geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Antiepileptic drugs, cognitive function, and behavior in children


, : Antiepileptic drugs, cognitive function, and behavior in children. Cleveland Clinic Journal of Medicine 56 Suppl Pt 1: S140-6; Discussion S147-9

In conclusion, it should be repeated that behavioral and cognitive functions in children with epilepsy, as in adults, represent the outcome of multifactorial processes. However, interest has been growing in the role of anticonvulsant drugs as an important variable. Studies in adults have clearly shown the impact of these drugs on both cognitive function and behavior, and the beneficial effects of achieving monotherapy, especially with carbamazepine, have been noted. Extrapolation of these results to children would seem reasonable, and there is some evidence in the literature to support this conclusion. Data in children, however, are complicated by several confounding factors. These include the status of the child under investigation; for example, children with a pre-existing behavior disorder appear to be more susceptible to developing grossly disturbed behavior with medications such as phenobarbital, as opposed to those who at pretreatment assessment do not display abnormalities. Mentally retarded children may be another group specifically susceptible to developing problems with medications. The effect of the anticonvulsant drug on seizure frequency is a complicating variable in interpretation of many investigations: in some patients improvement of seizures leads to improved behavior, while in others the opposite occurs. In some children, behavior exacerbations appear to be provoked by the sudden cessation of seizures, which may occur, for example, in forced normalization associated with barbiturates or benzodiazepines. Serum level monitoring is often not possible in childhood studies because of ethical considerations, and interpreting pharmacokinetic interactions from mere knowledge of orally prescribed agents is hazardous.

US$29.90

PMID: 2655989


Other references

Carrión Valero, F.; Edo Esteban, M.J.; Pascual Izuel, J.M., 1998: Tobacco addiction in respiratory outpatients. Anales de Medicina Interna 15(2): 116-117

Scott, P.M.; Miles, W.F.; Toft, P.; Dube, J.G., 1972: Occurrence of patulin in apple juice. Patulin was found, at 1 ppm, in bottled 'sweet apple cider' but not in 11 samples of commercial apple juice. The toxin was first detected by thin-layer chromatography. The spot was eluted and more purified material was obtained for use i...

Ortona L.; Laghi V.; Tamburrini E.; Cauda R., 1986: Immune function and infections in drug abusers. Giornale di Malattie Infettive e Parassitarie 38(4): 356-366

Ault, A., 1999: The National Institutes of Health flexes its muscle--but why now?. The NIH's Office of Protection from Research Risks has come to be feared by researchers following its move to shut down Duke University's research programs for failing to comply with regulations. Now, researchers fear that the NIH will m...

Wells, B.R., 1980: Zinc nutrition of rice growing on Arkansas soils. Zn nutrition trials with dry-sown rice were conducted throughout Arkansas in 1973-7. Zn uptake varied between cv. during seedling establishment, being greatest in cv. Bonnet 73 and Nato. Grain yields were increased by flooding but Zn uptake was re...

Rapinesi, C.; Del Casale, A.; Serata, D.; Caccia, F.; D.P.etro, S.; Scatena, P.; Carbonetti, P.; Fensore, C.; Angeletti, G.; Tatarelli, R.; Kotzalidis, G.D.; Girardi, P., 2014: Electroconvulsive therapy in a man with comorbid severe obesity, binge eating disorder, and bipolar disorder. A 41-year-old man with comorbid binge-eating disorder, severe obesity, and bipolar disorder since the age of 20 years, resistant to drug and psychotherapy combinations, worsened progressively. Relentless weight gain forced him to immobility and de...

Kaluza, Tadeusz., 1994: Small mammals of the Promno area near Poznan. Badania Fizjograficzne nad Polska Zachodnia Seria C Zoologia, 41: 51-60

Maesako J.; Kataoka K.; Shingenaka Y., 1985: Continuity of endoplasmic reticular system in heliozoan cells. Zoological Science (Tokyo) 2(6): 892

Shkola, A.I., 1968: Promising herbicides in soybean plantings in irrigated soil of south-eastern Kazakhstan. Prometryne at 2-2.5 kg and chloramben 4-5 kg/ ha pre-em. were the best treatments examined in soyabeans on a pale-chestnut silty loam soil during 1964-6; propazine at 1-2 kg/ha was also effective.

Nakamura, K.; Kimura, M.; Aviv, A., 1995: Role of cyclic nucleotides in store-mediated external Ca2+ entry in human platelets. This study explores the role of cyclic nucleotides (i.e. cyclic AMP and cyclic GMP) in store-regulated external Ca-2+ entry in human platelets. To stimulate store-regulated external Ca-2+ entry, thapsigargin was used to deplete Ca-2+ from the dens...