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A double-blind comparative study of the safety, tolerability, and efficacy of ioversol and iohexol in peripheral and visceral arteriography


, : A double-blind comparative study of the safety, tolerability, and efficacy of ioversol and iohexol in peripheral and visceral arteriography. Investigative Radiology 24 Suppl 1: S56-S59

A randomized, double-blind, parallel-group clinical study was conducted to compare the efficacy, tolerability, and safety of ioversol 320 mg I/mL (Optiray, 320 Mallinckrodt Medical, Inc., St. Louis, MO) and iohexol 300 mg I/mL (Omnipaque 300, Winthrop Pharmaceuticals, New York, NY). The study was conducted in 50 patients undergoing peripheral arteriography and in ten patients undergoing visceral arteriography. In the peripheral group, 92% of the radiographs acquired using Optiray were rated excellent or good. Eighty-eight percent of those acquired with Omnipaque were so rated. In the visceral study all radiographs in both groups were rated excellent or good. Patient tolerance was also impressive. We used a four-point rating scale (1 - none; 4 = severe) to score both heat and pain sensations. For peripheral patients the average heat score was 2.4 in the Optiray group versus 2.3 in the Omnipaque group. The average pain scores were 1.1 in both groups. For visceral patients, the average heat scores were 2.4 in both groups, while the pain scores were 1.7 for the Optiray group versus 1.0 for the Omnipaque group. No clinically significant changes in vital signs were observed in any of the patients. One clinically significant change in the electrocardiogram (ECG) tracing was noted after an Optiray injection, but it was not felt to be drug induced. There were five instances in which laboratory values rose from their normal baseline values, but all changes were minor. There was only one adverse reaction in the entire study. A short episode of coughing occurred in one patient who received Omnipaque for a peripheral study; the coughing resolved spontaneously. Both Optiray and Omnipaque proved to be efficacious, well tolerated, and safe for intra-arterial use in peripheral and visceral vessels.

US$29.90

PMID: 2687198


Other references

Sidhu, D.S., 1990: Some aspects of agricultural marketing and pricing policies in India. This paper covers the issues of agricultural marketing, input supplies and pricing policies in India. Marketing efficiency can be improved by increasing (1) operational efficiency and (2) pricing efficiency. A well developed and efficient system o...

Srinivasan, A.; Furuta, H.; Osuka, A., 2002: The first bis-Rh(I) metal complex of N-confused porphyrin. An inner- and outer-N coordinated bis-Rh(I) metal complex was obtained from the reaction of N-confused porphyrin and [Rh(CO)2Cl]2 in CH2Cl2 and the structure was confirmed by a single crystal X-ray analysis.

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Boissevain, Iaira, 2007: Bern cattle dog. Tijdschrift voor Diergeneeskunde 132(11): 445

Hannibal, G.B., 2014: Interpretation of the low-voltage ECG. AACN Advanced Critical Care 25(1): 64-68

Harding, K., 2016: Challenging passivity in venous leg ulcer care - the ABC model of management. NlmCategory="UNASSIGNED">The under-utilisation of compression for venous leg ulcer (VLU) management translates into lost opportunities to heal wounds, improve patients' quality of life and maximise health care system efficiency....

Pontow S.E.; Blum J.S.; Stahl P.D., 1990: Delayed activation of newly synthesized mannose receptor in human macrophages. Journal of Cell Biology 111(5 PART 2): 86A

Meshalkin, L.D.; Galkov, A.F., 1988: Expert statistical methods of constructing algorithms for the prognosis of myocardial infarct. Meditsinskaia Tekhnika: 16-22

Janouch, J., 1989: The results of insemination of cattle in 1988. The percentage of cows plus heifers inseminated in the Czech Republic was 93.7 (+0.7% compared with 1987), and that of heifers was 38.7 (-0.5% compared with 1987). The av. postpartum insemination interval was 66 days, but the percentage of cows wi...

Rule, W.R.; Comer, A.T., 1979: Family constellation and birth order variables related to vocational choice of dentistry. A relatively small amount of research was completed on the family-group variable of birth order and the vocational-group variable of choices in the world of work. Extremely little research has been completed utilizing the socio-psychological persp...