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Donor specific tolerance induction in organ transplantation via mixed splenocytes chimerism

, : Donor specific tolerance induction in organ transplantation via mixed splenocytes chimerism.

We have previously shown that donor-derived splenocytes can replace recipients bone marrow and induce donor-specific tolerance (DST). We have also shown the usefulness of the chimeric state for the induction of DST. To perform further analysis of mixed splenocytes chimera, especially the role of each T cells in mixed splenocytes chimera, is indispensable issue for its clinical use. A chimeric state has been shown to achieve long-term survival in MHC-mismatched grafts. The donor-derived splenocytes can replace recipients bone marrow and induce DST. The long-term survival of allogeneic skin grafts was achieved without immunosuppressants. We showed the role of each type of T cells in a splenocyte mixed chimera. This review provides a short summary of our original work, adding some supplemental interpretations. Mix chimerism is thus considered an attractive approach for the induction of DST without the use of immunosuppressants. In this manuscript, we summarize some of the findings on mixed splenocyte chimeras and reviewed mixed chimerism in recent organ transplantation.


PMID: 23656242

DOI: 10.1111/cei.12131

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