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Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection


, : Interleukin 1 enhances vaccine-induced antifungal T-helper 17 cells and resistance against Blastomyces dermatitidis infection. Journal of Infectious Diseases 208(7): 1175-1182

Vaccine-induced T-helper 17 (Th17) cells are necessary and sufficient to protect against fungal infection. Although live fungal vaccines are efficient in driving protective Th17 responses and immunity, attenuated fungi may not be safe for human use. Heat-inactivated formulations and subunit vaccines are safer but less potent and require adjuvant to increase their efficacy. Here, we show that interleukin 1 (IL-1) enhances the capacity of weak vaccines to induce protection against lethal Blastomyces dermatitidis infection in mice and is far more effective than lipopolysaccharide. While IL-1 enhanced expansion and differentiation of fungus-specific T cells by direct action on those cells, cooperation with non-T cells expressing IL-1R1 was necessary to maximize protection. Mechanistically, IL-17 receptor signaling was required for the enhanced protection induced by IL-Thus, IL-1 enhances the efficacy of safe but inefficient vaccines against systemic fungal infection in part by increasing the expansion of CD4+ T cells, allowing their entry into the lungs, and inducing their differentiation to protective Th17 cells.

US$19.90

PMID: 23788728

DOI: 10.1093/infdis/jit283


Other references

Albi, J.L.; Canals, P.; Gallardo, M.A.; Sanchez, J., 1994: Na+-independent L-alanine uptake by trout cells: Evidence for the existence of at least two functionally different asc systems. The Na+-independent uptake of L-alanine has been studied in trout red blood cells, isolated hepatocytes and peripheral blood lymphocytes. The present study shows the existence of two functionally different Na+-independent systems for short chain n...

Mastropietro, F.; Modiano, G.; Cappabianca, M.; Foglietta, E.; D'Asero, C.; Mezzabotta, M.; Ponzini, D.; Maffei, L.; Amato, A.; Lerone, M.; Grisanti, P.; D.B.agio, P.; Rinaldi, S.; Bianco, I., 2002: Factors regulating Hb F synthesis in thalassemic diseases. BACKGROUND: The thalassemic syndromes originate from mutations of the globin genes that cause, besides the characteristic clinical picture, also an increased Hb F amount. It is not yet clear if there are more factors, besides the beta globin genot...

Seikaly, H.; Cuyler, J.P., 1994: Infantile subglottic hemangioma. Infantile subglottic hemangiomas are rare congenital lesions of the larynx that are difficult to manage. Our experience with 10 cases was reviewed. All patients presented with stridor at birth, or shortly after. The minimum follow-up was 6 months,...

Deshayes, Sébastien.; Morris, M.C.; Divita, G.; Heitz, Fédéric., 2006: Interactions of amphipathic carrier peptides with membrane components in relation with their ability to deliver therapeutics. To identify rules for the design of efficient CPPs that can deliver therapeutic agents such as nucleic acids (DNAs, siRNAs) or proteins and PNAs into subcellular compartments, we compared the properties of several primary and secondary amphipathi...

Wilson, J.F., 1959: Density, Defender and Janus: three new wilt-tolerant hops. Notes on three new wilt-tolerant hops. Detailed morphological descriptions are given of these 3 new wilt-tolerant varieties now released to hop growers. Their behaviour in brewing trials over several seasons is summarized . Density (formerly D1) is a late hop of vigourous habit and hig...

Hresko, M.Timothy.; Talwalkar, V.; Schwend, R., 2016: Early Detection of Idiopathic Scoliosis in Adolescents. Journal of Bone and Joint Surgery. American Volume 98(16): E67-E67

Cran, D.G.; Dott, H.M., 1976: The ultrastructure of knobbed bull spermatozoa. A defect of the sperm acrosome, called knobbing has been associated with sterility in the bull and other mammals. It is apparently an autosomal sex-linked recessive characteristic in Friesian bulls. Semen was collected in an artificial vagina from...

Martin, C.K.; Dirksen, W.P.; Carlton, M.M.; Lanigan, L.G.; Pillai, S.P.; Werbeck, J.L.; Simmons, J.K.; Hildreth, B.E.; London, C.A.; Toribio, R.E.; Rosol, T.J., 2016: Combined zoledronic acid and meloxicam reduced bone loss and tumour growth in an orthotopic mouse model of bone-invasive oral squamous cell carcinoma. Oral squamous cell carcinoma (OSCC) is common in cats and humans and invades oral bone. We hypothesized that the cyclooxygenase (COX)-2 inhibitor, meloxicam, with the bisphosphonate, zoledronic acid (ZOL), would inhibit tumour growth, osteolysis a...

Crombé, A.; Saranathan, M.; Ruet, A.; Durieux, M.; de Roquefeuil, E.; Ouallet, J.C.; Brochet, B.; Dousset, V.; Tourdias, T., 2015: MS lesions are better detected with 3D T1 gradient-echo than with 2D T1 spin-echo gadolinium-enhanced imaging at 3T. In multiple sclerosis, gadolinium enhancement is used to classify lesions as active. Regarding the need for a standardized and accurate method for detection of multiple sclerosis activity, we compared 2D-spin-echo with 3D-gradient-echo T1WI for th...

Rossmann, M.G.; He, Y.; Kuhn, R.J., 2002: Picornavirus-receptor interactions. Many picornaviruses use cell-surface molecules belonging to the immunoglobulin superfamily (IgSF) as their cellular receptors. These molecules usually consist of tandem repeats of between two and five Ig-like domains whose amino-terminal domains (...