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Age-related differences in phosphonoformate-induced bone toxicity in cats


, : Age-related differences in phosphonoformate-induced bone toxicity in cats. Calcified Tissue International 48(5): 353-361

Phosphonoformate (PFA), a monophosphonate pyrophosphate analog, caused plasma biochemical and bone histomorphologic abnormalities in cats given 1,000 mg/kg/day as a continuous intravenous infusion for 14 days. Plasma biochemical alterations observed in young cats (10 weeks old) treated with PFA included increased calcium and decreased phosphorus, alkaline phosphatase, and calcitriol. Young cats treated with PFA developed rickets-like lesions characterized by widened growth plates, increased osteoid, and failure of mineralization. In addition, area of mineralized trabecular bone was decreased. Osteoclast size was increased whereas osteoclast perimeter and number were unaffected in young PFA-treated cats. Plasma alkaline phosphatase was decreased in adult cats (greater than or equal to 1 year old) treated with PFA but changes in calcium, calcitriol, and immunoreactive parathyroid hormone were highly variable and not significantly different. Adult cats treated with PFA exhibited osteomalacia characterized by increased osteoid area, perimeter, and width with failure of mineralization. In addition, static resorption indices were increased in PFA-treated adult cats but area of mineralized trabecular bone was not decreased. The monophosphonate PFA inhibited bone mineralization in young and adult cats similar to bisphosphonate treatment in other species. Because PFA is currently in phase I trials for use in AIDS, results of this study suggest a need to evaluate patients treated with PFA for metabolic bone disease.

US$29.90

PMID: 1829019


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Sueyoshi, R.; Okawada, M.; Fujimura, J.; Saito, M.; Koga, H.; Lane, G.J.; Yamataka, A., 2015: Successful complete resection of Ewing sarcoma arising from the bladder in a 10-year-old boy after chemotherapy. Ewing sarcoma (ES) of the bladder is extremely rare. Here we report the successful treatment of the youngest case of ES arising from bladder encountered to date and a literature review. A 10-year-old boy who presented with polyuria and lower abdom...

Rao, G.S.da; Somayajulu, K.R., 2006: Fishery and stock assessment of the blood clam Anadara granosa (Linnaeus) from Kakinada Bay. Landing and effort data of Anadara granosa (Linnaeus) from Kakinada Bay were collected for the years 1988 to 1991. The landings during 1988 were 802 tonnes compared to 1600 tonnes in 1991. The effort in 1988 was estimated at 32,458 man-days, whic...

D.C.ck, E.; Hermans, C.; D.R.eymaecker, J.; D.C.unynck, K.; D.M.eyer, B.; Vandeputte, N.; Vandenbulcke, A.; Deckmyn, H.; Rottensteiner, H.; D.M.eyer, M.; D.M.yer, S.F.; Vanhoorelbeke, K., 2015: The novel ADAMTS13-p.D187H mutation impairs ADAMTS13 activity and secretion and contributes to thrombotic thrombocytopenic purpura in mice. Congenital thrombotic thrombocytopenic purpura (TTP) is characterized by mutations in the ADAMTS13 gene, which either impair protein secretion or influence ADAMTS13 (A Disintegrin-like And Metalloprotease domain with ThromboSpondin type-1 motif, m...

Bhadania, A.G.; Patel, S.J.; Shah, U.S., 1986: Use of roller dryer for manufacture of khoa. Khoa was prepared from buffaloes' milk (with a 5% fat content) either by the conventional method or by a roller-drier technique which involved concentrating the milk to 50-55% TS in a double-jacketed steam kettle with continuous stirring, and...

Lee, J-Han.; Kim, Y.; Choi, J-Woo.; Kim, Y-Sik., 2014: Prevalence and prognostic significance of Epstein-Barr virus infection in classical Hodgkin's lymphoma: a meta-analysis. The prevalence and prognostic significance of Epstein-Barr virus (EBV) infection in classical Hodgkin's lymphomas (cHLs) remain elusive. To examine the epidemiological and prognostic differences between EBV-positive and -negative cHLs, we con...

Wahlstroem Rutger; Gruenthal G., 2000: Probabilistic seismic hazard assessment (horizontal PGA) for Sweden, Finland and Denmark using different logic tree approaches. Recent methods of probabilistic seismic hazard assessment allow multiple values to be assigned to the various input parameters. Each combination of values (branch) gives an output hazard estimate. From all combinations (logic tree), percentile haz...

Anonymous, 1969: A child in hospital. Lancet 1(7591): 413-413

Fleischmajer, R.; Perlish, J.S., 1980: Capillary alterations in scleroderma. Electron microscopy of capillaries was performed in scleroderma skin. The main alterations were (1) gaps, vacuolization and eventual destruction of endothelial cells, (2) reduplication of the basal lamina, (3) perivascular cellular infiltrates con...

Durko, M., 2001: Studies on pathologic changes localized in the middle ear, their influence on hearing impairment and choice of surgical treatment. Otolaryngologia Polska 54(5): 623-625

Rozenberg G.S., 1981: Status and problems of implantation modeling of phytocenotic systems. Uspekhi Sovremennoi Biologii 91(2): 293-307