+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3

, : New susceptibility locus for obesity and dyslipidaemia on chromosome 3q22.3. Human Genomics 7: 15-15

The muscle Ras (MRAS) gene resides on chromosome 3q22.3 and encodes a member of the membrane-associated Ras small GTPase proteins, which function as signal transducers in multiple processes including cell growth and differentiation. Its role in cardiovascular disease is not fully understood yet. In a preliminary study in heterozygous familial hypercholesterolaemia, we identified a locus linking the early onset of coronary artery disease (CAD) to chromosome 3q.22 and elected to sequence the MRAS gene using the MegaBACE DNA analysis system. In the present study, we investigated the association of seven single-nucleotide polymorphisms (SNPs) at this locus with CAD and its dyslipidaemia-related risk traits in 4,650 Saudi angiographed individuals using TaqMan assays by the Applied Biosystems real-time Prism 7900HT Sequence Detection System. Among the studied SNPs, rs6782181 (p = 0.017) and rs9818870T (p = 0.009) were associated with CAD following adjustment for sex, age and other confounding risk factors. The rs6782181_GG also conferred risk for obesity (1,764 cases vs. 2,586 controls) [1.16(1.03--1.30); p = 0.017], hypercholesterolaemia (1,686 vs. 2,744) [1.23(1.02--1.47); p = 0.019], hypertriglyceridaemia (1,155 vs. 3,496) [1.29(1.01--1.45); p = 0.043] and low high-density lipoprotein-cholesterol (lHDL-chol) levels (1,935 vs. 2,401) [1.15(1.02--1.30); p = 0.023] after adjustment. Additionally, rs253662_(CT+) [1.16(1.01--1.32); p = 0.030] was associated with lHDL-chol levels. Interestingly, rs253662 (p = 0.014) and rs6782181 (p = 0.019) were protective against acquiring high low-density lipoprotein-cholesterol (hLDL-chol) levels (p = 0.014), while rs1720819 showed similar effects against CAD (p < 0.0001). More importantly, a 7-mer haplotype, ACCTGAC (chi2 = 7.66; p = 0.0056), constructed from the studied SNPs, its 6-mer derivative CCTGAC (chi2 = 6.90; p = 0.0086) and several other shorter derivatives conferred risk for obesity. hLDL-chol was weakly linked to CTAA (chi2 = 3.79; p = 0.052) and CCT (chi2 = 4.32; p = 0.038), while several other haplotypes were protective against both obesity and hLDL-chol level.Our results demonstrate that the genomic locus for the MRAS gene confers risk for CAD, obesity and dyslipidaemia and point to the possible involvement of other genes or regulatory elements at this locus, rather than changes in the M-Ras protein function, in these events.


PMID: 23738802

DOI: 10.1186/1479-7364-7-15

Other references

Dlnter, Z.; Kull, K.-E., 1951: Further studies on botulism in mink. Botulinum toxin Type C caused food poisoning on three mink farms in Sweden during 1949-50. A peroral dose of 0.01 ml. of broth culture of CL botulinum Type C killed mink in three days. Botulinum toxoid Type C gave protection for up to seven months...

Haskey, N.; Gibson, D.L., 2017: An Examination of Diet for the Maintenance of Remission in Inflammatory Bowel Disease. Diet has been speculated to be a factor in the pathogenesis of inflammatory bowel disease and may be an important factor in managing disease symptoms. Patients manipulate their diet in attempt to control symptoms, often leading to the adoption of...

Sellards Elias Howard, 1931: Early Paleozoic seas of the Texas region. Geological Society of America Bulletin 42(1): 197-198

Skagen, S.K.; Knopf, F.L.; Cade, B.S., 1993: Estimation of lipids and lean mass of migrating sandpipers. Estimation of lean mass and lipid levels in birds involves the derivation of predictive equations that relate morphological measurements and, more recently, total body electrical conductivity (TOBEC) indices to known lean and lipid masses. Using c...

Tejima, H.; Karatsu, Y.; Kawashima, M.; Sakai, S.; Honda, T., 1993: Reduction of dioxin emission on start up and shut down at batch-operational MSW incineration plants. Chemosphere 27(1-3): 263-269

Patterson, S.L.; Morozov, A.; Martin, K.C.; Scanlin, H.; Pittenger, C.; Kandel, E.R., 2000: Rapid activation of TrkB receptors and subsequent subcellular redistribution of activated MAPK are associated with some forms of cAMP-mediated long-lasting synaptic potentiation. BDNF has recently been shown to contribute to some late forms of LTP (L-LTP) at the Schaffer collateral-CA1 synapse in hippocampus (Kang et al., 1997; Korte et al., 1998). In addition to transcription and translation, long-lasting synaptic potenti...

Madsen, L.O., 1979: A proposal which hits like a strong head wind. Sygeplejersken 79(7): 22-22

Takano, M., 1987: Experimental studies on healing process of vascularized bone replantations in the mandible. To study the healing process in free vascularized bone grafts, vascularized bone replants noursihed by inferior alveolar vessels and, as controls, nonvascularized bone replants were made in the mandibles of adult dogs. Over a period of days, the f...

Chicago Zoological Society., 1994: 1993 annual report Chicago Zoological Society Brookfield Zoo. Chicago Zoological Society Annual Report, 1993: 1-36

Chin, H.W.; Hazel, J.J.; Kim, T.H.; Webster, J.H., 1980: Oligodendrogliomas. I. A clinical study of cerebral oligodendrogliomas. Fifty-four patients with oligodendroglioma presented in the past 15 years. In contrast to some widely taught concepts, oligodendrogliomas occured largely in the frontotemporal area of both cerebral hemispheres with two peaks of age incidence: one...