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Prognosis of patients with methicillin-resistant Staphylococcus aureus bloodstream infection treated with teicoplanin: a retrospective cohort study investigating effect of teicoplanin minimum inhibitory concentrations


, : Prognosis of patients with methicillin-resistant Staphylococcus aureus bloodstream infection treated with teicoplanin: a retrospective cohort study investigating effect of teicoplanin minimum inhibitory concentrations. Bmc Infectious Diseases 13: 182-182

The present study was designed to investigate whether teicoplanin minimum inhibitory concentrations (MICs) of methicillin-resistant Staphylococcus aureus (MRSA) isolates play a role in the prognosis of patient with teicoplanin-treated MRSA bloodstream infection (BSI). Between 1 January 2006 and 31 December 2009, adult patients with teicoplanin-treated MRSA BSI in two Taiwan medical centers were retrospectively enrolled. Their blood MRSA isolates were submitted for determination of minimum inhibitory concentrations (MICs) to various antibiotics and multi-locus sequence types. All-cause mortalities on Days 14 and 30, as well as clinical response at the end of teicoplanin therapy were treated as endpoints. Two hundred seventy adult patients were enrolled and 210 blood MRSA isolates were available. Independent risk factors for un-favorable outcome at the end of teicoplanin therapy included septic shock (p < 0.0001) and an elevated C-reactive protein level (p = 0.0064). The independent risk factors for all-cause Day 14 mortality (13.0%) included the presence of auto-immune diseases (p = 0.0235), septic shock (p = 0.0253) and thrombocytopenia (p = 0.0018). The independent risk factors for all-cause Day 30 mortality (26.3%) included age (p = 0.0102), septic shock (p < 0.0001) and thrombocytopenia (p = 0.0059). The current study didn't find a significant role for teicoplanin MICs in the prognosis of adult patients with teicoplanin-treated MRSA BSI.

US$19.90

PMID: 23601053

DOI: 10.1186/1471-2334-13-182


Other references

Robbins, K.A.; Keet, C.A., 2015: Intraoperative anaphylaxis likely due to Gelfoam in a pediatric patient undergoing liver biopsy. Annals of Allergy, Asthma & Immunology 114(6): 531-533

Tjio, J.H.n; Levan, A., 1954: Some experiences with acetic orcein in animal chromosomes. An orcein solution is prepared by dissolving 2 g of orcein in 45 cc of boiling glacial acetic acid, cooling, and adding 55 cc distilled water, and filtering. A mixture of 1 part N HC1 and 9 parts of this orcein solution is used. The tissue to be s...

Zschüntzsch, J.; Voss, J.; Creus, K.; Sehmisch, S.; Raju, R.; Dalakas, M.C.; Schmidt, J., 2013: Provision of an explanation for the inefficacy of immunotherapy in sporadic inclusion body myositis: quantitative assessment of inflammation and β-amyloid in the muscle. In sporadic inclusion body myositis (IBM), inflammation and accumulation of β-amyloid-associated molecules cause muscle fiber damage. We undertook this study to determine why intravenous immunoglobulin (IVIG) and prednisone are not effective in s...

Lyul'ko A.V.; Volkova L.N.; Ustimenko A.F., 1980: Congenital ureteral obstruction in children. The clinical course and methods for the diagnosis of congenital obstructive processes in the ureters of 219 children were analyzed. The kidneys of 60 puppies with experimental unilateral hydronephrosis were subject to morpho-functional examination...

Schwaneberg, O.; Steiner, H.; Bolívar, P.Haring.; Jung, N., 2012: Design of an LED-based sensor system to distinguish human skin from workpieces in safety applications. Commercial light curtains use a technique known as muting to differentiate between work pieces and other objects (e.g., human limbs) based on precise model knowledge of the process. At manually fed machinery (e.g., bench saws), such precise models...

Basu, A.; Cline, J.S., 1995: Oncogenic transformation alters cisplatin-induced apoptosis. Proceedings of the American Association for Cancer Research Annual Meeting 36(0): 3

Moiseeva, I.G., 1970: The effect of inbreeding on the quality of fowl eggs. In a 70% inbred strain of Russian Whites, egg fertility and hatchability were 39.6 and 84.4% resp. v 89.3 and 92.05 in outbreds. In inbreds and outbreds resp., the weighted 2-yr averages for various traits were as follows: egg production, 76.6 and...

König, H.; Lenz, M., 1985: High-resolution nuclear magnetic resonance of the petrous bones. Rontgenpraxis; Zeitschrift für Radiologische Technik 38(9): 321-327

Hull, S.B.; Bennett, S., 2007: The pregnant trauma patient: assessment and anesthetic management. International Anesthesiology Clinics 45(3): 1-18

James, DD., 1984: Home range dynamics of wolf packs on winter range of the western Arctic caribou herd. Alaska Department of Fish and Game Final Report, 1-5 Job No. 14.12R