geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A case of motor neuron disease with dementia--cerebral blood flow and cerebral oxygen metabolism


, : A case of motor neuron disease with dementia--cerebral blood flow and cerebral oxygen metabolism. Rinsho Shinkeigaku 32(1): 57-61

A 51-year-old man developed muscle weakness of the bilateral upper extremities, and mental changes beginning with personality change. There was no history of mental illness in his family. A neurological examination 1 year after the onset revealed muscle atrophy and fasciculation of his bilateral upper extremities Neuropsychological examination revealed concrete speech, paraphasia, and lack of judgment. Disorientation, amnesia, dyscalculia, and spatial agnosia, however, were not recognized. These neuropsychological findings were compatible with dementia of frontal lobe type. EMG and muscle biopsy revealed neurogenic muscular atrophy. There was no abnormal findings in the brain X-CT and the brain MRI. PET study using C15O2 and 15O2 revealed reduction of cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) in the bilateral medial frontal cortex, the left temporal cortex and the bilateral thalamus. From these these findings the patient was diagnosed as having motor neuron disease with dementia. Muscle atrophy and dementia worsened gradually. A second PET study 2 years and 6 months after the onset revealed severe reduction of CBF and CMRO2 in the bilateral temporal cortex and the thalamus. These PET findings suggested that dysfunction of the temporal cortex and the thalamus related to dementia in this case.

US$29.90

PMID: 1628437


Other references

Liang, C.W.; Mohammadi, M.; Santos, M.Daniel.; Santos, M.Danial.; Tang, C-Min., 2011: Patterned photostimulation with digital micromirror devices to investigate dendritic integration across branch points. Light is a versatile and precise means to control neuronal excitability. The recent introduction of light sensitive effectors such as channel-rhodopsin and caged neurotransmitters have led to interests in developing better means to control pattern...

Dias, A.é Roncon; Nahas, Sérgio Carlos, 2013: A modified supralevator pelvic exenteration for the treatment of locally advanced rectal cancer with vaginal and uterine invasion. Post-chemoradiation T4 rectal cancer remains a therapeutic challenge and an aggressive surgical approach is the only chance for a cure. Rectal lesions infiltrating the upper vaginal wall and uterine cervix are usually treated by low anterior resec...

Anonymous, 1966: Papers presented at a meeting on Land Reclamation held in London on 26 October, 1965. HODGSON, D. R. ; HOLLIDAY, R. The agronomic properties of pulverised fuel ash, p. 785-90, bibl. 8. Tolerance of crop species is shown. HUNTER, F. ; PRINGLE, J. Soil fertility studies on restored opencast coal sites, pp. 790-1, bibl. 6. PIZER, N. H...

Gwinn Vinton E., 1970: The Valley and Ridge and Appalachian Plateau; structure and tectonics; kinematic patterns and estimates of lateral shortening, Valley and Ridge and Great Valley provinces, central Appalachians, south-central Pennsylvania. Undeformed basement, allochthonous Paleozoic sequence.

Plashkevych, O.; Chattopadhyaya, J., 2012: Molecular structure of the core-modified siRNA duplexes containing diastereomeric pair of [C6'(R)-OH]- versus [C6'(S)-OH]-carba-LNAs suggests a model for RNAi action. Molecular structures of native and a pair of modified small interfering RNA-RNA duplexes containing carbocyclic [6 '-(R)-OH/7 '-(S)-methyl]- and [6 '-(S)-OH/7 '-(S)-methyl]-carba-LNA-thymine nucleotides, which are two diast...

Sturm G.; Staehler E.; Daume E., 1975: Steroid sulfation in human ovaries with graafian follicles during in vitro perfusion. Acta Endocrinologica Supplementum 193:

Cassar, J.; McKelvie, P.; Joplin, G.F., 1979: Reversal of laryngeal obstruction following treatment of acromegaly. Journal of Laryngology and Otology 93(4): 403-404

Pappolla, Miguel A., 1999: Use of melatonin to prevent cytotoxic effects of amyloid beta protein. Official Gazette of the United States Patent & Trademark Office Patents 1226(4), Sep 28

McManis, G.L.; Pavia, L.; Ackerman, F.K.; Connelly, I., 1996: Opportunities and issues for medical group practices. For the second consecutive year, McManis Associates, a health care management consulting firm and subsidiary of MMI Companies Inc., held, in conjunction with the 1996 MGMA/AMA joint legislation conference, an executive forum for leaders of medical...

Yamashita, T.; Kuroda, K.; Hirano, W.; Ueno, M.; Yoshizumi, A.; Inomata, Y.; Komine, K., 1996: A nationwide investigation on needs for rehabilitation of schizophrenic outpatients: The patients' attributes and actual conditions of living. In Japan we are very short of community resources for persons with mental disability. The authors, a board of resettlement, thought patients' actual conditions of living and needs for rehabilitation to let them live in the community had to be...