+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pleiotropic effects of hexavalent chromium (CrVI) in Mytilus galloprovincialis digestive gland

, : Pleiotropic effects of hexavalent chromium (CrVI) in Mytilus galloprovincialis digestive gland. Chemosphere 83(8): 1087-1095

Hexavalent Chromium Cr(VI) is an important contaminant considered as a model oxidative toxicant released from both domestic and industrial effluents, and represents the predominant chemical form of the metal in aquatic ecosystems. On the other hand, in mammals the reduced form Cr(III) is considered an essential microelement, involved in regulation of lipid and carbohydrate metabolism; moreover, recent evidence suggests that Cr may have endocrine effects. In this work, the effects of Cr(VI) were investigated in the digestive gland of the marine bivalve Mytilus galloprovincialis. Mussels were exposed to 0.1-1-10-100 μg Cr(VI) L(-1) animal(-1) for 96 h. At 100 μg L(-1), a large increase in total Cr tissue content was observed; in these conditions, the lysosomal membranes were completely destabilized, whereas other lysosomal biomarkers (neutral lipids-NL and lipofuscin-LF), as well as different enzyme activities and gene expression were unaffected, this indicating severe stress conditions in the tissue. On the other hand, at lower concentrations, changes in other histochemical, biochemical and molecular endpoints were observed. In particular, at both 1 and 10 μg L(-1), lysosomal destabilization was associated with significant NL and LF accumulation; however, no changes in catalase and GSH transferase (GST) activities were observed. At the same concentrations, GSSG reductase (GSR) activity was significantly increased, this probably reflecting the recycling of GSSG produced in the GSH-mediated intracellular reduction of Cr(VI). Increased activities of the key glycolytic enzymes PFK (phosphofructokinase) and PK (pyruvate kinase) were also observed, indicating that Cr(VI) could affect carbohydrate metabolism. Cr(VI) induced downregulation or no effects on the expression of metallothioneins MT10 and MT20, except for an increase in MT20 transcription in males. Moreover, significant up-regulation of the Mytilus estrogen receptor MeER2 and serotonin receptor (5-HTR) were observed in both sexes. The results demonstrate that exposure to Cr(VI) in the low ppb range did not result in strong toxicity or oxidative stress conditions in mussel digestive gland. On the other hand, our data support the hypothesis that low concentrations of the metal can exert pleiotropic effects on mussel physiology, from modulation of lipid and carbohydrate metabolism, to effects on the expression of estrogen-responsive genes.


PMID: 21316074

DOI: 10.1016/j.chemosphere.2011.01.037

Other references

Liu, W., 1955: Vaginal cornification in women with uterine cancer. This study is an evaluation of vaginal cornification of women in different age groups and a comparison between the patients with cancer of the uterus and their controls. The smears from 100 non-cancerous women in each of the 6 decades from age 20...

Yuan, X.; Tao, Y.; Zhao, J.P.; Liu, X.S.; Xiong, W.N.; Xie, J.G.; Ni, W.; Xu, Y.J.; Liu, H.G., 2016: Long-term efficacy of a rural community-based integrated intervention for prevention and management of chronic obstructive pulmonary disease: a cluster randomized controlled trial in China's rural areas. This study aimed to assess the efficacy of a rural community-based integrated intervention for early prevention and management of chronic obstructive pulmonary disease (COPD) in China. This 18-year cluster-randomized controlled trial encompassing...

Narayan, O.; Kennedy-Stoskopf, S.; Sheffer, D.; Griffin, D.E.; Clements, J.E., 1983: Activation of caprine arthritis-encephalitis virus expression during maturation of monocytes to macrophages. In a goat naturally infected with the lentivirus caprine arthritis-encephalitis virus, monocytes were the only cells in the peripheral blood leukocytes in which virus was detected; virus activation occurred only when these cells matured into macro...

Gyles, C., 2011: Medical science and society. Canadian Veterinary Journal 51(10): 1061-1064

Cui, C.; Bian, G-Bin.; Hou, Z-Guang.; Zhao, J.; Zhou, H., 2017: A Multimodal Framework Based on Integration of Cortical and Muscular Activities for Decoding Human Intentions About Lower Limb Motions. In this study, a multimodal fusion framework based on three different modal biosignals is developed to recognize human intentions related to lower limb multi-joint motions which commonly appear in daily life. Electroencephalogram (EEG), electromyo...

Shakhotin, I.E., 1975: Healthy herd for the farm complexes. Veterinariia: 6-9

Saito, Y.; Kaneko, M.; Kirihara, Y.; Kosaka, Y.; Collins, J.G., 1995: Intrathecal prostaglandin E-1 produces a long-lasting allodynic state. The existence of prostaglandin (PG) receptors in the spinal cord has been demonstrated, but their role in sensory processing is not yet well defined. PGE-1 is widely used clinically as a vasodilator. The present study was designed to investigate t...

Chee, M.S.; Bankier, A.T.; Beck, S.; Bohni, R.; Brown, C.M.; Cerny, R.; Horsnell, T.; Hutchison, C.A.; Kouzarides, T.; Martignetti, J.A., 1990: Analysis of the protein-coding content of the sequence of human cytomegalovirus strain AD169. Current Topics in Microbiology and Immunology 154: 125-169

Mansour, M.M.; Hamam, A.M.; Hegazy, M.A.; Ezzo, O.H., 2000: Effect of dietary energy on the superovulatory response to PMSG treatment, with special reference to embryo quality, metabolic and endocrine response in female goats. Thirty non-lactating Baladi goats were randomly allocated according to their dietary treatments into 3 groups: restricted diet (Group I), flushing diet (Group II) and high fat diet (Group III). The oestrous cycles were synchronized with progestage...

Hong, C.; Lee, H.; Oh, M.; Kang, C-Yuil.; Hong, S.; Park, S-Ho., 2006: CD4+ T cells in the absence of the CD8+ cytotoxic T cells are critical and sufficient for NKT cell-dependent tumor rejection. NKT cells perform crucial roles in tumor surveillance, functioning as regulators of early host response. In this study, we have assessed the effects of NKT activation at the time of tumor Ag immunization, and have evaluated the contributions of CD...