+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Amplitude-modulated tone encoding behavior of cochlear nucleus neurons: modeling study

, : Amplitude-modulated tone encoding behavior of cochlear nucleus neurons: modeling study. Hearing Research 58(2): 153-165

A recent study of amplitude-modulated (AM) tone encoding behavior of dorsal and posteroventral cochlear nucleus (DCN and PVCN) neurons by Kim et al. [Hear. Res. 45, 95-113, 1990] observed that certain neurons (e.g., pause/build type-III neurons and chop-S neurons) tended to exhibit band-pass modulation transfer functions (MTFs) and intrinsic oscillations (IOs) whereas certain other neurons (e.g., chop-T neurons) tended to exhibit low-pass MTFs and no IOs. The goal of the present study was to develop models of these response characteristics in an attempt to understand the underlying neuronal mechanisms. We hypothesized that chopper neurons corresponded to stellate cells and pause/build neurons corresponded to fusiform cells. We also hypothesized that, with right input combination, appropriate models of a single stellate and fusiform cell could account for band-pass and low-pass MTFs as well as the associated IOs. The neuron models developed by Arle and Kim [Biol. Cybern. 64, 273-283, 1991] for the stellate and fusiform cells were used in this study. The models are modified versions of MacGregor type neuron model incorporating cell-specific nonlinear voltage-dependent conductances. The AM tone excitation via the auditory nerve fibers was represented by a current at the soma of the neuron model, which consisted of dc, ac and a zero-mean Gaussian noise. The dc, ac and noise represent a high-frequency carrier beyond the neuron's phase-locking limit, an envelope, and randomness of the system, respectively. With systematic variation of dc, ac and noise amplitudes, we observed the following: the band-pass MTF behaviors of pause/build and chop-S neurons were reproduced by the fusiform cell model and the stellate cell model with a strong dc/noise ratio, respectively. The low-pass MTF behavior of a chop-T neuron was reproduced by the stellate cell model with a weak dc/noise ratio. It was observed that the stellate cell model was more susceptible to the noise, in the sense that an increase in noise tended to abolish the IO and change the MTF of the model from band-pass to low-pass more readily in the stellate cell model than in the fusiform cell model. Kim et al. (1990) observed a close correlation between the IO frequency and the best envelope frequency (BEF). In the models, a similar correlation was observed between the two measures for both the stellate and fusiform cell models.(ABSTRACT TRUNCATED AT 400 WORDS)


PMID: 1568937

Other references

Vinuela A.; Fernandez Rojo F.; Gonzalez Nunez A., 1984: Hem angio endothelioma of bone a case with massive tissular necrosis. Pathology Research & Practice 178(3): 297-300

Saenz, J.; Macaya-Lizano, A., 1981: Phyllachora stahlii (Chardon) parasitic on Ficus goldmanii: a new record for Costa Rica. Revista de biologia tropical 29(2): 295-298

Gurvich, E.B.; Novokhatskaia, E.A.; Rubtsova, N.B., 1996: Mortality of people residing near electric power supply line with voltage of 500 kV. The epidemiologic study covered causes and levels of mortality in the settlement situated near electric power supply line (voltage is 500 kV). The work used retrospective cohort method adjusted for evaluation of mortality in general population. Th...

Cornelissen J.J.; Makel I.; Benaissa Trouw B.J.; Algra A.; Schellekens J.F.P.; Kraaijeveld C.A.; Verhoef J., 1992: Protection against experimental endotoxemia comparison of anti lipid a murine monoclonal antibodies with the human monoclonal antibody ha 1a. Clinical Research 40(2): 287A

Mcshan, W.H.; Kramer, S.; Schlegel, V., 1954: Oxidative enzymes in the thoracic muscles of the woodroach Leucopheae maderae. The thoracic muscle of the wood-roach, L. maderae. was shown to contain high concns. of succinoxidase and cytochrome oxidase and a low concn. of fatty acid oxidase as compared to rat liver. The conditions required for optimum activity of the succi...

M.C.rdona; R.J.shi*, 2007: The challenge of balancing methodological research rigour and practical needs in low-income settings: what we are doing and what we need to do better. Critical Public Health 17(1): 81-89

Chan, E.K.; Woods, R.; Virani, S.; Speers, C.; Wai, E.S.; Nichol, A.; McBride, M.L.; Tyldesley, S., 2015: Long-term mortality from cardiac causes after adjuvant hypofractionated vs. conventional radiotherapy for localized left-sided breast cancer. Ongoing concern remains regarding cardiac injury with hypofractionated whole breast/chest-wall radiotherapy (HF-WBI) compared to conventional radiotherapy (CF-WBI) in left-sided breast cancer patients. The purpose was to determine if cardiac morta...

Bogdanov, G.A., 1966: On some principles of the linear growth of the small herring in Kandalak bay. Unknown

Dziewulska, D.; Gogol, A.; Gogol, P.; Rafalowska, J., 2014: Enlargement of the Nissl substance as a manifestation of early damage to spinal cord motoneurons in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motoneurons. Recent studies indicate that in ALS, degeneration of motoneuron body is late in comparison to degeneration of axons. The morphological consequence of the axonal dam...

Domagk, G., 1957: Experimental basis for chemotherapy with sulfonamides. Antibiotica et Chemotherapia. Fortschritte. Advances. Progres 4: 1-45