+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Metabolically re-modeling the drug pipeline

, : Metabolically re-modeling the drug pipeline. Current Opinion in Pharmacology 13(5): 778-785

Costs for drug development have soared, exposing a clear need for new R&D strategies. Systems biology has meanwhile emerged as an attractive vehicle for integrating omics data and other post-genomic technologies into the drug pipeline. One of the emerging areas of computational systems biology is constraint-based modeling (CBM), which uses genome-scale metabolic models (GSMMs) as platforms for integrating and interpreting diverse omics datasets. Here we review current uses of GSMMs in drug discovery, focusing on prediction of novel drug targets and promising lead compounds. We then expand our discussion to prediction of toxicity and selectivity of potential drug targets. We discuss successes as well as limitations of GSMMs in these areas. Finally, we suggest new ways in which GSMMs may contribute to drug discovery, offering our vision of how GSMMs may re-model the drug pipeline in years to come.


PMID: 23731523

DOI: 10.1016/j.coph.2013.05.006

Other references

Itil T.M.; Menon G.N.; Bozak M.; Songar A., 1982: The effects of oxiracetam isf 2522 in patients with organic brain syndrome a double blind controlled study with piracetam. In a double-blind controlled trial, the clinical effects of oxiracetam, a new nootropic compound, were investigated in a group of 60 elderly patients with organic mental disorders (DSM-III [Diagnostic and Statistical Manual of Mental Disorders III...

Purnell, D.M.; Combs, J.W.; Saggers, G.C., 1974: Cell proliferation in mammary epithelium and correlated histochemical fluctuations in mast cells during the estrous cycle. LSH/SsLAK hamsters at defined intervals from ovulation were given injections of [3H]thymidine to measure DNA synthesis in normal mammary epithelial cells and of colchicine to determine mitotic rate in the cells. DNA synthesis in the mammary epithe...

Cappelletti V.; Miodini P.; Brivio M.; D.F.onzo G., 1985: Interactions among small effectors of neoplastic growth. Breast Cancer Research & Treatment 6(2): 179

L.R.ssa, D.J.; Rogers, D.W.O., 2009: Accuracy of Spencer-Attix cavity theory and calculations of fluence correction factors for the air kerma formalism. EGSnrc calculations of ion chamber response and Spencer-Attix (SA) restricted stopping-power ratios are used to test the assumptions of the SA cavity theory and to assess the accuracy of this theory as it applies to the air kerma formalism for 60C...

Duke J.M., 1990: Mineral deposit models. Program with Abstracts - Geological Association of Canada(Mineralogical Association of Canada(Canadian Geophysical Union, Joint Annual Meeting 15: 34

Clark, E., 1987: Research awareness: its importance in practice. Professional Nurse 2(11): 371-373

Makrythanasis, P.; Antonarakis, S.E., 2014: Pathogenic variants in non-protein-coding sequences. There are approximately 3000 human protein-coding genes that have been linked with (near) monogenic disorders. This knowledge reflects the past and present focus on protein-coding genes as the main reservoir of pathogenic variation in the human ge...

Tiidus, P.M.; Lawler, J.M.; Powers, S.K., 2000: Oxidants, antioxidants and exercise Influence on aging process. Medicine & Science in Sports & Exercise 32(5 Suppl ): S297, May

Banister, E.W.; Jackson, R.C.; Cartmel, J., 1968: The potentiating effect of low oxygen tension exposure during training on subsequent cardiovascular performance. Internationale Zeitschrift für Angewandte Physiologie, Einschliesslich Arbeitsphysiologie 26(2): 164-179

Vieira, Ruy Alvaro, 1962: On syphilis in the district of Lower Cunene. This is a long and comprehensive survey of syphilis and other treponematoses, their social, epidemiological and etiological aspects and the roles of climate, race, etc, and possible endemicity of syphilis. The low mentality, promiscuity and ignora...