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Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox


, : Manganese-exposed developing rats display motor deficits and striatal oxidative stress that are reversed by Trolox. Archives of Toxicology 87(7): 1231-1244

While manganese (Mn) is essential for proper central nervous system (CNS) development, excessive Mn exposure may lead to neurotoxicity. Mn preferentially accumulates in the basal ganglia, and in adults it may cause Parkinson s disease like disorder. Compared to adults, younger individuals accumulate greater Mn levels in the CNS and are more vulnerable to its toxicity. Moreover, the mechanisms mediating developmental Mn-induced neurotoxicity are not completely understood. The present study investigated the developmental neurotoxicity elicited by Mn exposure (5, 10 and 20 mg/kg; i.p.) from postnatal day 8 to PN27 in rats. Neurochemical analyses were carried out on PN29, with a particular focus on striatal alterations in intracellular signaling pathways (MAPKs, Akt and DARPP-32), oxidative stress generation and cell death. Motor alterations were evaluated later in life at 3, 4 or 5 weeks of age. Mn exposure (20 mg/kg) increased p38MAPK and Akt phosphorylation, but decreased DARPP-32-Thr-34 phosphorylation. Mn (10 and 20 mg/kg) increased caspase activity and F2-isoprostane production (a biological marker of lipid peroxidation). Paralleling the changes in striatal biochemical parameters, Mn (20 mg/kg) also caused motor impairment, evidenced by increased falling latency in the rotarod test, decreased distance traveled and motor speed in the open-field test. Notably, the antioxidant Trolox reversed the Mn (20 mg/kg)-dependent augmentation in p38MAPK phosphorylation and reduced the Mn (20 mg/kg)-induced caspase activity and F2-isoprostane production. Trolox also reversed the Mn-induced motor coordination deficits. These findings are the first to show that long-term exposure to Mn during a critical period of neurodevelopment causes motor coordination dysfunction with parallel increment in oxidative stress markers, p38MAPK phosphorylation and caspase activity in the striatum. Moreover, we establish Trolox as a potential neuroprotective agent given its efficacy in reversing the Mn-induced neurodevelopmental effects.

US$19.90

PMID: 23385959

DOI: 10.1007/s00204-013-1017-5


Other references

Tesche, C., 2007: QUANTUM MECHANICS: Enhanced: Schrodinger's Cat Is Out of the Hat. In 1935, Erwin Schrödinger suggested his famous gedanken experiment of the cat that is simultaneously "dead" and "alive" inside its box until the box is opened. But as Tesche explains in her Perspective, such a macroscopic man...

Anonymous, 1998: Insect pest management: Proceedings of Workshop No. 1, 19-20th May 1998, Gatton Research Station, Queensland, Australia. The purpose of the workshop was to exchange information, provide updates of project activities, to facilitate communication about pest management in sweetcorn between project team members, growers and other stakeholders and to plant integrated pro...

Möhrenschlager, M.; Braun-Falco, M.; Ring, J.; Abeck, D., 2003: Fabry disease: recognition and management of cutaneous manifestations. Fabry disease (angiokeratoma corporis diffusum universale) is a rare, X chromosome-linked lysosomal storage disease. The deficient enzyme, alpha-galactosidase A (alpha-gal A), is responsible for the accumulation of neutral glycosphingolipids withi...

Herre, J.M.; Bernstein, R.C.; Klevan, L.R., 1996: Cost-effectiveness of ICD versus tiered strategy. Circulation 94(9): 2321-2322

Mayor, A.; Saute, F.; Aponte, J.J.; Almeda, J.; Gomez Olive, F.X.; Dgedge, M.; Alonso, P.L., 2003: Plasmodium falciparum multiple infections in Mozambique, its relation to other malariological indices and to prospective risk of malaria morbidity. We describe the frequency of Plasmodium falciparum clones infecting individuals living in a rural area of southern Mozambique and analyse the relationship between multiplicity of infection, age and other malariometric indices, including prospectiv...

Lauter, J.L., 1984: Contralateral interference and ear advantages for identification of three-element patterns. Recent experience with attempts to test relatively simple patterns such as three-tone sequences in a traditional dichotic-listening paradigm indicates that when such sequences are used for both target and contralateral interference, performance te...

Lionakis, S.; Chouliaras, V.; Gerasopoulos, D., 1994: Effects of shading on vegetative, reproductive and fruit maturity aspects of 'Hayward' kiwifruit. Kiwifruit vines (cv. Hayward) were grown under 0, 25 or 50% shade for 4 continuous years. Both vegetative growth (canes per vine, fruiting shoots per cane) and crop load gradually decreased with increasing shade. Vine productivity in the fourth ye...

Bussières, Aé., 2012: The JCCA is delighted to announce the recent appointment of Dr. André Bussières DC, PhD candidate to Assistant Editor. Journal of the Canadian Chiropractic Association 56(2): 93-93

Cavallaro, G.; Iorio, O.; Centanni, M.; Porta, N.; Iossa, A.; Gargano, L.; Del Duca, S.; Gurrado, A.; Testini, M.; Petrozza, V.; Silecchia, G., 2016: Parathyroid Reimplantation in Forearm Subcutaneous Tissue During Thyroidectomy: A Simple and Effective Way to Avoid Hypoparathyroidism. Parathyroid autotransplantation plays an important role in preventing hypoparathyroidism following thyroidectomy. The preferred reimplantation site is still the sternocleidomastoid muscle, but this approach does not permit to check graft vitality...

Castlebury, L.A.; Carris, L.M.; Vinky, Kálmán., 2006: Phylogenetic analysis of Tilletia and allied genera in order Tilletiales (Ustilaginomycetes; Exobasidiomycetidae) based on large subunit nuclear rDNA sequences. The order Tilletiales (Ustilaginomycetes, Basidiomycota) includes six genera (Conidiosporomyces, Erratomyces, Ingoldiomyces, Neovossia, Oberwinkleria and Tilletia) and approximately 150 species. All members of Tilletiales infect hosts in the grass...