+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

A40926, a new glycopeptide antibiotic with anti-Neisseria activity

, : A40926, a new glycopeptide antibiotic with anti-Neisseria activity. Antimicrobial Agents and ChemoTherapy 31(12): 1961-1966

In the course of a search for glycopeptide antibiotics having novel biological properties, we isolated A40926. Produced by an actinomycete of the genus Actinomadura, A40926 is a complex of four main factors which contain a fatty acid as part of a glycolipid attached to the peptide backbone. Its activity was, in most respects, similar to that of other glycopeptides, such as vancomycin and teicoplanin. However, in addition to inhibiting gram-positive bacteria, A40926 was very active against Neisseria gonorrhoeae. A40926 was rapidly bactericidal for N. gonorrhoeae clinical isolates at concentrations equal to or slightly higher than the MIC. In mice, levels in serum were higher and more prolonged than those of an equivalent subcutaneous dose of teicoplanin. These properties suggest that A40926 may have potential in the therapy of gonorrhea.


PMID: 2964225

Other references

Wang, H.; Kouri, G.; Wollheim, C.B., 2005: ER stress and SREBP-1 activation are implicated in b-cell glucolipotoxicity. Journal of Cell Science 118(17): 05-15

Novosel, M., 1961: Diagnosis of "predisposition" to accidents with the aid of psychological tests. Vojnosanitetski Pregled 18: 445-449

Jeffries, P.R., 2016: Signs of Maturity ... Simulations Are Growing and Getting More Attention. Nursing Education Perspectives 36(6): 358-359

Gromova T.G.; Moroz A.F., 1971: Effect of r factor on cell sensitivity of escherichia coli to uv and gamma radiation. Antibiotiki (Moscow) 16(11): 995-998

Ghishan, F.K.; Sobo, G., 1983: Intestinal maturation: in vivo zinc transport. Net absorption and the lumen to mucosa flux of Zn was investigated with an in vivo single pass perfusion technique in the proximal and distal small intestine, and in the colon segments of suckling (2-wk-old), weanling (3-wk-old) and adolescent (6-...

Siegwarth, A.A.Wishon.; Koyanagi, C., 2012: The Affordable Care Act: improved options for North Carolinians with mental illnesses. The Affordable Care Act, the health reform law enacted in 2010, offers new options to improve the quality of and access to mental health care for North Carolinians. This commentary will discuss provisions of the law that have the potential to enha...

Elwood, P.C.; Shinton, N.K.; Wilson, C.I.; Sweetnam, P.; Frazer, A.C., 1971: Haemoglobin, vitamin B12 and folate levels in the elderly. Hb values, packed cell volume (PCV), vitamin B-12 in serum and folacin in plasma and red cells were estimated in a representative sample of 533 persons over 65 years old in a mining valley and a seaside town in South Wales. There were no significa...

Medvedeva E.A.; Timofeeva E.D., 1980: Methodology for rapid treatment of microsporosis of the hairy part of the head. From 1976-1978, 143 children aged from 1-15 yr were examined for infection of the head by Microsporum canis and M. ferrugineum. They were treated with a 5% griseofulvin solution in a 90% dimethyl sulfoxide [DMSO] solution by peroral introduction c...

Carmean, W.H., 1976: Soil conditions affect growth of hardwoods in shelterbelts. Large, medium and small planting stock of green ash (Fraxinus pennsylvanica), Russian olive (Elaeagnus angustifolia), and Siberian peashrub (Caragana arborescens) were planted in western Minnesota on three calcareous glacial soil types: sandy loam...

Lindsley, D.B., 1944: Electroencephalograph. The author describes the history of electroencephalography, the nature of the phenomenon, and the development of the methodology. Variations in EEG are related to personality, development, a number of psychological and physiological factors, and t...