geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Deoxynivalenol-induced weight loss in the diet-induced obese mouse is reversible and PKR-independent


, : Deoxynivalenol-induced weight loss in the diet-induced obese mouse is reversible and PKR-independent. Toxicology Letters 221(1): 9-14

The trichothecene deoxynivalenol (DON), a potent ribotoxic mycotoxin produced by the cereal blight fungus Fusarium graminearum, commonly contaminates grain-based foods. Oral exposure to DON causes decreased food intake, reduced weight gain and body weight loss in experimental animals - effects that have been linked to dysregulation of hormones responsible for mediating satiety at the central nervous system level. When diet-induced obese (DIO) mice are fed DON, they consume less food, eventually achieving body weights of control diet-fed mice. Here, we extended these findings by characterizing: 1) reversibility of DON-induced body weight loss and anorexia in DIO mice and 2) the role of double-stranded RNA-activated protein kinase (PKR) which has been previously linked to initiation of the ribotoxic stress response. The results demonstrated that DON-induced weight loss was reversible in DIO mice and this effect corresponded to initiation of a robust hyperphagic response. When DIO mice deficient in PKR were exposed to DON, they exhibited weight suppression similar to DIO wild-type fed the toxin, suggesting the toxin's weight effects were not dependent on PKR. Taken together, DON's effects on food consumption and body weight are not permanent and, furthermore, PKR is not an essential signaling molecule for DON's anorectic and weight effects.

US$19.90

PMID: 23707852

DOI: 10.1016/j.toxlet.2013.05.008


Other references

Salvat, B., 1966: Eurydice pulchra Leach 1815, Eurydice affinis, H. J. Hanson,1905 (Isopodes Cirolanidae) taxonomie, ethologie, ecologie, repartition verticale et cycle reproducteur. Actes de la Societe Linneenne de Bordeaux, 103A 1-77

Kowalewsky, A., 1894: Etudes sur le coeur de quelques Orthopteres. Archives de Zoologie Experimentale, 485-490

Sassen, A.; Kennes, F., 1972: Influence of mixing on dilutions obtained with the microtiter technique. Journal of Immunological Methods 1(3): 313-315

Janciauskiene, S.; Wright, H.T., 1999: Inflammation, antichymotrypsin, and lipid metabolism: autogenic etiology of Alzheimer's disease. Alzheimer's disease is a multifactor pathology, some of whose causes have been inferred from genetic studies, primarily of associated early-onset cases. Much evidence implicates the A beta amyloid peptide as a neurotoxic agent, with chronic i...

Belyaeva, G.S., 1992: The modification of central responses to interoceptive signals in experimental neurosis. The EEG arousal response to gastric distension, was studied. Neurotisation reduced the response to interoceptive stimulation. This seems to be due to disturbance of the central analysis of interoceptive stimuli including the disturbance of normal...

Parish, L.Charles.; Witkowski, J.A., 2007: Dermatology 75 years ago. Skinmed 6(3): 105-106

Garty I.; Koren A.; Goshen Y.; Siplovich L., 1985: The complementary role of sequential technetium 99m methylene diphosphonate and gallium 67 citrate scanning in the diagnosis and follow up of neuroblastoma. Fourteen children with histopathologically confirmed neuroblastoma underwent 38 studies using 99mTc-methylene diphosphonate (MDP) and gallium citrate Ga67 whole-body scintigraphy during various stages of the disease. Ten patients (71%) showed 99mT...

Kren, Lou, 1994: Mail-order spuds. American Vegetable Grower 42: 3

Schnack, A.; Rempis, E.; Decker, S.; Braun, V.; Rubaihayo, J.; Busingye, P.; Tumwesigye, N.Mbona.; Harms, G.; Theuring, S., 2016: Prevention of Mother-to-Child Transmission of HIV in Option B+ Era: Uptake and Adherence During Pregnancy in Western Uganda. Since 2012, lifelong antiretroviral therapy for all HIV-positive pregnant women ("Option B+") is recommended by WHO for the prevention of mother-to-child transmission of HIV (PMTCT). Many sub-Saharan African countries have since introduc...

Apter, A.J.; Kinman, J.L.; Bilker, W.B.; Herlim, M.; Margolis, D.J.; Lautenbach, E.; Hennessy, S.; Strom, B.L., 2006: Is there cross-reactivity between penicillins and cephalosporins?. Background: We sought to determine the risk of an allergic reaction to a cephalosporin exposure in those with prior penicillin reactions.Methods: We conducted a retrospective cohort study using the United Kingdom General Practice Research Database...