geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Activation of cellular immunity in mice under normal conditions and in tumor growth during treatment with glucosaminyl muramyl dipeptide


, : Activation of cellular immunity in mice under normal conditions and in tumor growth during treatment with glucosaminyl muramyl dipeptide. Voprosy Meditsinskoi Khimii 36(1): 58-60

In vitro stimulation of mice spleen cells by means of glucosaminyl muramyl dipeptide (GMDP) was accompanied by development of tumor necrosis factor and of interleukin-I. The factor was detected in blood serum only after administration of GMDP simultaneously with lipopolysaccharide. GMDP activated peritoneal macrophages; the phenomenon was evaluated by means of the macrophages ability to kill tumoral cells P815 as well as by interleukin-I production after additional stimulation with lipopolysaccharide. At the same time, an increase in proliferating activity of spleen and bone marrow cells was observed. An increase of middle lifetime and recovery of 24% mice of C57BL/6 strain with leukosis EL-4 were observed after complex treatment of the animals with GMDP, lipopolysaccharide, cyclophosphane and indomethacin.

US$29.90

PMID: 2343578


Other references

Hindmarsh, T.; Greitz, T., 1975: Computer cisternography in the diagnosis of communicating hydrocephalus. Further experiences with computer tomography of the intracranial CSF circulation (computer cisternography) using a water-soluble contrast medium are reported. The results of an investigation of 10 patients with hydrocephalus are reported and compa...

Orsini, A.; Molfetta, S.; Pagani, C., 2001: The importance of anatomical variants of the sapheno-femoral junction in lower-limb varicose vein surgery. In the surgical strategy of lower limb varicose veins, the fundamental objective is to prevent relapses. For this purpose, after having examined the international literature on the most frequent relapse causes, the authors emphasize that erroneous...

Li, F-Mei.; Liu, L.; Pang, L-Nan.; Shen, M.; Lu, H-Wen.; Zhang, X-Hong.; Chu, X.; Song, Z-Ju., 2017: Association of 4p14 and 6q27 variation with Graves disease: a case-control study and a meta-analysis of available evidence. The etiology of the Graves' disease (GD) is largely unknown. However, genetic factors are believed to play a major role. A recent genome-wide association study in a Han Chinese sample collection revealed two new Graves' disease (GD) risk...

Khan M.N.; Hayat C.S.; Chaudhry A.H.; Iqbal Z.; Hayat B., 1989: Prevalence of gastro intestinal helminths in sheep and goats at faisalabad pakistan abattoir. Five hundred guts, comprising 250 each from sheep and goats, were examined for parasites. The prevalence of helminths was 58.4 and 54.4 per cent in sheep and goats, respectively. The relative prevalence of trematodes, cestodes and nematodes was 20...

Luca C., 1979: Electro physiological properties of right heart and atrio ventricular conducting system in patients with alcoholic cardio myopathy. In 20 men with alcoholic cardiomyopathy, right atrial and right ventricular monophasic action potential, relative repolarization rate of phase 3 and effective refractory period were studied, as well as atrioventricular conduction properties. The d...

Tonon, S.A.; Picconi, M.A.; Zinovich, J.B.; Nardari, W.; Mampaey, M.; Galuppo, J.A.; Bos, P.D.; Badano, I.; Di-Lello, F.; Basiletti, J.; Gonzalez, J.V.; Alonio, L.V.; Teyssie, A.R., 2003: Prevalencia de la infeccion cervical por virus papiloma humano (HPV) en poblacion caucasica y guarani, residente en la provincia de Misiones, Argentina. A genital infection with human papillomavirus (HPV) of a high risk type is necessary for the development of cervical carcinoma. HPV viral distribution among diverse world populations is not homogeneous, viral reservoirs having been detected in par...

Drolc, Z.; Eyre, R., 1975: An aid to brain imaging. British Journal of Radiology 48(565): 48-49

Coenen, T.M.M.; Bertens, A.M.C.; Hoog, S.C.M. de; Verspeek Rip, C.M., 2000: Safety evaluation of a lactase enzyme preparation derived from Kluyveromyces lactis. Neutralact(R), the DSM brand name of a lactase enzyme preparation, obtained from a homologous rDNA strain of Kluyveromyces lactis, was subjected to a series of toxicological tests to document the safety for use as a processing aid in the dairy ind...

Pegram, R.G.; Walker, J.B.; Clifford, C.M.; Keirans, J.E., 1987: Comparison of populations of the Rhipicephalus simus group: R. simus, R. praetextatus, and R. muhsamae (Acari: Ixodidae). Integrated biological, ecological, and morphological studies were carried out on Rhipicephalus simus Koch group ticks from Africa and Arabia. Crossbreeding studies were undertaken using three geographically isolated populations: two strains initia...

Adebusuyi, A.A.; Foght, J.M., 2013: The EmhABC efflux pump in Pseudomonas fluorescens LP6a is involved in naphthalene tolerance but not efflux. The EmhABC efflux pump in <i>Pseudomonas fluorescens</i> LP6a effluxes polycyclic aromatic hydrocarbons (PAHs) such as phenanthrene and anthracene but not naphthalene. We previously showed that the presence of EmhABC decreased the effi...