+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Myocardial damage following cardiac surgery: comparison between single-dose Celsior cardioplegic solution and cold blood multi-dose cardioplegia

, : Myocardial damage following cardiac surgery: comparison between single-dose Celsior cardioplegic solution and cold blood multi-dose cardioplegia. Perfusion 28(6): 496-503

Myocardial protection during cardiac surgery can be accomplished by different cardioplegic solutions. The aim of this study was to assess myocardial damage after heart valve surgery performed with myocardial protection of a single dose of Celsior cardioplegia or with repeated cold blood cardioplegia. After the stratification of 139 valvular patients by means of matching according to cross-clamp and cardiopulmonary bypass time, 32 patients were retained for comparison (16 patients received Celsior and 16 patients received cold blood cardioplegia). Creatine kinase-MB (CK-MB) and cardiac troponin I (cTnI) release were evaluated until six days after the operation. Pre-operative characteristics were similar in both groups. In the Celsior group, CK-MB and cTnI values were significantly higher from the first up to the sixth post-operative day. Peak cTnI values were 19.4±13.4 and 9.7±7 ng/mL (p=0.01) in the Celsior and the Cold Blood group, respectively. Peak CK-MB values were 79.6±58.8 and 45.9±20.6 U/L (p=0.07) in the Celsior and the Cold Blood group, respectively. Cold blood cardioplegia reduces perioperative myocardial damage compared to the Celsior solution in elective cardiac valve operations.


PMID: 23670806

DOI: 10.1177/0267659113486827

Other references

Bjørklund, R.A., 1991: Reaction time and movement time measured in a key-press and a key-release condition. Reaction time (RT) and movement time (MT) are measured in two conditions, a key-press and a key-release condition. The latter makes a greater demand on perceptual feedback than the former. RT increases in the key-release condition and a fraction o...

Wilson, E.; Robinson, J.; Leboeuf, E.; Leblanc, D., 1985: Methiocarb-herbicide interaction studies. Annual progress report Louisiana Agricultural Experiment Station: 7th) 123-128

Kelton, J.J.; Holmes, S.K.; Pollack, R.H., 1978: Visual acuity for single lines as a function of hue and age. 176 students in grades 2-12 were tested for visual acuity as a function of minimally resolvable red, yellow, green, and blue lines. A 3-way mixed analysis of variance revealed significant differences among the colors, with better acuity for longer...

Rosen J.F.; Haymovits A., 1975: Red cell lead use of the calcium ionophore a 23187 to characterize a rapidly exchangeable compartment. Pediatric Research 9(4): 286

Lohmann, K.; Markwardt, F.; Landmann, H., 1963: On new fibrinolysis inhibitors. At comparable fibrinolysis-inhibition levels, p-aminomethylbenzoic acid and its hydrated form are effective in concentrations one-fifth as great as those of [image] -aminocapronic acid.

Psaty, B.M.; Doggen, C.; Vos, H.L.; Vandenbroucke, J.P.; Rosendaal, F.R., 2000: Association of the alpha-adducin polymorphism with blood pressure and risk of myocardial infarction. Genetic variation in adducin, a protein associated with the inner leaflet of the plasma membrane, may be in part responsible for salt-sensitive hypertension. In the Netherlands, 560 men who survived a myocardial infarction and 646 men who had unde...

Parkman, R., 1986: The application of bone marrow transplantation to the treatment of genetic diseases. Genetic diseases can be treated by transplantation of either normal allogeneic bone marrow or, potentially, autologous bone marrow into which the normal gene has been inserted in vitro (gene therapy). Histocompatible allogeneic bone marrow transpl...

Crosfill, M., 1996: The Highlands and Islands Medical Service: precursor of a state funded medical care system?. The Highlands and Islands of Scotland cover a large area of the country and are sparsely populated. A series of man-made and natural disasters ensured that, early in the nineteenth century, they were also poverty stricken. It was gradually recogni...

Suteeva, T.G., 1968: The comparative characteristics of aerobic Actinomycetaceae of persons healthy in respect to actinomycosis and in actinomycosis of the maxillofacial region and neck. Stomatologiia 47(1): 46-49

Usui, D.; Shimada, S.; Shimojima, K.; Sugawara, M.; Kawasaki, H.; Shigematu, H.; Takahashi, Y.; Inoue, Y.; Imai, K.; Yamamoto, T., 2013: Interstitial duplication of 2q32.1-q33.3 in a patient with epilepsy, developmental delay, and autistic behavior. Duplications of the 2q33 region are rare; to date, only 13 patients have been reported to have this chromosomal abnormality. The reported duplications are of varying size, and the patients shared developmental delay and minor dysmorphic findings....