+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Impaired quality of life, disability and mental health in Takayasu's arteritis

, : Impaired quality of life, disability and mental health in Takayasu's arteritis. Rheumatology 52(10): 1898-1904

Objective. Patient-reported outcomes (PROs) are increasingly accepted to be among the major tools for outcome assessment in rheumatic disorders. In this study we aimed to assess quality of life (QoL), disability, anxiety and depression in patients with Takayasu’s arteritis (TAK). Methods. Patients followed with the diagnosis of TAK (n = 165) and healthy controls (HCs) (n = 109) were enrolled to the study. The 36-item Short Form Health Survey (SF-36) and hospital anxiety and depression scales (HADS) were used to assess QoL and mental status together with HAQ for disability. In SF-36 subscale assessment, all items were observed to be statistically lower in TAK patients; similarly HAQ scores were also higher (P < 0.001) in this group. In mental assessment, anxiety was found to be more common in TAK patients [90 (54.5%) vs 38 (34.9%), P = 0.001]. Depression also tended to be higher in TAK patients [70 (66.7%) vs 35 (33.3%)], without reaching significance (P = 0.086). Most of the SF-36 subgroup parameters were lower in TAK patients with active disease. Patients having anxiety and depression or with high HAQ scores reported worse SF-36 scores. In multivariate analysis, HADS-A, HADS-D and HAQ were associated with most SF-36 subscales. Conclusion. PROs demonstrate that not only general health but also physical and social functioning with physical role limitations and mental health parameters were impaired in TAK. Our results, especially in active disease, suggest that PROs such as SF-36 can be core domains of disease assessment in TAK, similar to ANCA-associated vasculitides.


PMID: 23873821

DOI: 10.1093/rheumatology/ket238

Other references

Li, X.; Major, C.; Blake, M.S.; Murray, K.; Gomez, P.; Mcneil, P.; Bain, R.M.; Strunic, G.V.; Read, S., 1996: HIV-specific IgA antibodies in vertically exposed babies. ELEVENTH INTERNATIONAL CONFERENCE ON AIDS [Author] Eleventh International Conference on AIDS, Vol Two One world: One hope : 59

Terjesen, T.; Apalset, K., 1988: The influence of different degrees of stiffness of fixation plates on experimental bone healing. In order to throw some light on the controversial issue of the optimal stiffness in fracture fixation, the effects on bone healing of rabbit tibial osteotomies fixed by plates with four different degrees of stiffness were studied. The least stiff...

Ajello L.; Padhye A., 1980: Dermatophytes and the agents of superficial mycoses. Lennette, E H Et Al (Ed ) Manual Of Clinical Microbiology, 3rd Edition Xvii+1044p American Society For Microbiology: Washington, D C , Usa Illus P541-552

Plochinger, B.; Oberhauser, R.; Stradner, H.; Woletz, G., 1964: Die tektonischen Fenster von St. Gilgen und Strobl am Wolfgangsee (Salzburg, Osterreich). Jahrbuch der Geologischen Bundesanstalt Wien, 107: 11-69

Page, B.; Page, M., 1996: Treatment of drug resistant ovarian cancer cells with daunorubicin antibody conjugates. Molecular Biology of the Cell 7(SUPPL ): 77A

Scott, C.Thomas.; Magnus, D., 2015: Wrongful termination: lessons from the Geron clinical trial. Geron Corporation is a publically traded company that launched a phase I clinical trial of a human embryonic stem cell-based therapy for spinal cord injury. The company enrolled the first patient in October 2010 and stopped the trial 1 year later....

Tsomides T.; Eisen H.N., 1990: Molecular characterization of peptide class i mhc protein interaction. FASEB Journal 4(7): A1696

Mirante, J.P.; Christmas, D.A.; Yanagisawa, E., 2007: Endoscopic view of allergic fungal sinusitis. Ear, Nose, & Throat Journal 86(2): 74-74

D.Paolo, E.A., 2014: The worldly constituents of perceptual presence. Frontiers in Psychology 5: 450-450

Voos, W.; Gambill, B.D.; Laloraya, S.; Ang, D.; Craig, E.A.; Pfanner, N., 1994: Mitochondrial GrpE is present in a complex with hsp70 and preproteins in transit across membranes. We characterized a 24-kDa protein associated with matrix hsp70 (mt-hsp70) of Neurospora crassa and Saccharomyces cerevisiae mitochondria. By using specific antibodies, the protein was identified as MGE, a mitochondrial homolog of the prokaryotic h...