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Tight junction proteins: from barrier to tumorigenesis

, : Tight junction proteins: from barrier to tumorigenesis. Cancer Letters 337(1): 41-48

The tight junction is a multi-protein complex and is the apical most junctional complex in certain epithelial and endothelial cells. A great deal of attention has been devoted to the understanding of these proteins in contributing to the barrier function that is, regulating the paracellular flux or permeability between adjacent cells. However, tight junction proteins are now recognized as having functions beyond the barrier. The focus of this review is to discuss the barrier function of the tight junction and to summarize the literature with a focus on the role of tight junction proteins in proliferation, transformation, and metastasis.


PMID: 23743355

DOI: 10.1016/j.canlet.2013.05.038

Other references

de Broca, A., 1997: Facing grief. Soins; la Revue de Reference Infirmiere: Xii-Xii

Allen, M.F.;, T.V., 1982: Spore germination and axenic culture of endomycorrhizae. B. Dual culture of endomycorrhizae. Infections in (a) agar or hydroponics, and (b) sand and soil are discussed. A growth medium for VAM in agar culture is given.

Bercovich, Z.; Jong, M.F. de, 1976: Brachygnathia superior as a clinical feature of atrophic rhinitis in eight-week-old piglets. Determining the degree of shortening of the upper jaw is described as an effective and simple method by which piglets with severe atrophic rhinitis may be identified as early as 8 weeks of age. A high positive correlation between shortening of the...

Amin, E.N.; McCann, E.T.; Mieczkowski, B.P., 2013: 24/7 intensivist coverage, macrolides in acute lung injury, and roflumilast. American Journal of Respiratory and Critical Care Medicine 187(4): 446-447

Sucoff, E., 1969: Freezing of conifer xylem and the cohesion-tension theory. In a study of the apparent contradiction between the cohesion-tension theory and the lack of air blockage after freezing in conifers, 5- to 10-cm. lengths of the main stem of actively transpiring Thuja occidentalis, Picea glauca and Pinus sylvestr...

Solis, I.; Winkler, O., 1992: International reports continued: Mexico-Israel. Jojoba happenings 20(5): 1

Johnson, B.L.; Hall, O., 1966: Electrophoretic studies of species relationships in Triticum. Homology between protein electrophoresis bands of different species based on similarities in migration velocity provides criteria of genetic affinity from which evolutionary relationships may be inferred. Protein homologies confirm the involvement...

Green, M.H.L.; Arlett, C.F.; Bentham, G.; Cortopassi, G.; Liu, Y.; Steingrimsdottir, H.; Capulas, E.; Cole, J., 1997: Hprt mutation in human T-lymphocytes may be linked to sun exposure and to Bcl-2 translocation. British Journal of Dermatology 136(3): 454

Znaniecka, G.; Bobrowska, W.; Pelc, I., 1979: Effect of contents of calcium and phosphorus in the diet on retention of nitrogen and energy in growing geese. Four groups of 24 White Italian goslings were fed from 1 day old for 4 weeks on a complete feed with plant protein only and with calcium, total phosphorus and inorganic P at 0.74, 0.82 and 0.31; 0.82, 0.91 and 0.41; 1.14, 1.10 and 0.54; and 1.38,...

Spiechowicz, E.; Budkiewicz, A., 1977: Removable prosthetic appliances for treatment of malocclusion. Protetyka Stomatologiczna 27(1): 17-25