+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Efficacy and safety of aprepitant in allogeneic hematopoietic stem cell transplantation

, : Efficacy and safety of aprepitant in allogeneic hematopoietic stem cell transplantation. PharmacoTherapy 33(9): 893-901

To evaluate the efficacy and safety of aprepitant added to standard antiemetic regimens used in high-dose chemotherapy for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Retrospective medical record review. Hematology ward of a university hospital in Japan. Of 88 patients treated with high-dose chemotherapy followed by allo-HSCT, 46 received aprepitant and granisetron as antiemetic therapy (between April 1, 2010, and December 31, 2011), and 42 received granisetron alone (between April 1, 2008, and March 31, 2010).InterventionsPatients in both groups received 3 mg of granisetron intravenously 30 minutes before the administration of anticancer drugs. In the aprepitant group, 125 mg of aprepitant was administered orally 60 90 minutes before the administration of the first moderately to highly emetogenic anticancer drug. On the following days, 80 mg of aprepitant was administered orally every morning. The mean administration duration of aprepitant was 3.3 days (range 3 6 days). and Main ResultsThe primary objective was to evaluate the percentage of patients who achieved complete response (CR; no vomiting and none to mild nausea). The CR rate in the aprepitant group was significantly higher than that in the control group (48% vs 24%, p=0.02). Multivariate analysis showed that nonprophylactic use of aprepitant was associated with failure to achieve CR (odds ratio [OR] 2.92; 95% confidence interval 1.13 7.99, p=0.03). The frequency of abdominal pain was lower in the aprepitant group (9% vs 25%, p=0.03). Rates of other frequently observed adverse drug events were similar between groups. There was no significant difference in neutrophil engraftment (median 18 vs 17 days), platelet engraftment (median 32 vs 32 days), the incidence of acute graft-versus-host-disease (63% vs 55%, p=0.52), viral infection (74% vs 67%, p=0.49), or 1-year overall survival (63% vs 62%, p=0.90) between the two groups. The addition of aprepitant to granisetron increases the antiemetic effect without influencing transplantation-related toxicities in allo-HSCT.


PMID: 23712662

DOI: 10.1002/phar.1294

Other references

Feged, A.; Wolovich, C.; Evans, S., 2002: Food sharing in owl monkeys. American Journal of Primatology 57(Supplement 1): 26

Trikilis, N.; Rawlinson, A.; Walsh, T.F., 1999: Periodontal probing depth and subgingival temperature in smokers and non-smokers. The aim of this study was to investigate the difference in subgingival temperature between smokers and non-smokers at different probing depths, and the effect of probing depth on subgingival temperature for smokers and non-smokers. 20 smokers and...

Solano, Jús.Ramírez.; Baños, A.Trejo.; Durán, Álvaro.Miranda.; Quiroz, E.Carvajal.; Irisson, M.Cruz., 2017: DFT study of anisotropy effects on the electronic properties of diamond nanowires with nitrogen-vacancy center. In the development of quantum computing and communications, improvements in materials capable of single photon emission are of great importance. Advances in single photon emission have been achieved experimentally by introducing nitrogen-vacancy (...

Bridges, R.B., 1985: Protective action of thiols on neutrophil function. A reduced chemotactic responsiveness of polymorphonuclear leukocytes (PMN) isolated from peripheral blood of smokers has previously been demonstrated and suggested to be an acute effect of smoking. The purpose of our studies were to determine: if...

Rume, F.Islam.; Antwerpen, M.; Braun, P.; Biswas, P.Kumar.; Yasmin, M.; Grass, G.; Ahsan, C.Rafiqul.; Hanczaruk, M., 2016: Genome Sequence of Bacillus anthracis Strain Tangail-1 from Bangladesh. Soil was collected in July 2013 at a site where a cow infected with anthrax had been the month before. Selective culturing yielded Bacillus anthracis strain Tangail-1. Here, we report the draft genome sequence of this Bacillus anthracis isolate th...

Hudlicky T.; Barbieri G., 1991: A new 2 plus 3 annulation for highly functionalized dihydrofurans via c c bond formation. An unique low-temperature rearrangement of silyl enol ether terminated oxiranes, prepared by the addition of the dienolate anion of ethyl 2-bromo-4-siloxycrotonate to aldehydes, has been implemented for the synthesis of functionalized dihydrofuran...

Geldenhuys, C.J., 1986: Costs and benefits of the Australian blackwood Acacia melanoxylon in South African forestry. A discussion of the conflicting interests which have been caused by the naturalization of A. melanoxylon in open and disturbed ecosystems outside plantations, which have necessitated the use of expensive control methods. The species is, however, u...

Jones, R.R., 1991: Fusobacterium necrophorum sepsis in a six-year-old girl. Missouri Medicine 88(12): 805-806

Jutras, A.; Gernez, A., 1950: Visibility of the bile ducts during examination of the digestive tract; study and definition of the syndrome; presentation of cases. La Presse Medicale 58(21): 357-360

Wullert Ii, J.R.; Lu, Y., 1994: Limits of the capacity and density of holographic storage. Previous research assessing planar holographic storage and cross talk between volume multiplexed holograms is reviewed. Using these results, we derive equations for volume holographic storage density and capacity. These equations permit us to iden...