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An interpretation of retinopathy of prematurity in terms of spindle cells: relationship to vitamin E prophylaxis and cryotherapy

, : An interpretation of retinopathy of prematurity in terms of spindle cells: relationship to vitamin E prophylaxis and cryotherapy. Graefe's Archive for Clinical and Experimental Ophthalmology 224(3): 205-214

Spindle cells in the hyperoxygenated, avascular, vanguard retina are proposed to be the peripheral inducers of the neovascularization associated with retinopathy of prematurity (ROP). The induction of ROP is conceptualized in terms of three basic events. First, activation of spindle cells results initially in the increase in gap junctions between adjacent spindle cells, secondarily in the increase in cytoplasmic volume of rough endoplasmic reticulum, and ultimately in the synthesis and secretion of angiogenic factors Second, maturation of spindle cells is associated with a decrease in gap junctions, a diminished cytoplasmic volume of rough endoplasmic reticulum, and a cessation of synthesis and secretion of angiogenic factors. Third, myofibroblasts invade the vitreous concomitantly with spindle cell maturation and provide the tractional force that can produce retinal separation. The extent of interstitial retinol binding protein within the subretinal space explains the gestational-age-dependent efficacy of vitamin E in suppressing the development of severe ROP. The kinetics of both spindle cell activation/maturation and myofibroblast invasion predict the efficacy of appropriately timed and placed transretinal cryotherapy.


PMID: 3519367

Other references

Weber L.J.mes; Walker Kenneth R., 1987: Discrimination of autocyclic versus eustatic cycle models through correlation of sedimentary cycles. Program

Murase, T.; Ecelbarger, C.A.; Lee, A.J.; Nielsen, S.; Knepper, M.A.; Verbalis, J.G., 1997: Downregulation of kidney aquaporin-2 expression during renal escape from antidiuresis occurs independently of changes in plasma or interstitial osmolality. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 22A, Sept

Mahendroo, M.S.; Means, G.D.; Mendelson, C.R.; Simpson, E.R., 1991: Tissue-specific expression of human P-450AROM. The promoter responsible for expression in adipose tissue is different from that utilized in placenta. The biosynthesis of estrogens from androgens is catalyzed by a enzyme of the endoplasmic reticulum termed aromatase cytochrome P-450 (P-450AROM). The gene encoding P-450AROM was isolated in our laboratory utilizing a full-length P-450AROM cDNA and...

Mel'nikov, V.K.; Kuz'min, G.A., 1970: The dynamics of resistance to low frequency electrical stimulation in 1-year-old apple shoots and its use for comparative evaluation of cold-hardiness. A simplified method and equipment are described for determining the electrical resistance of tissues. The data obtained can be used for analysing the physiological state of the plants. The lowest resistance in the 4 cvs studied was noted during ac...

Yoon, S-Y.; Patel, D.; Dougherty, P.M., 2013: Minocycline blocks lipopolysaccharide induced hyperalgesia by suppression of microglia but not astrocytes. Systemic injection of lipopolysaccharide (LPS) induces a robust immune response as well as thermal and mechanical hyperalgesia. Spinal and peripheral glial cells have been implicated as important mediators in this hyperalgesia but the specific con...

Price, J.E.; Owen Schaub, L.; Van Golen, K.L., 1996: Mutant p53 protects metastatic melanoma cells from Fas/CD95-mediated apoptosis. Clinical & Experimental Metastasis 14(SUPPL 1): 31

Lasnitzki, A., 1930: Tumorstoffwechsel und Tumorentstehung Theoretische Betrachtungen uber ihren Zusammenhang. The author thoroughly reviews the subject of the glycolytic metabolism of tumors, with reference to the relations of this to tumor inception. He first establishes the fact that aerobic glycolysis is a general feature of tumor cells. Next he discus...

Roth, R.; Fogel, S., 1971: A system selective for yeast mutants deficient in meiotic recombination. Molecular and General Genetics 112(4): 295-305

Chigbu, P.; Sibley, T.H., 1994: Diet and growth of longfin smelt and juvenile sockeye salmon in Lake Washington. Internationale Vereinigung fuer Theoretische und Angewandte Limnologie Verhandlungen, 254: 2086-2091

Somers G.; Devis G.; Malaisse W.J., 1976: Is calcium per se able to stimulate insulin release. European Journal of Clinical Investigation 6(4): 329