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Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochlea

, : Connexin30-mediated intercellular communication plays an essential role in epithelial repair in the cochlea. Journal of Cell Science 126(Pt 7): 1703-1712

A role for connexin (Cx)30 in epithelial repair following injury was examined in the organ of Corti, the sensory epithelium of the cochlea. In this tissue, lesions caused by loss of the sensory hair cells are closed by the supporting cells that surround each one. Gap junctions in which Cx30 is the predominant connexin are large and numerous between supporting cells. In mice carrying a deletion in the gene (Gjb6) that encodes Cx30, the size and number of gap junction plaques, and the extent of dye transfer, between supporting cells was greatly reduced compared with normal animals. This corresponded with unique peculiarities of the lesion closure events during the progressive hair cell loss that occurs in these animals in comparison with other models of hair cell loss, whether acquired or as a result of a mutation. Only one, rather than all, of the supporting cells that contacted an individual dying hair closed the lesion, indicating disturbance of the co-ordination of cellular responses. The cell shape changes that the supporting cells normally undergo during repair of the organ of Corti did not occur. Also, there was disruption of the migratory activities that normally lead to the replacement of a columnar epithelium with a squamous-like one. These observations demonstrate a role for Cx30 and intercellular communication in regulating repair responses in an epithelial tissue.


PMID: 23424196

DOI: 10.1242/jcs.125476

Other references

Skall-Jensen, J.; Andersen, H.K., 1968: 3 cases of acquired cytomegalic virus infection. Ugeskrift for Laeger 130(44): 1862-1866

Quinkler, M.; Bujalska, I.J.; Tomlinson, J.W.; Smith, D.M.; Stewart, P.M., 2006: Depot-specific prostaglandin synthesis in human adipose tissue: a novel possible mechanism of adipogenesis. Despite the magnitude of the obesity epidemic, the mechanisms that contribute to increases in fat mass and to differences in fat depots are still poorly understood. Prostanoids have been proposed as potent adipogenic hormones, e.g. metabolites of...

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Weale, M., 2009: Economic progress and health improvement. Bmj 339: B4575-B4575

Kinlaw W.B.; Schwartz H.L.; Mariash C.N.; Oppenheimer J.H., 1985: Glucagon reduces rat hepatic messenger rna s 14 in the evening but not in the morning circadian variation in tissue sensitivity to triiodothyronine and glucagon may account for daily rhythm of messenger rna s 14. Clinical Research 33(4): 875A

Bieniasz A.; Drewniak K.; Klimek R., 1967: Clinical studies on deamino oxytocin woman enz amino peptidase intra venous. American Journal of Obstetrics & Gynecology 98(4): 535-539

Suckling, D.; Burnip, G., 1997: Orientation disruption of Ctenopseustis herana. Orientation disruption of C. herana was tested using pheromone traps baited with synthetic lures in small plot trials in apple orchards, using polyethylene rope dispensers (100/0.1-ha plot). Dispensers released either (a) 100% (Z)-5-tetradecenyl a...

Loucopoulos, L., 1960: Thyroid gland diseases and blood circulation. Deutsches Medizinisches Journal 11: 388-393

White, S.R.; Reese, K.; Sato, S.; Kaler, S.G., 1993: Spectrum of EEG findings in Menkes disease. We evaluated electroencephalograms (EEGs) in 10 boys with Menkes disease, ranging in age from 9 days to 27 months. Three of 10 tracings were normal (the newborn, his 27-month-old half-brother with the classic phenotype, and a 27-month-old mildly a...