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A MAOA gene*cocaine severity interaction on impulsivity and neuropsychological measures of orbitofrontal dysfunction: preliminary results


, : A MAOA gene*cocaine severity interaction on impulsivity and neuropsychological measures of orbitofrontal dysfunction: preliminary results. Drug and Alcohol Dependence 133(1): 287-290

Based on previous evidence of a MAOA gene*cocaine use interaction on orbitofrontal cortex volume attrition, we tested whether the MAOA low activity variant and cocaine use severity are interactively associated with impulsivity and behavioral indices of orbitofrontal dysfunction: emotion recognition and decision-making. 72 cocaine dependent individuals and 52 non-drug using controls (including healthy individuals and problem gamblers) were genotyped for the MAOA gene and tested using the UPPS-P Impulsive Behavior Scale, the Iowa Gambling Task and the Ekman's Facial Emotions Recognition Test. To test the main hypothesis, we conducted hierarchical multiple regression analyses including three sets of predictors: (1) age, MAOA genotype and severity of cocaine use, and the interaction between MAOA genotype and severity of cocaine use. UPPS-P, Ekman Test and Iowa Gambling Task's scores were the outcome measures. We computed the statistical significance of the prediction change yielded by each consecutive set, with a priori interest in the MAOA*cocaine severity interaction. We found significant effects of the MAOA gene*cocaine use severity interaction on the emotion recognition scores and the UPPS-P's dimensions of Positive Urgency and Sensation Seeking: Low activity carriers with higher cocaine exposure had poorer emotion recognition and higher Positive Urgency and Sensation Seeking. Cocaine users carrying the MAOA low activity show a greater impact of cocaine use on impulsivity and behavioral measures of orbitofrontal cortex dysfunction.

US$19.90

PMID: 23755928

DOI: 10.1016/j.drugalcdep.2013.04.031


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Verrotti, A.; Agostinelli, S.; Olivieri, C.; Chiarelli, F.; Curatolo, P., 2011: Early-onset pure absence epilepsy: a distinct epileptic syndrome. Early-onset pure absence epilepsy has not yet considered in the International League Against Epilepsy classification, but several reports have supported its existence as a distinct epileptic syndrome primarily manifesting with typical absences in...

Beyer-Boon, M.E.; de Voogt, H.J.; van der Velde, E.A.; Brussee, J.A.; Schaberg, A., 1978: The efficacy of urinary cytology in the detection of urothelial tumours. Sensitivity and specificity of urinary cytology. The sensitivity and specificity of urinary cytology in the detection of urothelial tumours using voided urine and applying simple smear preparation and staining techniques have been assessed. Of the 2704 patients under investigation 207 had urothe...

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Alami, A.; Slaoui, A.; Cheikhaoui, Y.; Fares, M.; Drissi-Kacemi, A.; Belhaj, S.; Maazouzi, W., 1998: Multiple myxoma of the right ventricle with infiltration of the pulmonary infundibulum and arteries. The authors report a case of multiple myxoma of the right ventricle treated surgically. One of the myxomas infiltrated the right ventricular ourflow tract, the main pulmonary artery and its branches. This case underlines the difficulty of radical...

Pitruk, D.L.; Shuntov, V.P.; Kudryashov, V.A., 1998: Vyacheslav Nikolayevich Ivankov. Biologiya Morya (Vladivostok) 24(4): 264-266, July-Aug

Hay, M.P., 2001: ZD-0473 AstraZeneca. ZD-0473 (formerly JM-473 and AMD-473) is a sterically hindered platinum (II) complex designed and synthesized by Johnson Matthey Technology and the Cancer Research Campaign (CRC) and under development as a potential treatment for cisplatin-resista...

Choi YuJin; Chae HeeJeong; Kim EuiYong, 1999: Steady-state oxidation model by horseradish peroxidase for the estimation of the non-inactivation zone in the enzymatic removal of pentachlorophenol. A theoretical model for the rate of oxidation of the wood preservative pentachlorophenol (PCP) catalysed by horseradish peroxidase (HRP), was investigated to account for the influence of hydrogen peroxide (H<sub>2</sub>O<sub>2<...

Payne, J.R.; Brodbelt, D.C.; Luis Fuentes, V., 2016: Blood Pressure Measurements in 780 Apparently Healthy Cats. Mean systolic blood pressure in apparently healthy cats has been reported as approximately 125 mmHg using direct assessment, but there is greater variability in reported values using indirect assessment. Increasing age and the white-coat effect ar...

Awati, P.R.; Deshpande, D.S., 1935: Respiratory movements in Thalassema bombayensis. Proceedings of the Indian Science Congress, 22: 320-321

Kloor, D.; Staab, H.J.; Koempf, J.; Ritter, H., 1992: Genetic variability of the estrogen receptor detected in various xenotransplanted human carcinomas. Fiebig, H H [Editor], Berger, D P [Editor] Contributions to Oncology; Immunodeficient mice in oncology : 180-190