geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Sorafenib in patients with progressive epithelioid hemangioendothelioma


, : Sorafenib in patients with progressive epithelioid hemangioendothelioma. Cancer 119(14): 2639-2644

There is no standard treatment for progressive epithelioid hemangioendothelioma (EHE). To investigate the significant vascularization of EHE, the activity/toxicity of sorafenib in patients with progressive EHE was explored.In this multicenter, 1-stage, phase 2 trial of sorafenib (800 mg daily), the primary endpoint, which was chosen by default, was the 9-month progression-free rate. All patients had documented progressive disease at the time of study entry. Fifteen patients were enrolled between June 2009 and February 201The median age was 57 years (range, 31-76 years), and the ratio of men to women was 9:6. The performance status was zero in 10 patients and 1 in 5 patients. Twelve patients had metastases, mainly in the lung (12 patients), liver (5 patients), and bone (3 patients). Five patients had received prior chemotherapy (doxorubicin in 5 patients and taxane in 3 patients). The median sorafenib treatment duration was 124 days (range, from 27 to >271 days). Seven patients required dose reductions or transient treatment discontinuation. The 9-month progression-free rate was 30.7% (4 of 13 patients). The 2-month, 4-month, and 6-month progression-free rate was 84.6% (11 of 13 patients), 46.4% (6 of 13 patients), and 38.4% (5 of 13 patients), respectively. Two partial responses were observed that lasted 2 months and 9 months. Further clinical trials exploring sorafenib as treatment of progressive EHE are needed. Cancer 2013;000:000-000.

US$29.90


Other references

Giudici M.D.; Guarino S.M., 1989: Effects of chronic exposure to cadmium or copper on idothea baltica crustacea isopoda. Acute toxicity tests (LT50) of copper or cadmium on the crustacean isopod Idothea baltica demonstrated differences between females, males, and juveniles. Copper appears to be more toxic than cadmium. The effects of chronic exposure to 5 .mu.l-1 an...

Anwar-Mohamed, A.; Elshenawy, O.H.; El-Sherbeni, A.A.; Abdelrady, M.; El-Kadi, A.O.S., 2015: Acute arsenic treatment alters arachidonic acid and its associated metabolite levels in the brain of C57Bl/6 mice. The toxic effects of arsenic on the whole brain, as well as the discrete regions, has been previously reported for mice. We investigated the effects of acute arsenite (As(III)) on brain levels of arachidonic acid (AA) and its associated metabolite...

Ghosh, H.S.; Ceribelli, M.; Matos, I.; Lazarovici, A.; Bussemaker, H.J.; Lasorella, A.; Hiebert, S.W.; Liu, K.; Staudt, L.M.; Reizis, B., 2014: ETO family protein Mtg16 regulates the balance of dendritic cell subsets by repressing Id2. Dendritic cells (DCs) comprise two major subsets, the interferon (IFN)-producing plasmacytoid DCs (pDCs) and antigen-presenting classical DCs (cDCs). The development of pDCs is promoted by E protein transcription factor E2-2, whereas E protein ant...

Carter, R.E.; Woolson, R.F., 2004: Statistical design considerations for pilot studies transitioning therapies from the bench to the bedside. Pilot studies are often used to transition therapies developed using animal models to a clinical setting. Frequently, the focus of such trials is on estimating the safety in terms of the occurrence of certain adverse events. With relatively small...

Fratzke, M.C.; Anderson, T.L.; Perez, J.L.; Shepherd, J.K.; Roitblat, H.L., 1996: Short term memory abilities appear to be disrupted in humans with exposure to methadone. Society for Neuroscience Abstracts 22(1-3): 175

Reed, F.R.Cowper, 1928: Triassic fossils from Brazil. Fossil lamellibranchs were found in 2 horizons in the upper part of s.c. Estrada Nova beds of Rio Claro, Parana. These beds, believed to be Lower Permian, are now considered Upper Triassic, although the lower part of the beds may prove to be Permi...

Sgrignani, J.; Magistrato, A., 2012: Influence of the membrane lipophilic environment on the structure and on the substrate access/egress routes of the human aromatase enzyme. A computational study. Human aromatase (HA), an enzyme located on the membrane of the endoplasmatic reticulum, is of crucial biological importance in the biosynthesis of estrogens. High levels of estrogens are related with important pathologies, conferring to HA a key r...

Martelli, A.M.; Gilmour, R.S.; Falcieri, E.; Manzoli, F.A.; Cocco, L., 1989: Mitogen-stimulated phosphorylation of nuclear proteins in Swiss 3T3 cells: evidence for a protein kinase C requirement. When Swiss 3T3 fibroblasts are treated with a combination of IGF-I2 and bombesin at mitogenic concentrations, in vivo phosphorylation of some nuclear proteins occurs within 45-90 min. Among these proteins, histone H1 and a 0.75 M PCA soluble polyp...

Osorio Ruiz, C.; Ramirez Casali, M.E.; Mora Tapia, A.M.; Vega Petokvic, M., 2000: Plaxiphora mercatoris Leloup, 1936 Polyplacophora Mopaliidae from Easter Island, Chile Plaxiphora mercatoris Leloup, 1936 Polyplacophora Mopaliidae de Isla de Pascua, Chile. A total 588 specimens of Plaxiphora mercatoris were analyzed, in terms of sizes and sex, registering sizes between 6 and 57 mm. P. mercatoris presents separate sexes, with no external sexual differences; no hermaphrodites were observed. The propor...

Marcotte L.; Chapados C.; Kennedy J.C.; Nadeau P.; Pottier R.H.; Van Lier J.E., 1991: Ph dependent spectral properties of phthalocyanines. Photochemistry & Photobiology 53(SUPPL): 80S-81S