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A model that explains the varying frequency of aneuploid children with maternal age (J-shaped curve) as well as aneuploidy of paternal origin

, : A model that explains the varying frequency of aneuploid children with maternal age (J-shaped curve) as well as aneuploidy of paternal origin. Progress in Clinical and Biological Research 318: 253-257

A compromised microcirculation could account for aneuploidy incidence in women of any reproductive age, the frequency varying with the probability of events leading to reduced development and/or function of the critical perifollicular capillary bed. This would explain the J-shaped curve of changing frequency of Down syndrome children with maternal age (Erickson, 1978). The seminiferous tubule of the testis, like the follicle, has no internal circulation, so small localized regions of reduced circulation could occur and result in aneuploidy. From all that we know about the deficiency of regional microcirculation in tumors (see Hall, 1978), it is reasonable to speculate that reduced pH could be responsible for some of the aneuploidy that is seen in practically all advanced tumors. As a first step in testing the model proposed here, we are beginning studies with mouse oocytes, on the assumption that ovarian conditions are responsible for the maternal age effect rather than uterine conditions (reduced rejection of trisomic fetuses). Should our model for aneuploidy induction in both germ and somatic cells prove to be correct, the molecular mechanism(s) would still have to be ascertained.


PMID: 2696970

Other references

Ohsawa N., 1970: In vivo studies on the mode of action of luteinizing hormone. Folia Endocrinol Jap 46(6): 605

Karlović, D.; Buljan, D.; Martinac, M.; Marcinko, D., 2004: Serum lipid concentrations in Croatian veterans with post-traumatic stress disorder,post-traumatic stress disorder comorbid with major depressive disorder,or major depressive disorder. The aim of this study was to assess eventual differences in serum cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, LDL-C/HDL-C ratio between veterans with combat-related post-tr...

Moreda-Piñeiro, J.; Moreda-Piñeiro, A.; Bermejo-Barrera, P., 2015: In vivo and in vitro testing for selenium and selenium compounds bioavailability assessment in foodstuff. NlmCategory="UNASSIGNED">The assessment of selenium and selenium species bioavailability in foodstuff is of special concern on the context of human nutrition. In vivo (human and animal), and in vitro tests are important approaches for...

Samsonov, M.A.; Poliantseva, L.R.; Kulikov, I.F.; Frolova, I.A.; Tsagikian, T.A., 1978: Change of the enzyme-secretory function of the pancreas in nephrotic syndrome. Klinicheskaia Meditsina 56(3): 117-119

Lacombe, R., 1971: Agricultural motors at the 42nd SIMA. Landtechnik 26 (3) 64

Anonymous, 1975: Public awareness shows growing understanding and support. Texas Dental Journal 93(10): 24-27

Kalimuthu, P.; Abraham John, S., 2008: Optochemical sensing of hydrogen chloride gas using meso-tetramesitylporphyrin deposited glass plate. Meso-tetramesitylporphyrin (MTMP) deposited glass plate (solid state sensor) was used to sense hydrogen chloride (HCl) gas based on optochemical method. Exposure of the solid state sensor to HCl vapor results in the formation of protonated meso-te...

Ahmadian, L.; van Engen-Verheul, M.; Bakhshi-Raiez, F.; Peek, N.; Cornet, R.; de Keizer, N.F., 2011: The role of standardized data and terminological systems in computerized clinical decision support systems: literature review and survey. Clinical decision support systems (CDSSs) should be seamlessly integrated with existing clinical information systems to enable automatic provision of advice at the time and place where decisions are made. It has been suggested that a lack of agree...

Park, C-A.; Kang, C-Ki.; Kim, Y-Bo.; Cho, Z-Hee., 2017: Advances in MR angiography with 7T MRI: From microvascular imaging to functional angiography. Over the past few decades, vascular flow-dependent imaging techniques have proven to be effective for the visualization of large vessel diseases. However, these approaches are unlikely to be efficacious for small vessels because the affected small...

Iwata, T., 1979: Radiation planning of brain tumor. Rinsho Hoshasen. Clinical Radiography 24(13): 1459-1463