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Association between IL8 haplotypes and pathogen levels in chronic periodontitis

, : Association between IL8 haplotypes and pathogen levels in chronic periodontitis. European Journal of Clinical Microbiology & Infectious Diseases 32(10): 1333-1340

Chronic periodontitis (CP) is considered to be a multifactorial disease influenced by microbial and genetic factors. The aim of the present study was to investigate whether the genetic susceptibility to CP in individuals with the IL8 ATC/C haplotype is associated with subgingival levels of periodontopathogens. Sixty-five individuals, grouped according to the presence (n?=?28) or absence (n?=?37) of the IL8 haplotype, were evaluated. After clinical periodontal evaluation, each group was subdivided according to the presence (CP) or absence (H) of periodontitis. Four subgingival samples were obtained from CP and two samples per subject from H patients. The levels and proportions of Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola were analyzed using quantitative real-time polymerase chain reaction (q-PCR). No differences were found in the proportion of periodontopathogenic bacteria between groups with the presence or absence of the IL8 haplotype. However, in the CP groups, the levels of periodontopathogens were significantly higher in the individuals without the IL8 haplotype than in the individuals with the IL8 haplotype. These results suggest that periodontal destruction may occur in patients who are considered to be genetically susceptible to CP with a lower microbial challenge because of the presence of the IL8 ATC/C haplotype than in patients without this haplotype.


PMID: 23660697

DOI: 10.1007/s10096-013-1884-y

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Vlado, J., 1970: First veneer and plywoods from poplarwood cultivated in plantations in Slovenia. Topola 14 (77 78) 6-7

Lundquist, G.A., 1969: Experience with protriptyline treatment of depressive states. Nordisk Psykiatrisk Tidsskrift. Nordic Journal of Psychiatry 23(3): 236-253

Czerney, P.; Lehmann, F.; Wenzel, M.; Buschmann, V.; Dietrich, A.; Mohr, G.J., 2001: Tailor-made dyes for fluorescence correlation spectroscopy (FCS). Two new fluorescent labels are presented that are optimized for excitation with He/Ne laser and red diode lasers. Application in FCS and labeling of proteins and oligomers are demonstrated. A strong rise of quantum yield and emission life time upo...

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Wheeland, R.G.; Gilmore, W.A.; Morgan, R.J., 1983: Use of a nonconductive acrylic pressure ring for control of bleeding during minor surgery. Journal of Dermatologic Surgery and Oncology 9(1): 18-19

Kanwisher, N.; Woods, R.; Mazziotta, J.; Iacoboni, M., 1994: PET studies of object recognition. Society for Neuroscience Abstracts 20(1-2): 840

Ebrahimi, M.; Firuzi, O.; Miri, R.; Razzaghi-Asl, N.; Ebadi, A., 2016: Structural Insight into Binding Mode of 9-Hydroxy Aristolochic Acid, Diclofenac and Indomethacin to PLA 2. NlmCategory="UNASSIGNED">Phospholipase A<sub>2</sub> (PLA<sub>2</sub>) catalyzes the hydrolysis of phospholipids into arachidonic acid and lysophospholipids. Arachidonic acid is modified by cyclooxygenases into...

Das, N.D.; Gupta, S.K., 1992: Incidence of pod borers on pigeonpea germplasm lines. The tolerance of different genotypes of pigeon pea to Helicoverpa armigera was investigated in Hyderabad, Andhra Pradesh, India, in 1990.

Quint J., 1985: Desalting of phosphorus 32 labeled oligonucleotides. American Biotechnology Laboratory 3(2): 32-33