prevalent mycotoxin detected (83%) with MT as the next most common (44%). Exposure histories indicated current and/or past exposure to WDB in over 90% of cases. Environmental testing was performed in the WDB from a subset of these patients. This testing revealed the presence of potentially mycotoxin producing mold species and mycotoxins in the environment of the WDB. Prior testing in a healthy control population with no history of exposure to a WDB or moldy environment (n = 55) by the same laboratory, utilizing the same methods, revealed no positive cases at the limits of detection.


PMID: 23580077

DOI: 10.3390/toxins5040605

Other references

Hammerton, M.E., 1995: Management of ocular burns. This article aims to provide a practical, safe and effective approach to the management of ocular burns of any cause. This approach is based on an understanding of the effects of burn injury on ocular tissues and the principles of promoting a retu...

Baron, P.; Campbell, T.L., 1993: Gender differences in the expression of depressive symptoms in middle adolescents: an extension of earlier findings. Subjects in the present study were 153 French Canadian high school students (98 females, 55 males) participating in the second phase of a larger longitudinal study (Baron & Groulx, 1990; Baron, Régimbald, & Groulx, 1991). The purpose of t...

Medzihradszky, K.F., 2008: Characterization of site-specific N-glycosylation. Even if a consensus sequence has been identified for a post- translational modification, the presence of such a sequence motif only indicates the possibility, not the certainty that the modification actually occurs. Proteins can be glycosylated on...

Sawicki B., 1972: C calcitonin forming cells in vertebrates. Przeglad Zoologiczny: 290-300

Solorzano, Alejandro, 1994: A new species of land poisonous snake of the genus Porthidium (Serpentes: Viperidae), del Suroeste de Costa Rica. A new species of terrestrial pitviper, Porthidium volcanicum, is described from low elevations near Buenos Aires, in the Valle del General, southwestern Puntarenas Province, Costa Rica. It is the eighth known member of the hognosed pitviper genus....

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Fibich, C.; Fiedler, F.; Herold, M.; Kegel, T.; Schoeberg, C.; Schmoll, H.J., 1998: Mycophenolate-mofetil , MMF in the treatment of steroid-refractory autoimmune thrombocytopenia and Evans-syndrome. Blood 92(10 SUPPL 1 PART 1-2): 177A, Nov 15

Zettler F.W.; Rhodes B.B., 1975: Calcium oxalate variability in dieffenbachia picta seedlings. Hortscience 10(5): 481-482

Scienza, A.; Villa, P.; Tedesco, G.; Parini, L.; Ettori, C.; Magenes, S.; Gianazza, E., 1994: A chemotaxonomic investigation on Vitis vinifera L. II. Comparison among ssp. sativa traditional cultivars and wild biotypes of ssp. silvestris from various Italian regions. Extensive screening of seed proteins of cultivars and genotypes of Vitis vinifera subspecies sativa and silvestris, from several Italian localities, was carried out. Data on seed proteins (pH range 4.0-5.5) and 7 isoenzymes were recorded. The resu...

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