geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

The 'intrinsic adjuvanticity' and immunogenicity of trinitrophenylated lipopolysaccharide


, : The 'intrinsic adjuvanticity' and immunogenicity of trinitrophenylated lipopolysaccharide. Immunology 29(5): 825-834

One thymus-independent immunogen, trinitrophenylated lipopolysaccharide (TNP-LPS) has been studied in vivo and in vitro in C3H/He and C3H/HeJ strains of mice. C3H/HeJ mice have been shown to be low responders, and C3H/He mice high responders to this immunogen. This 'low responder' status of C3H/HeJ mice has been demonstrated to be consequent to an intrinsic defect present at least at the level of B cells. It was demonstrated that high responder cells or 'in vivo milieu' could not restore this deficit to C3H/HeJ cells. It is proposed that the adjuvanticity, mitogenicity and polyclonal activating capacity of LPS are all fundamental to its property of acting as a thymus-independent carrier for the TNP determinant. This observation is discussed from the point of view that the T-cell independence for an antigen cannot derive solely from its multivalency but must depend upon the intrinsic adjuvanticity of that molecule.

US$29.90

PMID: 53194


Other references

Tesei, F.; Farneti, G.; Occhiuzzi, L.; Antonelli, P.; Brusori, S.; Rinaldi Ceroni, A., 1996: Detection of deglutition disorders after reconstructive laryngectomy. Clinical and radiological evaluations. Subtotal reconstructive laryngectomy is an appropriate surgical procedure for intralaryngeal squamous cell carcinoma. After this surgery the functions of the larynx are greatly modified. These functions may be retained if at least one cricoarytén...

Lallès, J-Paul., 2014: Luminal ATP: the missing link between intestinal alkaline phosphatase, the gut microbiota, and inflammation?. American Journal of Physiology. Gastrointestinal and Liver Physiology 306(10): G824-G825

Hong, K.; Sherley, J.; Lauffenburger, D.A., 2001: Methylation of episomal plasmids as a barrier to transient gene expression via a synthetic delivery vector. Efficient and sustained transgene expression are desirable features for many envisioned gene therapy applications, yet synthetic vectors tested to date are rarely successful in achieving these properties. Substantial research efforts have focused...

Ishida, N.; Nečas, D.; Masuda, Y.; Murakami, M., 2016: Enantioselective Construction of 3-Hydroxypiperidine Scaffolds by Sequential Action of Light and Rhodium upon N-Allylglyoxylamides. 3-Hydroxypiperidine scaffolds were enantioselectively constructed in an atom-economical way by sequential action of light and rhodium upon N-allylglyoxylamides. In a formal sense, the allylic C-H bond was selectively cleaved and enantioselectively...

Fasco M.J.; Wilson A.C.; Gierthy J.F., 1987: Lewis lung carcinoma llc cell activation of factor x evidence for the participation of host vitamin k dependent proteins and a cellular sulfhydryl group. Federation Proceedings 46(6): 2243

Heijman, C.G.; Holliger, C.; Glaus, M.A.; Schwarzenbach, R.P.; Zeyer, J., 1993: Abiotic reduction of 4-chloronitrobenzene to 4-chloroaniline in a dissimilatory iron-reducing enrichment culture. 4-chloronitrobenzene (4-Cl-NB) was rapidly reduced to 4-chloroaniline with half-lives of minutes in a dissimilatory Fe(III)-reducing enrichment culture. The initial pseudo-first-order rate constants at 25 degrees C ranged from 0.11 to 0.19 per min...

Wiggans, M.G.; Shahtahmassebi, G.; Aroori, S.; Bowles, M.J.; Briggs, C.; Stell, D.A., 2016: The pre-operative rate of growth of colorectal metastases in patients selected for liver resection does not influence post-operative disease-free survival. To assess the potential association between the change in diameter of colorectal liver metastases between pre-operative imaging and liver resection and disease-free survival in patients who do not receive pre-operative liver-directed chemotherapy....

Baker P.F.; Reuter H., 1975: Pergamon studies in the life sciences calcium movement in excitable cells. Pergamon Studies in The Life Sciences Calcium Movement in Excitable Cells 102

Yeung, H.H., 2014: Urgent ophthalmic examination for renal tubular acidosis. Infantile nephropathic cystinosis. Journal of Pediatric Ophthalmology and Strabismus 49(6): 329, 340-329, 340

Waxman, S.; Sriram, V.; Ashitkov, T.V.; Hu, Z.; Medford, D.J.; Boor, P.J.; Demcheva, M.; Vournakis, J.N., 2001: Safety of poly-N-acetylglucosamine in the pericardial space A novel vehicle for local cardiac drug delivery. Circulation 104(17 Supplement): II 729, October 23