geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas


, : A secretory protease inhibitor requires androgens for its expression in male sex accessory tissues but is expressed constitutively in pancreas. Embo Journal 6(12): 3711-3717

A full length cDNA clone encoding a mouse prostatic secretory glycoprotein (p12) whose synthesis is dependent upon testicular androgens has been cloned and characterized. The predicted amino acid sequence of p12 shares extensive homology with several members of the Kazal family of secretory protease inhibitors, in particular the pancreatic secretory trypsin inhibitors. In agreement with sequence data, prostatic secretory p12, purified from mouse ventral prostate secretion, exhibits anti-trypsin activity. Steady-state levels of protease inhibitor mRNA in ventral prostate are reduced from approximately 0.06% in normal mice to undetectable after androgen withdrawal but are inducible within 4 h by re-administration of testosterone. Androgen-dependent expression of the secretory protease inhibitor mRNA was also observed in coagulating gland and seminal vesicle. In seminal vesicle, a tissue of different embryonic origin to the prostate, the kinetics of secretory protease inhibitor mRNA loss after castration are not as rapid as in the ventral prostate and coagulating gland. Low-level androgen independent expression was also observed in the pancreas. There appears to be a single gene for this secretory protease inhibitor and yet expression is markedly stimulated by testosterone in the sex accessory tissues and unaffected by this hormone in the pancreas.

US$29.90

PMID: 3428272


Other references

Hargis, Jr.; W.J., 1956: Monogenetic trematodes of Gulf of Mexico fishes. Part VIII. The superfamily Diclidophoroidea Price, 1936. (Continued). The systematics of Diclidophoroidea are discussed. The diagnosis of Discoco-tylidae is emended and Vallisiinae is consequently transferred to Gastrocptylidae. Tagia is redefined, Kuknia otolithis is placed in this genus as Tagia otolithis (Yamagut...

Dubois Agnes; Odonne Francis; Massonnat Gerard; Lebourg Thomas; Fabre Richard, 2002: Analogue modelling of fault reactivation; tectonic inversion and oblique remobilisation of grabens. Analogue models of sand above a silicone layer were examined to determine the effects of normal fault reactivation. Models were first subjected to extension, which lead to the formation of two linear grabens. Each model was then subjected to a sec...

D.L.charriere, O.; Breton, L., 2001: Alkaline-earth metal salt for the treatment of ocular or palpebral pruritus and dysesthesia. The invention relates to the use of an alkaline-earth metal salt in or for the preparation of a cosmetic or pharmaceutical composition, especially for topical application, for treating ocular or palpebral pruritus and/or ocular or palpebral dysest...

Kruger P.B.; Mathews S.; Fox C.R., 1987: Chromatic cues for accommodation. Investigative Ophthalmology & Visual Science 28(3 SUPPL): 103

Korzun A.G.; Slobodnitskaya G.V.; Mironovich N.A., 1988: Determination of potassium content in plants with the use of an ion selective electrode. Agrokhimiya (2): 96-99

Zsigmond, E.K.; Flynn, K., 1988: The effect of methotrimeprazine on arterial blood gases in human volunteers. Since methotrimeprazine proved to be both an effective tranquilizer and analgesic, its effect in a tranquilizing dose of 0.15 mg/kg on the arterial blood gases was determined in human volunteers. Because of the known potentiating effect of some ph...

Anonymous, 2016: Correction. Annals of Emergency Medicine 67(5): 676-676

Vitha; Dallas; Carr, 1997: A Comparison of Water-Sodium Dodecyl Sulfate Phase Transfer Linear Solvation Energy Relationships and Databases. Four linear solvation energy relationship (LSER) studies of solute partitioning in aqueous sodium dodecyl sulfate micellar solutions are compared. Two of the LSERs are based on compilations of literature data obtained from a variety of measurement...

Bonaccio, M.; Di Castelnuovo, A.; Costanzo, S.; de Curtis, A.; Persichillo, M.; Cerletti, C.; Donati, M.Benedetta.; de Gaetano, G.; Iacoviello, L., 2017: Mean platelet volume is associated with lower risk of overall and non-vascular mortality in a general population. Results from the Moli-sani study. Larger mean platelet volume (MPV) has been associated with adverse health outcomes in high-risk populations or patients with cardiovascular disease (CVD). We tested the association of MPV with mortality in a prospective cohort study including 17,4...

Farcy, H. de, 1973: The marketing principle and agricultural co-operation. The means for organizing marketing strategy more efficiently were discussed at a study seminar at Toulouse, The main ideas put forward by the participants, and conclusions reached by the meeting are examined. Much of the discussion centred on the...