+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Intestinal absorption of 25-hydroxyvitamin D and osteomalacia in primary biliary cirrhosis

, : Intestinal absorption of 25-hydroxyvitamin D and osteomalacia in primary biliary cirrhosis. Lancet 1(8014): 721-724

Bone histology and intestinal absorption of 25-hydroxyvitamin D3 (25-OHD) were investigated in 11 patients with primary biliary cirrhosis (P.B.C.). 4 patients had osteomalacia, and all these had received long-term cholestyramine. Plasma-25-hydroxyvitamin-D (25-OHD) concentrations after an oral dose of 25-OHD3 were significantly lower in the patients with P.B.C. (especially those with osteomalacia) than in normal controls. Serum calcium and urinary calcium excretion were lower, and serum-alkaline-phosphatase higher, in patients with osteomalacia. It is suggested that absorption of 25-OHD undergoing enterohepatic circulation and of dietary vitamin D is reduced in patients with P.B.C. Absorption of 25-OHD is further decreased by cholestyramine and the development of osteomalacia is thus hastened.


PMID: 66519

Other references

Hahm J.S.; Ostrow J.D.; Mukerjee P.; Webster C.C., 1986: Solubility and pk a unconjugated bilirubin in aqueous buffer and bile salt solutions determined by isoextraction from chloroform. Hepatology 6(5): 1185

Pavka, Elizabeth, 1995: Stroke, nutrition, and antioxidants. Journal of Applied Nutrition 47(1-2): 13-23

Mosnárová, A.; Huzuláková, I.; Sochorová, R.; Babál, P., 1989: The mechanism of the effect of sex hormones on the reactivity of vascular smooth muscle. Using the method of isometric contraction, the authors studied the effect of in vivo and in vitro application of sex hormones (estradiol, progesterone, and testosterone) on the reactivity of spiral strips of the thoracic aorta and renal artery of...

Hartmanis M.G.N., 1986: Solubilization of membrane bound and oxygen sensitive enzymes with 2 n cyclohexylaminoethanesulfonic acid. Federation Proceedings 45(6): 1742

Guzel, A.Irfan.; Kuyumcuoglu, U.; Celik, Y., 2012: Comparative effect of lornoxicam and paracetamol in pain relief in endometrial sampling. We conducted a study to compare the analgesic effect of oral lornoxicam and oral paracetamol before endometrial sampling for benign conditions. This prospective, double-blind, randomized study was conducted on sixty women underwent endometrial sam...

Kenna, G., 1979: Post-harvest fungicidal dips for stone fruit. Agnotes Melbourne Dept of Agriculture: 79 (866 79)

Hyman, S.E., 2000: The millennium of mind, brain, and behavior. Psychiatry enters the new millennium poised to answer many of its central questions. Given the complexity of the human brain and its interactions with our world, these questions are among the most difficult ever addressed by human science. How is...

Solov'eva, L.P., 1987: Rapid method of determining the proliferative activity of cells for assessing the radiation pathomorphism of tumors. Meditsinskaia Radiologiia 32(7): 78-80

Zaridze, D.G.; Nekrasova, L.I.; Basieva, T.K., 1992: Risk factors for bladder cancer. Risk factors of bladder cancer development were studied in a population-based case-control epidemiological study performed in Moscow. Relative risk (RR) indexes appeared to be increased in smokers (4.2) and ex-smokers (3.5) with statistically sign...

Desrochers, Andre., 2003: Bridging the gap linking individual bird movement and territory establishment rules with their patterns of distribution in fragmented forests. Unknown