+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Physiological role of yeasts NAD(P)+ and NADP+-linked aldehyde dehydrogenases

, : Physiological role of yeasts NAD(P)+ and NADP+-linked aldehyde dehydrogenases. Revista Espanola de Fisiologia 33(2): 135-142

The activity of NAD+ and NADP+-linked aldehyde dehydrogenases has been investigated in yeast cells grown under different conditions. As occurs in other dehydrogenase reactions the NAD(P)+-linked enzyme was strongly repressed in all hypoxic conditions; nervetheless, the NADP+-linked enzyme was active. The results suggest that the NAD(P)+ aldehyde dehydrogenase is involved in the oxidation of ethanol to acetyl-CoA, and that when the pyruvate dehydrogenase complex is repressed the NADP+-linked aldehyde dehydrogenase is operative as an alternative pathway from pyruvate to acetyl-CoA: pyruvate leads to acetaldehyde leads to acetate leads to acetyl-Coa. In these conditions the supply of NADPH is advantageous to the cellular economy for biosynthetic purposes. Short term adaptation experiments suggest that the regulation of the levels of the aldehyde dehydrogenase-NAD(P)+ takes place by the de novo synthesis of the enzyme.


PMID: 17891

Other references

Yumita N.; Nishigaki R.; Umemura S.; Umemura K., 1987: Nonthermal effect of ultrasound on tumor. Journal of Pharmaceutical Sciences 76(11): S100

Anonymous, 1927: A Soldier Goes Home. American Journal of Public Health 17(9): 933-934

Knauf, F.; Thomson, R.B.; Heneghan, J.F.; Jiang, Z.; Adebamiro, A.; Thomson, C.L.; Barone, C.; Asplin, J.R.; Egan, M.E.; Alper, S.L.; Aronson, P.S., 2016: Loss of Cystic Fibrosis Transmembrane Regulator Impairs Intestinal Oxalate Secretion. NlmCategory="UNASSIGNED">Patients with cystic fibrosis have an increased incidence of hyperoxaluria and calcium oxalate nephrolithiasis. Net intestinal absorption of dietary oxalate results from passive paracellular oxalate absorption...

Li, W.; Yin, H.; Wen, L.; Cui, J.; Wang, D., 2009: (E)-2-(Isonicotinoylhydrazonometh-yl)benzoic acid methanol monosolvate. The title compound, C(14)H(11)N(3)O(3)·CH(4)O, was synthesized by the condensation reaction of isonicotinohydrazide with an equimolar quantity of 2-formyl-benzoic acid in methanol. The hydrazone mol-ecule displays an E configuration about the C=N...

Wang, Z.; Wang, Y.; Zhao, X., 2014: Panaxquin quefolium diolsaponins dose-dependently inhibits the proliferation of vascular smooth muscle cells by downregulating proto-oncogene expression. Panax quinquefolium saponins (PQS) potentially prevent atherosclerosis in vivo. The proliferation of vascular smooth muscle cells (VSMCs) plays an important role in coronary heart disease and restenosis after percutaneous coronary intervention. He...

Tharby, K.T.; Sheridan, R., 1986: Implementing an equal opportunities policy--a matter of good management practice?. Health Services Manpower Review 12(1): 22-23

Yoshioka, K.; Niinuma, H.; Kawazoe, K.; Ehara, S., 2004: Three-dimensional demonstration of the Adamkiewicz artery and its collateral supply with contrast-enhanced magnetic resonance angiography. European Journal of Cardio-Thoracic Surgery 26(2): 440-441

Beltran Garcia Echaniz A., 1989: Smoking technology origin and composition of the smoke. Alimentaria 26(203): 45-49

Hartline, D.K., 2011: The evolutionary origins of glia. The evolutionary origins of glia are lost in time, as soft tissues rarely leave behind fossil footprints, and any molecular footprints they might have been left we have yet to decipher. Nevertheless, because of the growing realization of the impor...

Allen, K.D.; White, D.D.; Walburn, J.N., 1996: Sucrose as an analgesic agent for infants during immunization injections. Objective: To assess the effectiveness of sucrose as an analgesic agent during routine immunization injections for infants (age range, 2 weeks to 18 months). Study Design: Double-blind, randomized control trial. Setting: Ambulatory care clinic of...