+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Action of 2-hydroxy-4,6-dimethoxyacetophenone isolated from Sebastiania schottiana

, : Action of 2-hydroxy-4,6-dimethoxyacetophenone isolated from Sebastiania schottiana. Planta Medica 56(1): 31-35

The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed. Xanthoxyline (30 to 300 microM) inhibited contractions of the rat uterus, guinea-pig ileum, and urinary bladder induced by several agonists in a non-competitive, non-selective, concentration-related manner, with the IC50's ranging between 47 and 190 microM. Twitches evoked by electrical-stimulation of strips of guinea-pig longitudinal ileum, urinary bladder, dog ureter, and rat left atrium were also inhibited dose-dependently by cumulative additions of xanthoxyline (IC50's between 50 and 480 microM). Xanthoxyline was found to be a potent inhibitor of spontaneous contractions of the circular smooth muscle layer of the dog ureter, yielding an IC50 of 54 microM. Repeated washing of all preparations completely reversed the inhibitory effects of xanthoxyline. Therefore, it appears that xanthoxyline induces a direct and non-selective inhibition of contractions triggered by agonists or electrical stimulation of smooth and cardiac muscle preparations. The elucidation of the mechanism(s) by which xanthoxyline induced muscle relaxation requires further investigations.


PMID: 2356240

DOI: 10.1055/s-2006-960878

Other references

Iwamoto, E.T.; Way, E.L., 1977: Circling behavior and stereotypy induced by intra nigral opiate micro injections. Stereotaxic microinjection of morphine, .beta.-endorphin, 1-methadone, levorphanol, 1-pentazocine and nalorphine unilaterally into the substantia nigra of naive, nonlesioned rats resulted in continuous circling behavior contralateral to the inject...

Dietis, N.; McDonald, J.; Molinari, S.; Calo, G.; Guerrini, R.; Rowbotham, D.J.; Lambert, D.G., 2012: Pharmacological characterization of the bifunctional opioid ligand H-Dmt-Tic-Gly-NH-Bzl (UFP-505). While producing good-quality analgesia, µ-opioid (MOP) receptor activation produces a number of side-effects including tolerance. Simultaneous blockade of -opioid (DOP) receptors has been shown to reduce tolerance to morphine. Here, we chara...

Barghout A.A.; Abdel Aziz A.S., 1986: A comparative study of body weight and growth rate of turkish and barki lambs during the suckling period. Body weight and daily gain of 27 Turkish and 30 Barki lambs during the suckling period (10 wks) were studied. Birth weight (BW, daily weight gain (DG) and weaning weight (WW) of Turkish lambs averaged 3.64 kg, 131 g, and 12.68 kg, resp. The corres...

Herlihy, M.; O.K.effe, W.F., 1987: Evaluation and model of temperature and rainfall effects on response to N sources applied to grassland in spring. Direct and residual effects of urea and calcium ammonium nitrate (CAN) on dry matter (DM) response were measured at a total of 12 application times in early spring over three years. The variation in the direct effect was described by models that i...

Slavinsky V.V. (Slavinskiy V.V), 2000: Convective origin of the deep mantle roots of continents; evidence from variations in asthenospheric heat flow with the thickness of the continental lithosphere. International Geological Congress, Abstracts = Congres Geologique International, Resumes: ages ; unpaginated. 2000.

Kamburg, R.A.; Ibragimov, O.B.; Kondrat'eva, M.B.; Valeeva, I.Kh.; Shamsutdinov, N.Sh., 1993: The comparative characteristics of the antiatherogenic effect of xymedon and parmidine. We've studied xymedon (30 mg/kg, 12 m) and parmidin (pyridinolcarbamate 30 mg/kg, 12 m.) effects on the development of experimental cholesterol atherosclerosis on rabbits. It was demonstrated that after the use of xymedon aorta damage reduces...

Marteil, L., 1956: Acclimatation du clam Venus mercenaria L en Bretagne. Revues des Travaux Inst Peches Marit, 20: 157-160

Allen, H.W., 1969: Three species of Mexican Krombeinia having an elongated tegula with an extended apical angle. (Hymenoptera: Tiphiidae). Proceedings of the Entomological Society of Washington, 71: 99-102

Davis, K.H.; Hawks, R.L.; Blanke, R.V., 1988: Assessment of laboratory quality in urine drug testing. A proficiency testing pilot study. As part of a program to develop accreditation guidelines for urine drug testing laboratories, a pilot study for proficiency testing was conducted. Fifty civilian, commercial laboratories were included on a voluntary basis. Drug-free urine specimen...

Fresen, O., 1952: Die Histomorphologie monozytarer Leukosen. Monocytic leukosis is a leukemic variety of the physiological reticular-histiocytic formation of monocytes and represents a one-sided differentiated reticulosis. Aleukemic reticulosis cannot be interpreted as aleukemic monocytosis, because, beside...